Another randomized, double-blind, placebo-controlled, single-center clinical trial conducted in the United States showed that 39 % of participants showed significant improvement vs. 3 % of placebo.

In 2009 the results of a randomized double-blind placebo-controlled crossover trial on the use of magnetic wrist straps ( a leather strap with a magnetic insert ) for osteoarthritis were published, addressing a gap in the earlier systematic review.

Two double-blind placebo-controlled studies confirmed the efficacy of sertraline for severe chronic PTSD in civilians, with the mean duration of the illness more than ten years.

St John's wort was found to be less effective than placebo, in a randomized, double-blind, placebo-controlled trial, for the treatment of irritable bowel syndrome.

A double-blind placebo-controlled study on arthroscopic surgery for osteoarthritis of the knee was published in the New England Journal of Medicine in 2002.

Currently, some Phase 2 and most Phase 3 drug trials are designed as randomized, double-blind, and placebo-controlled.

However, recent data arising from a large, multicenter, double-blind, placebo-controlled trial indicate EPA administration alone is not successful in the treatment of weight loss in patients with advanced gastrointestinal or lung cancer.

To date there have been no published results of any large, double-blind, placebo-controlled studies comparing the efficacy and safety of these or any other medications for absence seizures.

A recent meta-analysis of anti-obesity medications pooled the results of three double-blind, placebo-controlled trials of bupropion.

Only double-blind randomized placebo-controlled clinical trials can confirm a hypothesis about the effectiveness of a treatment independently of expectations.

* In a multicenter, randomized, double-blind, placebo-controlled trial involving 78 participants with osteoporotic vertebral compression fractures, patients who underwent vertebroplasty had improvements in pain and disability measures that were similar to those in patients who underwent a sham procedure.

In the randomized ‚ double-blind ‚ placebo-controlled trial of Neupogen therapy following combination chemotherapy in patients ( n = 207 ) with small cell lung cancer ‚ the chart displays adverse events were reported during blinded cycles of study medication ( placebo or Neupogen at 4 to 8 mcg / kg / day ).

In a randomized, double-blind, placebo-controlled crossover trial, 50 adults with coronary disease or ≥ 1 cardiac risk factor received muscadine grape seed supplementation ( 1300 mg daily ) and placebo for 4 weeks.

A preliminary 12-week, randomized, double-blind, placebo-controlled trial was conducted at Duke University Medical Center which studied the effectiveness of atomoxetine on adult obese women.

* Food challenges, especially double-blind placebo-controlled food challenges ( DBPCFC ), are the gold standard for diagnosis of food allergies, including most non-IgE mediated reactions.

* Isoflavones — may be related to cognitive function A double-blind, placebo-controlled study showed improvement in spatial working memory after administration of an isoflavone combination containing daidzein, genistein & glycitin.

In a randomized, double-blind, placebo-controlled study of older, non-demented men & women, soy isoflavone supplementation improved performance on 6 of 11 cognitive tests, including visual-spatial memory and construction, verbal fluency and speeded dexterity ; unexpectedly, the placebo group performed better on 2 tests of executive function.

A meta-analysis of 41 double-blind, placebo-controlled studies concluded that nicotine or smoking had significant positive effects on fine motor, alerting attention-accuracy and response time ( RT ), orienting attention-RT, short-term episodic memory-accuracy, and working memory-RT.

In a randomized, double-blind, placebo-controlled study of 18 healthy volunteers, 600 mg of ' Melissa officinalis ' extract attenuated volunteers ' response to a laboratory-induced stress test 1 hour after administration ; 300 mg significantly improved speed of mathematical processing 1 hour after administration.

A double-blind, placebo-controlled trial in young healthy females showed an improvement in short-term memory performance 1 hour after administration of a 600 mg dose.

" A double-blind, placebo-controlled study in 20 young healthy volunteers showed a dose-dependent improvement in speed-of-attention following administration of 240 mg and 360 mg of Ginkgo extract, effects were measured 2. 5h after administration and persisted at least until 6h ; various other time-and dose-specific changes ( some positive, some negative ) in other areas were observed.

Also improved cognitive ability, in a double-blind, parallel-group, placebo-controlled trial.

Desmopressin ( 1-desamino-8-D-arginine vasopressin, DDAVP ) was given to 17 children with attention & learning disorders daily for 10 days in a placebo-controlled, randomized, double-blind study ; memory & learning were improved compared with placebo ; the same study failed to find similar benefits after administration of a single dose.

A two week regimen of piracetam was reported in 1976 to enhance verbal memory in healthy college students in a double-blind, placebo-controlled study.

* Inositol In a double-blind, controlled trial, myo-inositol ( 18 grams daily ) was superior to fluvoxamine for decreasing the number of panic attacks and had fewer side-effects.

Also, it is used topically as a 4 % or 5 % gel or cream-as effective as topical 1 % clindamycin ( 8-week double-blind trial ) performed at the New York University College of Medicine.

A year-long 300-participant double-blind, phase II trial has begun.

Later work that used these ChromaGen lenses with dyslexics in a randomised, double-blind, placebo controlled trial showed highly significant improvements in reading ability over reading without the lenses This system has been granted FDA approval in the USA.

In a double-blind discontinuation trial, abruptly stopping sertraline after one year of successful treatment resulted in relapse of the disorder in 33 % of the patients vs. 13 % of those who continued taking sertraline over the following 28 weeks.

As of 2011 there has not been any double-blind, randomized prospective clinical trial of mate drinking with respect to chronic disease.

The drug is then administered in a double-blind controlled trial, which allows researchers to determine the effect of the drug and the dose-response curve.

In a randomized double-blind placebo controlled trial by Sagheb, et al., vitamins C, E and their combination were found to be effective in the treatment of RLS in hemodialysis patients compared to the placebo.

In the early 1950s, a double-blind clinical trial at the University of Chicago assessed pregnancy outcomes in women who were assigned to either receive or not receive DES.

An improvement in the lean body mass and improved quality of life were also observed in a randomized, double-blind trial using a protein and energy-dense, omega-3 fatty acids-enriched oral supplement, provided its consumption was equal or superior to 2. 2 g of eicosapentaenoic acid per day.

; Vazirian, M .; Shayeganpour, A .; Rashidi, H. & Khani, M. ( 2001 ): Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam.

( 2010 ) who performed a double-blind, randomized, controlled clinical trial, to compare the efficacy, tolerability, and neuropsychological effects of ethosuximide, valproic acid, and lamotrigine in children with newly diagnosed childhood absence epilepsy.

In 1984, researchers at the University of Rochester Medical Center reported that they had performed a double-blind, controlled clinical trial comparing phentermine alone, fenfluramine alone, a combination of phentermine and fenfluramine, and placebo, for weight loss in humans.

Obvious experimental difficulties ( particularly in constructing a double-blind clinical trial ) mean that this is a difficult hypothesis to reliably test to any requisite evidence-based standard.

A small ( 40 people ), 10-week, double-blind clinical trial was reported in the Journal of Clinical Psychiatry on the effectiveness of atomoxetine for treating binge eating disorder.

A double-blind inhalant challenge in 1991 concluded, " The conclusion of the study is that in these patients, chemical sensitivity clearly does exist ( pulse rate differences between positive responses and placebo-p. 001 )"

In one double-blind, placebo controlled, study conducted in the United Kingdom 48. 6 % of patients who used the nicotine patch, in conjunction with their standard treatment, showed complete resolution of symptoms.

In a double-blind study of remitted panic disorder patients, abrupt discontinuation of sertraline treatment resulted in insomnia and dizziness ( both 16 – 17 % vs. 4 % for continuing treatment ), although headache, depression and malaise did not increase significantly.

In another double-blind study of recovered panic disorder patients, the withdrawal syndrome was completely avoided when sertraline was gradually discontinued over three weeks, while patients stopping paroxetine treatment still suffered from it ..

During the 1970s and 1980s, his book and articles on the " Awakenings " patients were criticized or ignored by much of the medical establishment, on the grounds that his work was not based on the quantitative, double-blind study model.

A double-blind study, reported in 2004, found no clinically significant difference between these two types of patients with regard to the subjective or objective measures of disease severity.

In a double-blind study, patients who did not respond to an SSRI were switched to venlafaxine or citalopram.

Events are reported as exposure-adjusted since patients remained on double-blind Neupogen a median of 3 cycles versus 1 cycle for placebo.

Liposomal amphotericin B was effective as empirical therapy or as treatment for confirmed invasive fungal infections in several randomized, double-blind trials ( n = 73 − 1095 ) in adult and pediatric patients.

Effects of a procaine preparation ( Gerovital H3 ) in hospitalized geriatric patients: a double-blind study.

::" The overall results of this double-blind study strongly indicated that, among these hospitalized geriatric patients with organic symptoms, Gerovital H3 had no ameliorative effect on either psychologic or physiologic functioning.

Tea tree oil improves the symptoms but does not cure the underlying fungal infection, according to a double-blind study of 104 patients.

LOTS was a randomized, double-blind, placebo-controlled study that enrolled 90 patients at eight primary sites in the United States and Europe.

A 2004 meta-analysis, pooling data from three double-blind placebo-controlled studies, found the multiple herbal extract Iberogast to be significantly more effective than placebo ( p value =. 001 ) at treating patients with functional dyspepsia through the targeting of multiple dyspeptic pathologies.

In a published double-blind study as well as two published clinical studies, MS patients receiving Prokarin ™ demonstrated improvement in fatigue, hand dexterity, walking, balance, bladder function, cognition, and heat sensitivity.

In 2000, EDMS funded a double-blind study on 29 patients showing significant improvement in the group of patients receiving the Prokarin as compared to the placebo group.