Penicillinase was the first β-lactamase to be identified: It was first isolated by Abraham and Chain in 1940 from Gram-negative E. coli even before penicillin entered clinical use, but penicillinase production quickly spread to bacteria that previously did not produce it or produced it only rarely.

With the end of Roman civilization, Western Europe entered the Middle Ages with great difficulties that affected the continent's intellectual production.

The GÉANT project began in November 2000, entered full production operation in December 2001 ( fully replacing TEN-155 ).

Eventually, Kid Icarus was finished and entered production a mere three days before the release date.

In the 1940s Cyril Pullin developed the Powerwheel, a wheel with a rotating one-cylinder engine, clutch and drum brake inside the hub, but it never entered production.

Years before Robin Hood had even entered production, Disney had considered doing a project on Reynard the Fox.

However, by the time it entered production in May 1990, the two states had already agreed to reunification.

As the series entered into production, the budget required it be cut down to twenty-six episodes before work began on the final scripts and animation began.

* TVR Cerbera Speed Twelve ( never entered production )

This was developed side by side with an airframe, the Hawker P. 1127, which became subsequently the Kestrel and then entered production as the Hawker Siddeley Harrier, though the supersonic Hawker Siddeley P. 1154 was canceled in 1965.

Kawasaki presented also in 1972 its Kawasaki X99 RCE prototype ( US patent N 3848574 ), both Yamaha and Kawasaki claimed having solved all problems previously found in Wankel RCEs, but none entered the stage of production.

The 880 continued into 1965, the year a completely new full-size body was put into production, the Polara entered the medium price class and the Monaco was added as the top series.

The former entered production and service while the latter did not.

It entered production as the F-16 in January 1975 with an initial order of 650 and a total order of 1, 388.

The 2. 1-liter 402 entered production in 1935 and was produced until the end of 1941, despite France's occupation by the Nazis.

However, because they lacked capital and the planters continued to own the means of production ( tools, draft animals and land ), the freedmen were forced into producing cash crops ( mainly cotton ) for the land-owners and merchants, and they entered into a crop-lien system.

After lengthy negotiations, on February 1, 2005, the Nigerian and Sao Tomé governments entered into an exploration and production sharing agreement over the first of six different exploration blocs with a US dominated consortium led by ChevronTexaco with 51 % of the equity, ExxonMobil with 40 % and Dangote Energy Equity Resources, a small Nigerian and Norwegian company with the remaining 9 %.

Electroluminescent automotive instrument panel backlighting, with each gauge pointer also an individual light source, entered production on 1960 Chrysler and Imperial passenger cars, and was continued successfully on several Chrysler vehicles through 1967.

Sylvania Lighting Division in Salem and Danvers, MA, produced and marketed an EL night lamp ( right ), under the trade name Panelescent at roughly the same time that the Chrysler instrument panels entered production.

In May a new company, Sinclair Vehicles Ltd, was formed out of Sinclair Research and a development contract entered with Lotus to take the C5 design to production.

Her next picture was Jezebel ( 1938 ), and during production Davis entered a relationship with director William Wyler.

Although two designs, the Canadair CL-84 Dynavert and the LTV XC-142, were technical successes, neither entered production due to other issues.

Despite a rather disastrous production in Bergamo shortly after its initial run at La Fenice, the opera soon entered the repertory of Italian theatres.

Called the GAZ 11, this more upscale model entered production in 1942 and remained in limited wartime production until 1946.

This patient was a 65-year-old white male accountant who entered the New York Hospital for his fourth and terminal admission on June 26, 1959, because of disabling weakness and general debility.

The main treaty was opened for signature on December 1, 1959, and officially entered into force on June 23, 1961.

In 1959, Day entered her most successful phase as a film actress with a series of romantic comedies.

Center Wilt Chamberlain entered the league with the Warriors in 1959 and became a dominant individual star of the 1960s, setting new single game records in scoring ( 100 ) and rebounding ( 55 ).

After that, he entered business, first as an assistant to the director of a foundry in Ludwigshafen and, in 1959, as a manager for the Industrial Union for Chemistry in Ludwigshafen.

In 1959, Rhodes entered a joint venture with Leo Fender to manufacture the instruments under a company named Fender & Rhodes.

* Antarctic Treaty, signed 1959, entered into force 1961

* Antarctic Treaty, signed 1959, entered into force 1961

The Academy's permanent site had not yet been completed when the first class entered, so the 306 cadets from the Class of 1959 were sworn in at a temporary site at Lowry Air Force Base, in Denver on 11 July 1955.

In the 55th Parliament, only Peter Tapsell ( serving since 1959 ) has served longer, and Gerald Kaufman, Dennis Skinner and Michael Meacher all entered Parliament on the same day.

He entered the cabinet of Leslie Frost in 1958 as minister without portfolio, and was promoted to Minister of Education in 1959.

She entered Albany State College in 1959 ( since July 1996 Albany State University ) where she studied music.

In 1959, Ames entered the University of Chicago planning to study foreign cultures and history, but his " long-time passion " for drama resulted in failing grades, and he did not finish out his sophomore year.

This resulted in the criminal prosecution of Fringe Product, their label at the time, for distribution and possession with intent to distribute of obscene material — the first such prosecution since the offense entered the criminal code in 1959.

After driving across the state of Kansas on November 14, 1959, Hickock and Smith located the Clutter home and entered while the family slept.

The Antarctic Treaty and related agreements, collectively called the Antarctic Treaty System, A. T. S., was opened for signature on Dec. 1, 1959, and officially entered into force on June 23, 1961.

In beating Newcombe in four sets in the Wimbledon final, he captured the title at the All England Club for the fourth consecutive time that he had entered the tournament ( and reached the final for the sixth consecutive time as he had been runner-up in 1959 and 1960 ).

The film was entered into the 1959 Cannes Film Festival.

Some did not participate every year, others sent lesser teams ; in the 1959 edition held in Ecuador, Brazil entered a team from the state of Pernambuco.

After this he joined the painters Heimrad Prem, Helmut Sturm and Hans-Peter Zimmer in founding the group SPUR, which in 1959 entered the Situationist International.

After this he joined Heimrad Prem, Lothar Fischer and Hans-Peter Zimmer in founding Gruppe SPUR, which in 1959 entered the Situationist International.

Given the often complex badge-engineering that BMC undertook, it is common amongst enthusiasts to use the ADO number when referring to vehicles as a single design ( for example, saying ' The ADO15 entered production in 1959 '- this encompasses the fact that when launched, the ADO15 was marketed as both the Morris Mini Minor and the Austin Seven ).

Its construction began in 1955 and entered in service at the end of 1959, replacing the interim terminal and joining other portions of the then brand new airport.

In 1957, American Express also entered the field, and in 1959 was the first company to issue embossed plastic charge cards to ISO / IEC 7810 standards.