Its first apparition was a long, gloomy column of refugees riding in farm wagons, or pushing prams.

Its building was first proposed in 1791, when a group of citizens, mostly Newburyport men, petitioned the General Court for an act of incorporation.

Its first commercial use was as a seven-bit teleprinter code promoted by Bell data services.

The 1921 first published photo of The Ashes Urn: Its Origin and History | the Urn in the Illustrated London News.

Its first recording is an a cappella version from 1922 by the Sacred Harp Choir.

Its first Allied-appointed mayor, Franz Oppenhoff, was murdered by an SS commando unit.

Its first Arbor Day was celebrated on 2004-10-08.

Its happenings are set between the first and the second part of A. D. Police Files.

Its first product was Turbo Pascal in 1983, developed by Anders Hejlsberg ( who later developed. NET and C # for Microsoft ) and before Borland acquired the product sold in Scandinavia under the name of Compas Pascal.

Its first editor, William O. Eaton, just 22 years old, said " The Herald will be independent in politics and religion ; liberal, industrious, enterprising, critically concerned with literacy and dramatic matters, and diligent in its mission to report and analyze the news, local and global.

Its subject is the Return to Zion following the close of the Babylonian captivity, and it is divided into two parts, the first telling the story of the first return of exiles in the first year of Cyrus the Great ( 538 BC ) and the completion and dedication of the new Temple in Jerusalem in the sixth year of Darius ( 515 BC ), the second telling of the subsequent mission of Ezra to Jerusalem and his struggle to purify the Jews from the sin of marriage with non-Jews.

Its first modern incidence in biological warfare were when Scandinavian " freedom fighters " supplied by the German General Staff used anthrax with unknown results against the Imperial Russian Army in Finland in 1916.

Its expansion over the following two and a half centuries was largely a result of an expanding British colonial footprint and has resulted in the creation of several branch institutions, the first being the British Museum ( Natural History ) in South Kensington in 1887.

Its first publication was the Abridged Bliss Classification ( ABC ), intended for school libraries.

Its Cornish name, Goen Bren, is first recorded in the 12th century.

Its liturgy, from the first, combined the free use of Cranmer's language with an adherence to the principles of congregational participation and the centrality of the Eucharist, much in line with the Liturgical Movement.

Its first Lieutenant-Governor was Joseph Frederick Wallet DesBarres ( 1784 – 1787 ) and his successor was William Macarmick ( 1787 ).

Its combination of modern innovation ( such as mixed gender seating ) and traditional practice particularly appealed to first and second-generation Eastern European Jewish immigrants, who found Orthodoxy too restrictive, but Reform Judaism foreign.

Its functions were replaced by a fans forum which met for the first time in December 2008.

Its official definition, edited by Woodward, Wetherall and Gorman, was first published in 1970.

Its first chairman was Nikita Khrushchev, and he was succeeded in 1964 by Leonid Brezhnev.

Its first stock offering in 1613-1616 raised £ 418, 000, and its first offering in 1617-1622 raised £ 1. 6 million.

Its reliability and robustness were greatly appreciated by physicians, who drove a lot to see their patients, back when hard-surfaced roads were still rare.

Its binding affinity is high enough to theoretically break through a buprenorphine blockade to offer pain relief from acute trauma in patients who are taking high-dose buprenorphine.

Its product mix includes devices for the diagnosis and treatment of sleep apnea including CPAP and bi-level ( BiPAP ) machines, oxygen concentrators for patients requiring supplemental oxygen, infant apnea monitors for infants at risk of SIDS, asthma treatment solutions and hospital ventilators.

Its original purpose was to oversee the practice of sterilization as it pertained to inmates or patients of public-funded institutions that were judged to be ' mentally defective or feeble-minded ' by authorities.

Its frequency is higher in females, the elderly, and in patients who are hospitalized.

Its use is contraindicated in patients with hypersensitivity to glimepiride or other sulfonylureas, and during pregnancy.

Its main use is in patients with neuromuscular disorders who have some residual muscular function.

Its main complication of heart failure affects 21 – 32 % of patients.

Its progress differs among patients ; most cases are diagnosed before labor typically would begin.

Its aim is to support and promote the work of Addenbrooke's for the benefit of patients and staff, by raising extra funds to enhance services, facilities and research.

Its mission is to " discover, develop and deliver innovative medicines that help patients prevail over serious diseases.

Its members were aircrew patients in the hospital and the surgeons and anaesthetists who treated them.

Its products are used by healthcare providers to manage payments between patients, commercial payers ( such as insurance companies ) and government programmes.

Its design, in our opinion, was not to prevent the importation, sale, or carriage by mail of things which might intelligently be employed by conscientious and competent physicians for the purpose of saving life or promoting the well being of their patients.

Its aircraft are also capable of transporting litter and ambulatory patients using patient support pallets during aeromedical evacuations.

Its branch hospital, St. Ita's, Portrane, would have housed a similar number of patients.

Its mission is to " create a safe and enjoyable environment for the students, community members, and visitors who comprise our patrons, and to provide swift, efficient, and appropriate emergency medical care and rescue services to those who become our patients.

Its garden, where patients can relax, was opened by Elton John.

Its absolute bioavailability is reduced to about 16 % in patients with stable NYHA Class II-IV congestive heart failure, and the volume of distribution appears to be slightly smaller than that in normal subjects.

Its work under the leadership of Frances Wisebart Jacobs ranged from work with tuberculosis patients to the care and education of young children and was funded in part by direct assistance from the city itself.

Its flagship product, MedcomSoft Record 5. 0, is a comprehensive, integrated software suite that enables physicians to automate the majority of tasks required to manage practices and patients.

Its central aspect is the use of facetious but impressive-sounding acronyms and invented terminology to describe patients, co-workers or tricky situations.

Its main indication is for patients with pancretic exocrine insufficiency i. e., cystic fibrosis, chronic pancreatitis, pancreatectomy, pancreatic cancer and gastrotectomy.

Its main advantage was people would have no reason to use it for another other than a fire escape and patients could be slid down it in a fire on their bedding.