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Page "Cerebral cortex" ¶ 12
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# and Layer
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# Layer II, the External granular layer, contains small pyramidal neurons and numerous stellate neurons.
# Layer III, the External Pyramidal layer, contains predominantly small and medium-size pyramidal neurons, as well as non-pyramidal neurons with vertically oriented intracortical axons ; layers I through III are the main target of interhemispheric corticocortical afferents, and layer III is the principal source of corticocortical efferents.
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# Layer V, the Internal Pyramidal layer, contains large pyramidal neurons ( such as the Betz cells in the primary motor cortex ); it is the principal source of subcortical efferents, as such, there are large pyramidal cells which give rise to axons leaving the cortex and running down through the basal ganglia, the brain stem and the spinal cord.
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