MAOIs can also be used in the treatment of Parkinson's disease by targeting MAO-B in particular ( therefore affecting dopaminergic neurons ), as well as providing an alternative for migraine prophylaxis.

MAOIs appear to be particularly indicated for outpatients with " neurotic depression " complicated by panic disorder or hysteroid dysphoria, which involves repeated episodes of depressed mood in response to feeling rejected.

MAOIs act by inhibiting the activity of monoamine oxidase, thus preventing the breakdown of monoamine neurotransmitters and thereby increasing their availability.

In addition to reversibility, MAOIs differ by their selectivity of the MAO receptor.

As a result, the use by medical practitioners of these older MAOIs declined.

People taking MAOIs need to be careful, as psilocybin and psilocin are metabolized by the enzyme monoamine oxidase.

Because MPTP itself is not directly harmful, toxic effects of acute MPTP poisoning can be mitigated by the administration of monoamine oxidase inhibitors ( MAOIs ) such as selegiline.

MAOIs prevent the metabolism of MPTP to MPP + by inhibiting the action of MAO-B, minimizing toxicity and preventing neural death.

Harmine and harmaline are reversible MAOIs of the MAO-A isoform of the enzyme, and can stimulate the central nervous system by inhibiting the metabolism of monoamine compounds such as serotonin and norepinephrine.

It is important to note that unlike many synthetic pharmaceutical MAOIs such as phenelzine, harmine is reversible and selective meaning it does not have nearly as high a risk for the " cheese syndrome " caused by consuming tyramine-containing foods, which is a risk associated with monoamine oxidase A inhibitors, but not monoamine oxidase B inhibitors.

The potentiation of the pressor effect of tyramine by moclobemide is only one seventh to one tenth of that of irreversible MAOIs.

The inhibition of MAO-A by moclobemide is 10 times more potent than the irreversible MAOIs phenelzine and approximately equivalent to tranylcypromine and isocarboxazid.

A few newer MAOIs, a notable one being moclobemide, are reversible, meaning that they are able to detach from the enzyme to facilitate usual catabolism of the substrate.

Drugs including the monoamine oxidase inhibitors ( MAOIs ), tricyclic antidepressants ( TCAs ), tetracyclic antidepressants ( TeCAs ), selective serotonin reuptake inhibitors ( SSRIs ), and serotonin-norepinephrine reuptake inhibitors ( SNRIs ) are most commonly associated with the term.

Irreversible monoamine oxidase inhibitors ( MAOIs ) may be used if other antidepressant medications are ineffective.

A new generation of MAOIs has been introduced ; moclobemide ( Manerix ), known as a reversible inhibitor of monoamine oxidase A ( RIMA ), which is as effective as SSRIs and tricyclic antidepressants, in depressive disorders, acts in a more short-lived and selective manner and does not require a special diet.

The early MAOIs inhibited monoamine oxidase irreversibly.

They are not considered addictive and are somewhat preferable to the monoamine oxidase inhibitors ( MAOIs ).

* Many psychotropic medications, such as selective serotonin reuptake inhibitors ( SSRIs ), monoamine oxidase inhibitors ( MAOIs ), and tricyclic antidepressants, can cause hyperthermia.

Typically, a therapeutic response to MAOIs is believed to be associated with an inhibition of at least 80-85 % of monoamine oxidase activity.

It should be avoided in individuals who are also taking monoamine oxidase inhibitors ( MAOIs ).

They should never be taken within 14 days of any other antidepressant, especially with monoamine oxidase inhibitors ( MAOIs ), as combinations of SNRIs with MAOIs can cause hyperthermia, rigidity, myoclonus, autonomic instability with fluctuating vital signs, and mental status changes that include extreme agitation progressing to delirium and coma.

Several alkaloids that function as monoamine oxidase inhibitors ( MAOIs ) are found in the seeds of Peganum harmala ( also known as Harmal or Syrian Rue ), including harmine, harmaline, and harmalol, which are members of a group of substances with a similar chemical structure collectively known as harmala alkaloids.

The concomitant use of sibutramine and monoamine oxidase inhibitors ( MAOIs, such as selegiline ) is not indicated, as it may increase the risk of serotonin syndrome, a somewhat rare but serious adverse drug reaction.

By slowing the breakdown of neurotransmitters, monoamine oxidase inhibitors ( MAOIs ) can help to replenish the body's supply of these chemicals, and many MAOIs are used as antidepressants.

The drug should not be taken with any MAOIs ( monoamine oxidase inhibitors ), as unknown and potentially fatal effects may occur.

MAOIs or monoamine oxidase inhibitors increased the amount of serotonin in the pre-synaptic cell, but had many side-effects including intense migraines and high blood pressure.

In the 1950s the monoamine oxidase inhibitors ( MAOIs ) and tricyclic antidepressants were accidentally discovered to be effective in the treatment of depression.

Monoamine oxidase inhibitors ( MAOIs ) are very effective for anxiety, but due to drug dangers, are rarely prescribed.

Monoamine oxidase inhibitors ( MAOIs ) are a class of medications prescribed for the treatment of depression.

Monoamine oxidase inhibitors ( MAOIs ) are the oldest class of antidepressants.

Antidepressants including MAOIs have some dependence-producing effects, the most notable one being a withdrawal syndrome, which may be severe especially if MAOIs are discontinued abruptly or over-rapidly.

Irreversible MAOIs were the first antidepressants to be discovered, but they fell out of favour with the advent of the discovery of safer antidepressants ; these newer antidepressant drug classes have fewer adverse effects, especially the dangerous irreversible MAOI food interaction with tyramine, sometimes referred to as the ' cheese syndrome ', which leads to dangerous hypertension.

It contains harmine, harmaline, and tetrahydroharmine, all of which are both beta-carboline harmala alkaloids and MAOIs.

The MAOIs in B. caapi allow the primary psychoactive compound, DMT ( which is introduced from the other primary ingredient in ayahausca, the Psychotria viridis plant ), to be orally active.

In contrast to mirtazapine, the SSRIs, SNRIs, MAOIs, and some TCAs increase the general activity of the 5-HT < sub > 2A </ sub >, 5-HT < sub > 2C </ sub >, and 5-HT < sub > 3 </ sub > receptors leading to a host of negative changes and side effects, the most prominent of which include anorexia, insomnia, sexual dysfunction ( loss of libido and anorgasmia ), nausea, and diarrhea, among others.

* Tobacco – Contains nicotine, and harman & norharman which are MAOIs.

Medicines which may interact with phentermine, such ase dexfenfluramine, fenfluramine, furazolidone, or MAOIs ( e. g., phenelzine ) are contraindicated because of the risk of serious side effects, such as increasing headache, high blood pressure, slow heart rate, elevated temperature, or possibly fatal lung problems, may be increased.

Harmine has not been the subject of much clinical research in the treatment of depression, which could be due in part to its restricted legal status in many countries, as well as the existence of synthetic MAOIs with fewer side effects.

* Monoamine oxidase ( MAO ) inhibitors ( MAOIs ) including nonselective agents such as phenelzine ( Nardil ), tranylcypromine ( Parnate ), and isocarboxazid ( Marplan ), MAO < sub > A </ sub > selective agents like moclobemide ( Aurorix, Manerix ), and MAO < sub > B </ sub > selective agents such as selegiline ( Eldepryl, Zelapar, Emsam ), rasagiline ( Azilect ), and pargyline ( Eutonyl ), as well as the harmala alkaloids like harmine, harmaline, tetrahydroharmine, harmalol, harman, and norharman, which are found to varying degrees in Nicotiana tabacum ( Tobacco ; also cigarettes, cigars, chew, hookah, etc.

No significant rise in blood pressure occurs when moclobemide is combined with amines such as tyramine containing foods or pressor amine drugs, unlike the older non-selective irreversible MAOIs which cause a severe rise in blood pressure with such combination.