Many transcription factors use one or the other of two opposing mechanisms to regulate transcription:

Many of these GTFs don't actually bind DNA but are part of the large transcription preinitiation complex that interacts with RNA polymerase directly.

Many transcription factors in multicellular organisms are involved in development.

* phosphorylation – Many transcription factors such as STAT proteins must be phosphorylated before they can bind DNA.

Many transcription factors contain a structure known as a zinc finger, this is a structural module where a region of protein folds around a zinc ion.

Meric Casaubon's 1659 edition of part of these diaries ( Cotton Appendix MS. XLVI ), entitled A True & Faithful Relation of What Passed for Many Yeers between Dr. John Dee and Some Spirits contains notorious transcription errors which in some cases were transmitted through many subsequent republications of the Dee / Kelly material ; Casaubon's edition was intended to discredit Dee and Kelly by accusing them of dealing with the Christian Devil.

Many cellular processes ( DNA replication, transcription, translation, recombination, DNA repair, ribosome biogenesis ) involve the separation of nucleic acid strands.

Many eukaryotic non-coding RNAs are always polyadenylated at the end of transcription.

Many coiled coil type proteins are involved in important biological functions such as the regulation of gene expression e. g. transcription factors.

Many factors contributed to the growth of the European movement.

Many researchers are interested in the interaction between personal characteristics, the individual's behavior, and environmental factors including social context, and their impact on development ; others take a more narrowly-focused approach.

Many different factors influence the actual process of forgetting.

Many other factors involved resentments and aspirations given focus by the rise of Enlightenment ideals.

Many of its practitioners have added various further factors of production ( see below ).

Many other factors may play a role in the pathogenesis of the disease such as goitrogens ( isoflavones such as genistein, daidzein, and quercertin ) and iodine and selenium content in the diet.

Many hypnotic drugs are habit-forming and, due to a large number of factors known to disturb the human sleep pattern, a physician may instead recommend alternative sleeping patterns, sleep hygiene, and exercise, before prescribing medication for sleep.

Many factors can change insulin requirements and require an adjustment to the basal rate:

Many factors favoured its development as a language of its own.

Many other risk factors, some modifiable and others non modifiable such as genetic may be involved in osteoporosis.

Many factors may disrupt the equilibrium of a giant molecular cloud, triggering a collapse and initiating the burst of star formation that can result in an open cluster.

Many scientists argue that the Permian-Triassic extinction event was caused by a combination of some or all of the hypotheses above and other factors ; the formation of Pangaea decreased the number of coastal habitats and may have contributed to the extinction of many clades.

Many modern theorists have stated that this ideal cannot be achieved independently of some analysis of additional factors.

Many of the assertions put forth and conclusions reached by the authors are very controversial, ranging from the relationships between low measured intelligence and anti-social behavior, to the observed relationship between low African-American test scores ( compared to whites and East Asians ) and genetic factors in intelligence abilities.

Many different factors can cause a spin, including:

Many libraries and museums increasingly use only the safe if confusing term " membrane "; depending on factors such as the method of preparation it may be very hard to determine the animal involved without using a laboratory, and the term avoids the need to distinguish between vellum and parchment.

Many of the bacteria's virulence factors are anti-phagocytic in nature.

Many factors, including the success of brands like Lindemans ( part of Foster's Group ) and Jacob's Creek in the UK, as well as Rosemount in the US and UK, were responsible for a dramatic expansion of plantings during the 1980s and 1990s ; a similar trajectory occurred in California.

Many factors contributed to McCarthyism, some of them extending back to the years of the First Red Scare ( 1917 – 20 ), inspired by Communism's emergence as a recognized political force.

Many people interviewed after the suicide of a relative or friend have a tendency to simplify the issues ; their grief can lead to their minimizing or ignoring significant factors.

Many factors have contributed to the divergence of the official and conventional strike zones in Major League Baseball.

Many of the men on our campus have a pretty set curriculum, especially in the various engineering fields, with few electives till the senior year.

Many statisticians base ANOVA on the design of the experiment, especially on the protocol that specifies the random assignment of treatments to subjects ; the protocol's description of the assignment mechanism should include a specification of the structure of the treatments and of any blocking.

Many species in the iris family have a great economic importance in ornamental horticulture and the cut flower industry, especially Gladiolus, Freesia, Sparaxis, Iris, Tigridia ( tiger lily ), Ixia ( corn lily ), Romulea, Neomarica, Moraea ( butterfly lily ), Nemastylis, Belamcanda, Sisyrinchium ( blue-eyed grass ), Crocosmia and Trimezia.

Many Armenian companies, especially those owned by government-connected tycoons, have long reported suspiciously low earnings, thereby avoiding paying larger taxes.

Many such children live in Sambutsu especially, on the eastern coast.

Many Protestants, especially Calvinists, consider him to be one of the theological fathers of the Protestant Reformation due to his teaching on salvation and divine grace.

Many stories have developed since the founding long ago to become a part of America's folklore and cultural awareness, and non-native American folklore especially includes any narrative which has contributed to the shaping of American values and belief systems.

Many studies now indicate that chronic treatment with antipsychotics affects the brain at a structural level, for example increasing the volume of the basal ganglia ( especially the caudate nucleus ), and reducing cortical grey matter volume in different brain areas.

Many were especially critical of him following his remarks in the South Carolina primary, which Obama won.

Many systems became quite sophisticated in graphic presentation, especially considering that the system was confined to ASCII codes.

Many viral agents have been studied and / or weaponized, including some of the Bunyaviridae ( especially Rift Valley fever virus ), Ebolavirus, many of the Flaviviridae ( especially Japanese encephalitis virus ), Machupo virus, Marburg virus, Variola virus, and Yellow fever virus.

Many quotes from the Book of Job are used throughout Jewish liturgy, especially at funerals and times of mourning.

Many of his sets, especially in street scenes, bear a strong similarity to Kennington, where he grew up.

Many later CPU designs use similar mixed bit width, especially when the processor is meant for general-purpose usage where a reasonable balance of integer and floating point capability is required.

Many folk museums show examples of clothing decorated with cross-stitch, especially from continental Europe and Asia.

Many of the above concepts, especially equivalence of categories, adjoint functor pairs, and functor categories, can be situated into the context of higher-dimensional categories.

Many catalytic processes, especially those used in organic synthesis, require so called " late transition metals ", which include palladium, platinum, gold, ruthenium, rhodium, and iridium.

Many people of Chaoshan origin, also known as Teochiu or Teochew people, have settled in Southeast Asia, especially Singapore, Hong Kong, Cambodia and Thailand ; influences they bring can be noted in the cuisine of Singapore and that of other settlements.

Many scholars employ the term, especially those in the fields of history, cultural studies, and postcolonial theory.

Many historical reenactment groups, especially those whose focus is Antiquity or the Middle Ages, commonly use mail both as practical armour and for costuming.

Many calculators continued to use two or more integrated circuits ( ICs ), especially the scientific and the programmable ones, into the late 1970s.

Many vehicles were destroyed or commandeered by militias, especially in the north and east of the country, and the fuel supply system was also badly affected.

Many phoneticians ( especially those trained in the British school ) resort to it constantly as a quick and convenient form of reference.

Many Protestants ( especially those belonging to the magisterial traditions, such as Lutherans, or those such as Methodists, that broke away from the Anglican Communion ) accept the teachings of the first seven councils but do not ascribe to the councils themselves the same authority as Roman Catholics and the Eastern Orthodox do.