* Marfan syndrome

Although no definite medical proof exists, he was reputed to have been affected by Marfan syndrome.

His seemingly unnatural ability may have been a result of Marfan syndrome.

These include osteogenesis imperfecta, Marfan syndrome, hemochromatosis, hypophosphatasia, glycogen storage diseases, homocystinuria, Ehlers – Danlos syndrome, porphyria, Menkes ' syndrome, epidermolysis bullosa and Gaucher's disease.

Various diseases invoked as possible explanations to his early demise included Marfan syndrome, Wilson-Turner X-linked mental retardation syndrome, Fröhlich syndrome ( adiposogenital dystrophy ), Klinefelter's syndrome, androgen insensitivity syndrome, aromatase excess syndrome in conjunction with sagittal craniosynostosis syndrome, Antley – Bixler syndrome or one of its variants and temporal lobe epilepsy .< ref name =" epilepsy ">

Marfan syndrome ( also called Marfan's syndrome ) is a genetic disorder of the connective tissue.

Because it is dominant, people who have inherited one affected FBN1 gene from either parent will have Marfan syndrome.

Marfan syndrome has a range of expressions, from mild to severe.

Researchers now believe, secondary to mutated fibrillin, excessive TGF-β at the lungs, heart valves, and aorta weakens the tissues and causes the features of Marfan syndrome.

) have been tested in a small sample of young, severely affected Marfan syndrome patients.

The constellation of long limbs, dislocated lenses and the aortic root dilation are generally sufficient to make the diagnosis of Marfan syndrome with reasonable confidence.

Many individuals with Marfan syndrome grow to above-average height.

In addition to affecting height and limb proportions, Marfan syndrome can produce other skeletal anomalies.

In Marfan the dislocation is typically superotemporal whereas in the similar condition homocystinuria, the dislocation is inferonasal.

The signs of regurgitation from prolapse of the mitral or aortic valves ( which control the flow of blood through the heart ) result from cystic medial degeneration of the valves, which is commonly associated with Marfan syndrome ( see mitral valve prolapse, aortic regurgitation ).

Because underlying connective tissue abnormalities cause Marfan syndrome, there is an increased incidence of dehiscence of prosthetic mitral valve.

During pregnancy, even in the absence of preconception cardiovascular abnormality, women with Marfan syndrome are at significant risk of aortic dissection, which is often fatal even when rapidly treated.

Marfan syndrome is a risk factor for spontaneous pneumothorax.

Marfan syndrome is caused by mutations in the FBN1 gene on chromosome 15, which encodes the glycoprotein fibrillin-1, a component of the extracellular matrix.

The association between a similar defect and aortic dilatation is well established in such conditions such as Marfan syndrome.

* Weakening of containing membranes or muscles is usually congenital ( which explains part of the tendency of hernias to run in families ), and increases with age ( for example, degeneration of the annulus fibrosus of the intervertebral disc ), but it may be on the basis of other illnesses, such as Ehlers-Danlos syndrome or Marfan syndrome, stretching of muscles during pregnancy, losing weight in obese people, etc., or because of scars from previous surgery.

Dural ectasia is the enlargement of the dura and is common in connective tissue disorders, such as Marfan syndrome and Ehlers – Danlos syndrome.

It is believed that her aneurysm, located on her aorta, resulted from a genetic disorder called Marfan syndrome.

Pectus excavatum is also a relatively common symptom of Marfan syndrome.

Taylor is not afflicted with Marfan syndrome or any other kind of overgrowth syndrome, but instead she is simply extremely tall.

It is sometimes associated with Marfan syndrome or Loeys-Dietz syndrome, but may also result from Ehlers-Danlos syndrome, atherosclerosis, syphilis, cystic medial necrosis, chest injury, or infective endocarditis.

Once rupture occurs, the mortality rate is 50 – 80 %, and most deaths in patients with the Marfan syndrome are the result of aortic disease.

There is an association between familial thoracic aortic aneurysm, Marfan syndrome and massive baclofen overdose as well as other hereditary connective tissue disorders.

Deviated septum is associated with genetic connective tissue disorders such as Marfan syndrome and Ehlers-Danlos Syndrome.

Inheritable connective tissue disorders associated with joint hypermobility ( such as Marfan syndrome and Ehlers-Danlos syndrome types I-III, VII, and XI ), the joint laxity usually is apparent before adulthood.

Further eponymous medical conditions named after Antoine Marfan include:

* Antoine Marfan first describes the symptoms of Marfan syndrome.

Antoine Marfan ; portrait by Henry Bataille

Antoine Bernard-Jean Marfan ( June 23, 1858, Castelnaudary – February 11, 1942, Paris ) was a French pediatrician.

He was born in Castelnaudary ( département Aude, Languedoc-Roussillon ) to Antoine Prosper Marfan and Adélaïde Thuries.

de: Antoine Marfan

es: Antoine Marfan

fr: Antoine Marfan

it: Antoine Marfan

nl: Antoine Marfan

pl: Antoine Marfan

sv: Antoine Bernard-Jean Marfan

* Antoine Marfan ( 1858 – 1942 ), pediatrician

* Honored with 2004 Antoine Marfan Award for innovative and outstanding contributions to the development of cardiovascular surgery and the surgical care of people with the Marfan syndrome.