Masachika Ichimura voiced Mewtwo in Japanese, and the creature's younger self is voiced by Fujiko Takimoto in the Sound Picture Box: Mewtwo's Origin CD drama and Showtaro Morikubo in the anime adaptation.

In the original games, Mewtwo is intended to be " the strongest Pokémon ever ".

As a character in the games, Mewtwo seldom has spoken dialogue, but when it does it is presented as vicious and primarily interested in proving its own strength.

The player is later given an opportunity to capture Mewtwo in the Cerulean Cave, which is accessible only after defeating the game's final bosses, the Elite Four and Blue ; in the remake titles Pokémon FireRed and LeafGreen this prerequisite was expanded, requiring the player to explore more thoroughly and record information on sixty Pokémon species before access to the cave would be granted.

Mewtwo is catchable in Pokémon HeartGold and SoulSilver in the same location as before after defeating all 8 Kanto Gym Leaders.

For all appearances in which the character has spoken dialogue, Mewtwo is voiced by Masachika Ichimura, with the exception of Pokémon Puzzle League, where it is voiced by Phillip Bartlett.

Once it does so, Mewtwo forces the originals to battle the clones in an effort to determine which set is superior, while Mewtwo faces its own original, Mew.

In the film, Mewtwo is voiced by Phillip Bartlett in English, and by Ichimura in Japanese.

Created by scientist Dr. Fuji, Mewtwo is one of several cloning attempts, amongst which includes a clone of Fuji's deceased daughter.

Mewtwo also appears in the musical Pokémon Live !, a live action adaptation of the anime set after Pokémon: The First Movie, and is portrayed by Marton Fulop.

In the manga series Pokémon Adventures, Team Rocket creates Mewtwo, but some of his DNA is placed inside of the Gym leader Blaine.

Because of the DNA that they share, the two are unable to be separated for very long without becoming ill. Later, another Pokémon, Entei is able to break the bond between the two by removing the DNA in Blaine's arm, at which point Mewtwo leaves.

Once captured by Team Rocket, Fuji tells Mewtwo that he is honored by the statement, and is then killed.

In the games, Mewtwo is consistently noted as being one of the strongest opponents, and has been described in Pokémon Red and Blue as being " the best Pokémon in the game ", as well as " one of the rarest — and hardest to catch ".

Like Mewtwo, Mew is a Psychic-type Pokémon with high stats.

It is a legendary Pokémon from the first generation, along with Articuno, Zapdos, Moltres, and Mewtwo.

Mew's number in the National Pokédex is 151, the last of the first-generation Pokémon, with 150 being Mewtwo and 152 being Chikorita.

In the first generation games and their remakes, the player can find journal entries in the Pokémon Mansion on Cinnabar Island stating that Mew was discovered deep in the jungles of Guyana, South America, on July 5 ( the year is not specified ), and named on July 10, and that it " gave birth " to Mewtwo on February 6.

It is thought of as the strongest Pokémon by some, including its clone, Mewtwo.

Other games, such as Super Smash Bros. Melee and the Pokémon Mystery Dungeon series have featured Mewtwo as an unlockable player character that must be defeated before it may be used, while games such as Pokémon Snap have featured the character in cameos, appearing once certain conditions have been met.

: Pokémon Tales Movie Special, which featured children taking on traits of the characters from the film, including Mewtwo.

In May 2001, Viz released a second children's book, Mewtwo's Watching You !, which featured a shy Mewtwo interestedly watching other Pokémon play.

The cards featured likenesses of Electabuzz, Pikachu, Mewtwo, and Dragonite, and were dispensed in random order for each week it was in that particular theater.

In September 1999, Nintendo published Sound Picture Box Mewtwo, which included Myutsuu No Tanjou: Pocket-Monster Radio Drama ( Birth of Mewtwo: Pokémon Radio Drama ), a CD drama that expands upon Mewtwo's origins.

The 52-page comic, presented in the form of a flashback, was replaced midway by the " The Birth of Mewtwo " animated short, resulting in little connection between Ono's work and the film.

In December 2000, the film was followed by a sequel, Pokémon: Mewtwo Returns, which was broadcast on Japanese television in December 2000 and released worldwide on home video and DVD in 2001.

However, Giovanni, whose memories were left intact after the first film, locates and pursues Mewtwo.

To save the traumatized Mewtwo, Fuji erases its memories and puts it under sedation until its body finishes developing, leading to the events of the film.

: 100 Must-See Japanese Animation Masterpieces praised the character as the best villain of the Pokémon film series, and one of Mewtwo Strikes Backs strongest elements.

Mew's first film appearance was in Pokémon: The First Movie as a main character alongside Mewtwo.

This was the second Pokémon film ( the first being Mewtwo Returns ) to be released directly to DVD and VHS in the US.

is a 21-minute short film that is shown before Mewtwo Strikes Back in both the theatrical, VHS and the DVD version of the main film.

* Masachika Ichimura ( Phillip Bartlett in the English adaptation ) as Mewtwo, the main antagonist of the film.

The film primarily consists of three segments: Pikachu's Vacation, a 21 minute feature focusing on the most popular Pokémon character Pikachu ; Origin of Mewtwo, a 10 minute featurette that functions as a prologue to the main feature ; and Mewtwo Strikes Back, the main 75 minute film feature.

The featurette was eventually dubbed and restored as a special feature in the U. S. release of the direct-to-video follow-up film sequel Pokémon: Mewtwo Returns as The Uncut Story of Mewtwo's Origin.

fr: Pokémon, le film: Mewtwo contre-attaque

hu: Pokémon: Az első film – Mewtwo visszavág

In the video games, the player can fight and capture Mewtwo to pit it against other Pokémon.

The player first learns of Mewtwo late in Pokémon Red and Blue by reading research documents left in a ruined laboratory on Cinnabar Island.

Regarded as one of the series ' strongest Pokémon, it changed the way players approached the games by forcing them to find ways to counteract those using Mewtwo.

Japanese video game designer Ken Sugimori designed Mewtwo for the first generation of Pocket Monsters games, Red and Green, known outside of Japan as Pokémon Red and Blue.

Until the first Pokémon movie was released in the United States, Mewtwo was rarely referred to as a " clone " in Japanese sources.

Despite being Mew's descendant, Mewtwo directly precedes Mew in the game's numerical Pokémon index owing to the latter's secret inclusion by Game Freak programmer Shigeki Morimoto.

During an interview, Pokémon Company president Tsunekazu Ishihara stated that Mewtwo was expected to be popular with North American audiences, citing their preference for strong, powerful characters.

In Pokémon Stadium and Pokémon Pinball, Mewtwo appears as a final boss after all competitions have been completed.

In Pokémon Puzzle League, Mewtwo serves not only as the final opponent, but also as the main antagonist responsible for the game's events.

The 2006 television special Pokémon: The Mastermind of Mirage Pokémon features a hologram version of Mewtwo, created and controlled by the story's antagonist Dr. Yung.