As one of the top wrestlers in the cruiserweight division, Mysterio would go on to voice his disdain in regards to not being pushed:

They were stripped of the title, however, after Ernest Miller pinned Disco Inferno with the stipulation that if he pinned Disco, Mysterio and Guerrera would be stripped of the title.

Mysterio continued to feud with Raw's World Tag Team Champions, even finding a tag team partner in World Heavyweight Champion Batista who, along with Mysterio, would be set to face Raw's Kane and The Big Show in a tag match at Armageddon.

This led JBL to vow that if he did not win his rematch against Mysterio, he would quit SmackDown !.

In the main event of the evening, Mysterio retained the World Heavyweight Championship, causing JBL to leave SmackDown !, until ECW One Night Stand, when JBL announced he would return as a color commentator.

It was revealed that Mysterio would have to defend his title against ECW wrestler Sabu at One Night Stand.

Mysterio then began a feud with The Great Khali, which would lead to a match at Unforgiven where he would face Khali for the World Heavyweight Championship ; the match was eventually made a Triple Threat match also involving Batista, but was unsuccessful in recapturing the title.

On the February 22 episode of SmackDown !, Mysterio announced that his injury would keep him out of action for at least six months, and he eventually underwent three surgeries within the space of a month.

On August 2, WWE announced that Mysterio would be suspended for 30 days, effective September 2, for violating the company's Wellness Policy.

Later it was announced that Mysterio and Batista would face each other the following week to decide the Number # 1 Contender.

In the weeks following the Elimination Chamber event, Mysterio would continue to get the better of CM Punk, costing him a Money in the Bank qualifying match and defeating SES member Luke Gallows.

Punk later added the stipulation that if Mysterio were to lose at WrestleMania, he would be forced to join the SES.

Five days later on SmackDown, Punk challenged Mysterio to another match at Extreme Rules, with the stipulation that if Mysterio won, Punk would have his head shaved bald.

Mysterio would defeat Rhodes in a rematch on the April 23 edition of Smackdown and at Extreme Rules in a Falls Count Anywhere match to end the feud.

The following night on Raw, Rey Mysterio received a rematch for the WWE Championship against new champion Del Rio, however Del Rio would retain.

On April 26, 2012, WWE reported that Mysterio had been suspended for 60 days due to his second violation of the company's Talent Wellness Program policy and that his suspension would expire on June 25.

He would return one week later on the August 31 edition of Smackdown, defeating Cody Rhodes. At Night Of Champions, Mysterio would lose a fatal-four way title match against Sin Cara, Cody Rhodes, and the eventual winner, The Miz. The following day on Raw, Sin Cara and Mysterio teamed up to defeat Epico and Primo in a tag team match, after which they were attacked by the Prime Time Players ( Darren Young and Titus O ' Neil ).

John Cena would go on to retain his WWE Championship at both WrestleMania 22 and 23, while the same events would see Rey Mysterio and The Undertaker win the World Heavyweight Championship respectively.

At One Night Stand, Mysterio retained his title in a match after he and Sabu were ruled unable to continue following a triple jump DDT through a table from Sabu.

At this point, the WWE medical staff rushed to the injured men and declared neither man could continue and ordered the match stopped, resulting in a No Contest in which Mysterio kept his title.

Then Spider-Man leaves OsCorp through an elevator to continue his search for Doc Ock on OsCorp's rooftop before he finds himself in a New York literally torn out of the ground and into the sky by the machinations of the supervillain Mysterio, who has done this to further Ock's plans.

In June 1997, he lost the Cruiserweight Title to Chris Jericho at a non-televised webcast house show in Los Angeles, California minutes after a successful defense against Rey Mysterio, Jr. Syxx then began a feud with Ric Flair, losing to Flair at Road Wild in August.

Mysterio soon began a feud with the New World Order ( nWo ), which culminated when he lost a Mexican Death match to nWo member Konnan at Road Wild in August.

Mysterio then became involved in a feud with his real-life friend and Cruiserweight Champion Eddie Guerrero.

Mysterio's on-and-off tag team partner Billy Kidman joined him during the feud with LWO, wrestling against the LWO despite Mysterio being a part of the group.

He eventually began a feud with Kurt Angle, which culminated in a match at SummerSlam that Angle won after forcing Mysterio to submit to the ankle lock.

Guerrero and Mysterio continued to feud, with Guerrero threatening to reveal a secret he and Mysterio shared involving Mysterio's real life son Dominick, unless Mysterio deferred to Guerrero's authority.

Their feud ended when Guerrero gained a victory over Mysterio in a steel cage match.

The week before the title defense took place saw the start of a feud between the then-United States Champion John " Bradshaw " Layfield and Mysterio.

The feud with JBL saw Mysterio face off against any opponent of JBL's choosing in the three weeks leading up to his title match against Mysterio at Judgment Day.

Mysterio began a feud with King Booker after Booker won a battle royal to become the number one contender for the World Heavyweight Championship.

Mysterio then began a feud with Finlay, an opponent chosen by JBL.

Mysterio began a feud with Kane next which lasted until Survivor Series.

At Survivor Series 2008, Team HBK which consisted of Shawn Michaels ( the team captain ), Rey Mysterio, The Great Khali and Cryme Tyme ( JTG & Shad ) defeated Team JBL ( John Bradshaw Layfield, Kane, Montel Vontavious Porter, John Morrison & The Miz ), thus ending the feud between Kane and Mysterio.

He then began a long-time feud with Chris Jericho, resulting in Mysterio defending and retaining his title at Judgment Day.

In the weeks leading up to the Elimination Chamber, Mysterio began a feud with CM Punk that also involved Punk's Straight Edge Society.

On the August 27 episode of SmackDown, Mysterio lost a No Disqualification match to Kane, and afterwards was attacked by Alberto Del Rio on his injured left arm, sparking a feud between the two.

Paez had a brief supporting role with World Wrestling Entertainment as an associate of Rey Mysterio, and accompanied him to the ring at the No Way Out pay-per-view event on February 15, 2004.

In Asistencia Asesoría y Administración ( AAA ), Mysterio feuded with Juventud Guerrera.

Mysterio commonly teamed with the similarly undersized high flyer known as Romy " Romeo " Magruder.

Mysterio signed with Paul Heyman's Extreme Championship Wrestling ( ECW ) in 1995.

Mysterio also had a series of matches with ECW-newcomer Juventud Guerrera during the first half of 1996.

Mysterio continually refused to join and feuded with Guerrero and the LWO members, including winning a match against longtime rival and LWO member Psicosis in a match at Road Wild.

His alliance with Kidman was formed after Mysterio helped Kidman defeat Juventud for the Cruiserweight Title at World War 3.

The following week, Mysterio and Kidman teamed with each other and defeated Flair's Four Horsemen stablemates Chris Benoit and Dean Malenko to win the WCW World Tag Team Championship, making Mysterio a double champion.

In mid-1999, Mysterio and Konnan joined Master P's No Limit Soldiers, and began feuding with the West Texas Rednecks.

After Master P's departure from WCW, Mysterio formed a stable with Eddie Guerrero and Billy Kidman known as the Filthy Animals.

Billy Kidman substituted for Mysterio and teamed with Konnan during their title defense against Harlem Heat and The First Family, in which the Filthy Animals went on to lose the title back to Harlem Heat.

Mysterio reformed his tag team with Kidman and the two challenged for the World Tag Team Championship in a Triangle match at Halloween Havoc, facing the champions Natural Born Thrillers and the Boogie Knights, where the Thrillers retained.

In June 2002, Mysterio signed with World Wrestling Entertainment ( WWE ), and promos that hyped his debut began airing.

Rey Mysterio had a tag team with Eddie and they were also best friends.

After an unsuccessful attempt at regaining the Cruiserweight Title, Mysterio formed a tag team with Rob Van Dam, and went on to win the Tag Team Championship from Kenzo Suzuki and René Dupreé on the December 9 episode of SmackDown !.

Mysterio then teamed up with Eddie Guerrero to win the Tag Team Championship back from the Bashams at No Way Out.

Then after a no disqualification match against Chavo, Eddie came out and slammed Mysterio on the steel steps, displaying Eddie's increasing frustration with being unable to defeat Mysterio.