Once bound, β-arrestins both sterically prevent G-protein coupling and may recruit other proteins leading to the creation of signaling complexes involved in extracellular-signal regulated kinase ( ERK ) pathway activation or receptor endocytosis ( internalization ).

Once again, Sir Henry Vane was the leading catalyst for the republican cause in opposition to force by the military.

Once again Carey's late season form was unparalleled, and in the nine games leading up to the Grand Final he averaged 8 marks, 19 disposals and 5. 1 goals per game.

Once swallowed, this plastic can cause a general decline in the fitness of the bird, or in some cases lodge in the gut and cause a blockage, leading to death by starvation.

Once released, Patel served as interim Congress president, but was re-arrested while leading a procession in Mumbai.

Once again, the theme was rescored, this time using a prominently heard Moog synthesizer leading the acoustic instruments, and the rhythm cut to half-time.

Once Vietnam did succumb to foreign rule, however, it proved unable to escape from it, and for 1, 100 years, Vietnam had been successively governed by a series of foreign powers: the Hans, Eastern Hans, Eastern Wus, Cao Wei, Jins, Liu Songs, Southern Qis, Liangs, Suis, Tangs, and Southern Hans ; leading to the losses of its writing system, language, and national identity.

Once the show hit its stride, they had leading roles in the RKO Radio Pictures films Look Who's Laughing ( 1941 ), Here We Go Again ( 1942 ), and Heavenly Days ( 1944 ).

Once the case became internationally known the family sought a well known lawyer and retained < span class =" plainlinks "> Isidore Franckel </ span > one of Paris's leading advocates and President of the Central Committee of the Alliance of Revisionists-Zionists, also known as Hatzohar.

Once in his post he offended the religious sensibilities of his subjects, leading to harsh criticism from Philo and Josephus.

Once these divisions were ready, the rest of the corps would withdraw towards them, luring the allies to attack, while Napoleon, leading the main 110, 000 strong French force, would come around the allied flank and counter attack.

Once a critical volume of magma and gas accumulates, the obstacle ( rock blockage ) of the volcanic cone is overcome, leading to a sudden explosive eruption.

Once a predominantly agricultural country, Yugoslavia was transformed into a mid-range industrial country, and acquired an international political reputation by supporting the decolonization process and by assuming a leading role in the Non-Aligned Movement.

Once General Tire sold the network in 1957, Mutual's ownership was largely disconnected from the stations it served, leading to a more conventional, top-down model of program production and distribution.

Once elected, Councillors remain members of their political parties, but hold no leading office with them.

Once in London, he quickly gained a reputation as a formidable player on flute, alto and tenor saxophone, leading to a regular gig at Ronnie Scott's nightclub.

Once swallowed, this plastic can cause a general decline in the fitness of the bird, or in some cases lodge in the gut and cause a blockage, leading to death by starvation.

Once young men began working in mines and other colonial businesses, they gained the means to increase the lobolo, leading elders to increase the value required for lobolo in order to maintain their control.

Once again she was arrested, served some time in prison and was escorted from the state in the months leading up to the Ludlow Massacre.

Once a deprived area, it became a leading part of a self sustainable project providing much needed income to locals.

Once Canada had a formally recognized position in London, the High Commissioner in 1880, this person also became Canada's leading voice to all of Europe.

Once the infancy of Henry III ended and he took full control of the government of his kingdom, many leading nobles became increasingly concerned at his style of government, specifically his unwillingness to consult them on the decisions he took and his perceived willingness to bestow patronage upon his foreign relatives in preference to his native subjects.

Once elected Cameron began discussions with right-wing and eurosceptic parties in other European countries, mainly in eastern Europe, and in July 2006 he concluded an agreement to form the Movement for European Reform with the Czech Civic Democratic Party, leading to the formation of a new European Parliament group, the European Conservatives and Reformists, in 2009 after the European Parliament elections.

Once the potassium has been significantly reduced by aldosterone, a sodium / hydrogen pump in the nephron becomes more active leading to increased excretion of hydrogen ions and further exacerbating the hypernatremia.

Once the gold rush started, the city was founded ( 1876 ) at the mouth of Spearfish Canyon, and Spearfish grew as a supplier of foodstuffs to the mining camps in the hills.

Once the contract is awarded to the supplier, the relationship between customer and supplier changes from a competitive environment to a monopoly / monopsony relationship, known as a bilateral monopoly.

Once inventory is managed as described above, continuous efforts should be undertaken to reduce RT, late deliveries, supplier minimum order quantities ( both per SKU and per order ) and customer order batching.

Once again, Tom Horn was the first and most likely suspect, and he was brought in for questioning immediately.

Once and for all he'd finish this marine who would not die.

Once inside the luxuriosly-upholstered landau, she drew the curtains and proceeded to give the startled youth the kind of physical examination usually reserved for army inductees.

Once, then -- for how many years or how few does not matter -- my world was bound round by fences, when I was too small to reach the apple tree bough, to twist my knee over it and pull myself up.

Once more, in other words, Steele is said to be indebted to Swift for his `` wit '' ; ;

Once, they were at Easthampton for the summer ( again, Fritzie said, a good place, even though they were being robbed ).

Once we have made clear that we are genuinely concerned with a country's development potential, we can be blunt in suggesting the technical conditions that must be met for development to occur.

Once on the water, these little visitors seldom leave, and this adds to your filtering and vacuuming problems as well as providing a slapping good time for all those present.

Once he disposed of these items which screamed so harshly for attention, he could undertake the things which really counted.

Once many significant phrases are found in theory or in recurrent practice to provide for prosodic necessity, they are not to be defended for their semantic properties in isolated contexts.

Once, after the Discovery lay for a week in rough weather, Hudson ordered the anchor raised before the sea had calmed.

Once he had abandoned himself to the very worst, once he had quieted all the dragons of worry and suspense, there wouldn't be very much for Mae to do.

Once a movement per unit time is observed, astronomers compensate for the parallax caused by the earth ’ s motion during this time and the heliocentric distance to this object is calculated.

Once seen, Artemis punished Actaeon: she forbade him speech — if he tried to speak, he would be changed into a stag — for the unlucky profanation of her virginity's mystery.

Once there, his way of life took a turn for the better.

Once inside, they pressurized the LM cabin, went through a half-hour briefing with scientists in mission control, and configured the cabin for the sleep period.

Once again, Panipat was the scene of a confrontation between two warring contenders for control of northern India.

Once this condition is met, it is sufficient that local bonding at the specimen surface is capable of being overcome by the field, allowing for evaporation of an atom from the surface to which it is otherwise bonded.

Once images have been acquired, the effects of decay and taphonomy must be accounted for before a correct anatomical reconstruction can be made.

Once a beaver has sounded the alarm, nearby beavers will dive and may not reemerge for some time.

Once again, however, there is a lack of archaeological proof for this reconstruction, and the sheer number of brochs, sometimes in places with a lack of good land, makes it problematic.

Once the keys had been pressed they were locked down until mechanical contacts in a distributor unit passed over the sector connected to that particular keyboard, when the keyboard was unlocked ready for the next character to be entered, with an audible click ( known as the " cadence signal ") to warn the operator.

Once published by BSI a PAS has all the functionality of a British Standard for the purposes of creating schemes such as management systems and product benchmarks as well as codes of practice.

Once the price of inkjet printers dropped to the point where they were competitive with dot matrix printers, dot matrix printers began to fall out of favor for general use.