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Over the course of 30 to 50 years, these aggregates accumulate and have a cytotoxic effect, eventually resulting in the neurodegenerative symptoms associated with SBMA.
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Over and course
Over the years, enlivened chiefly by disputes about the relative merits of Maine and Idaho potatoes, the menu has pursued its drab all-American course.
Over the course of twenty years, Carnegie ’ s steel properties grew to include the Edgar Thomson Steel Works, the Lucy Furnace Works, the Union Iron Mills, the Homestead Works, the Keystone Bridge Works, the Hartman Steel Works, the Frick Coke Company, and the Scotia ore mines among many other industry related assets.
Over the course of military history, projectiles were manufactured from a wide variety of materials, made in a wide variety of shapes, and used different means of inflicting physical damage and casualties to defeat specific types of targets.
Over the course of the 19th and early 20th centuries, these amalgamated or were bought by competitors until only a handful of larger companies remained ( see railway mania ).
Over the course of the disease, the thyroid glands greatly enlarge ( up to 10 x 20 cm ) and may become polycystic.
Over the course of the Classical period, " symphonies " and concertos developed and were presented independently of vocal music.
Over the course of three more voyages, Columbus visited the Greater and Lesser Antilles, as well as the Caribbean coast of Venezuela and Central America, claiming them for the Spanish Empire.
" Over the course of Hole's career, the band experimented with several different styles, from punk to noise rock as well as more mellow alternative rock, power pop, and folk techniques.
Over the course of hundreds and thousands of years, words may change their sound completely.
Over the course of six to nine million years, as the Challenger Deep grew to its present depth, many of the species present in the sediment died out or were unable to adapt to the increasing water pressure and changing environment.
Over the course of the next couple of hours, the marine hears assorted garbled radio messages, gunfire, and screams, followed by silence: " Seems your buddies are dead.
Over the course of the 20th century, Domitian's military, administrative and economic policies were re-evaluated.
Over the course of multiple re-takes the actor will repeatedly perform the lines while watching the scene, and the most suitable take will make it to the final version of the scene.
Over the course of his career he raised over US $ 5, 000, 000 in support of musicians pension funds.
Over the course of time, though, they began behaving in various unskillful ways.
Over the course of the Middle Kingdom, however, he was displaced in that role by Amun, who may have arisen elsewhere.
Over the course of the Old Kingdom ( c. 2686 – 2181 BC ), however, he came to be more closely associated with the daily rebirth of the sun god Ra and with the underworld ruler Osiris as those deities grew more important.
Over the course of the Middle and New Kingdoms, the notion that the akh could also travel in the world of the living, and to some degree magically affect events there, became increasingly prevalent.
Over the course of the 20th century it became increasingly common for first ladies to select specific causes to promote, usually ones that are not politically divisive.
Over the course of history, the geographical territory that was called " Flanders " has varied.
Captain Beatty, Montag's fire chief, personally visits him and tells him the story of how books lost their value and where the firemen fit in: Over the course of several decades ( with the starting point being after the American Civil War ), populations grew and people embraced new media, sports, and a quickening pace of life.
Over the course of a year, such disagreements would lead to a constitutional crisis.
Over the course of the preceding one hundred years, Rome had defeated every rival that stood in the way of their domination of the Italian peninsula.
Over the course of the twentieth century, the population of the country grew by a factor of fourteen.
Over the course of the 20th century, the UK gradually implemented tighter regulation of the civilian ownership of firearms through the enactment of the 1968, 1988, 1994 and 1997 Firearms ( Amendment ) Acts < ref >
Over and 30
Over the last 30 years, however, the miaphysite position has been accepted as a mere restatement of orthodox belief by Patriarch Bartholomew I of the Eastern Orthodox Church and by Pope John Paul II of the Roman Catholic Church.
Over the past 30 years, the population of the Docklands has more than doubled and the area has become both a major business centre and an increasingly desirable area to live.
Over 30, 000 clay tablets from the Library of Ashurbanipal have been discovered at Nineveh, providing modern scholars with an amazing wealth of Mesopotamian literary, religious and administrative work.
Over the course of the 1988 – 89 television season, his TV show suffered a decline in viewership, resulting in many markets downgrading its time slot ; even flagship station WWOR moved Downey's program from its original 9: 00 PM slot to 11: 30 PM in January 1989, where it was followed by the then-new Arsenio Hall Show.
Over a period of about 30 years, from 1880 to 1910, the nail-making process was almost completely automated.
Over the course of its life, a panga will undergo periodic sex-changes with as much as 30 % of the population being hermaphroditic at a time.
The total length of common-used railway tracks exceeds 85, 500 km, second only to the U. S. Over 44, 000 km of tracks are electrified, which is the largest number in the world, and additionally there are more than 30, 000 km of industrial non-common carrier lines.
Over 30 facilities participate in the red wolf Species Survival Plan and oversee the breeding and reintroduction of over 150 wolves.
Over the past 30 years Sinai has become a tourist destination due to its natural setting, rich coral reefs, and biblical history.
Over 30 editors are at work on future collections.
* May 27 – WWI: Over 30, 000 French troops refuse to go to the trenches in Missy-aux-Bois.
Over 30, 000 people attend the ceremony in Rome, including 140 descendants of Joan of Arc's family.
Over 192, 000 aliens were naturalized between May 9, 1918, and June 30, 1919, under an act of May 9, 1918.
Over 30 types of cnidae are found in different cnidarians.
Over the 30 years after World War II, there were at least 60 center pivot irrigation manufacturers created in the United States.
) Newton-John also continued to reach the Country Top 10 where she tallied seven Top 10 singles through 1976's " Come on Over " ( No. 23 Pop, No. 5 Country, No. 1 AC ) and six consecutive ( of a career nine total ) Top 10 albums through 1976's Don't Stop Believin ' ( No. 30 Pop, No. 7 Country ).
The safety data sheet QGC had submitted for the fracking chemical was derived from the United States, incomplete and 10 years out of date Over 30 chemicals may be used in the process of ' fracking ' and their long term impact on aquifers and the agriculture and people supported by them is unknown.
Over 3, 500 students from over 30 different states and 20 different countries are enrolled at Lewis – Clark State College.
Over 30 species of seabirds and approximately 20 million individuals breed in the Bering Sea region.
Over time it had been reduced to less than an acre ( 4, 000 m² ), and the Pequot population reached a nadir of 20 or 30 in population in the early 20th century.
Over the course of the decade, more than 30 silent film studios were established, earning Jacksonville the title of " Winter Film Capital of the World ".
Over periods of usually many months, they may brighten by between 2. 5 and up to 11 magnitudes ( sixfold to 30 thousandfold change in luminosity ) before fading again.
* Sina. com: Over 30, 000 comments on Wen Jiabao's article on Hu Yaobang.
" Over several years, the prime late evening newscast shifted between 10 and 11 p. m., and between 30 and 60 minutes.
0.158 seconds.