Peptoids with alpha-chiral bulky side chains are known to adopt a Polyproline-type I-like conformation.

Peptoids have been developed as candidates for a range of different biomedical applications, including antimicrobial agents and synthetic lung surfactants, as well as ligands for various proteins including Src Homology 3 ( SH3 domain ), Vascular Endothelial Growth Factor ( VEGF ) receptor 2, and antibody Immunoglobulin G biomarkers for the identification of Alzheimer's disease.

Peptoids, or poly-N-substituted glycines, are a class of peptidomimetics whose side chains are appended to the nitrogen atom of the peptide backbone, rather than to the α-carbons ( as they are in amino acids ).

At first they were only feathers and dark indistinguishable faces and bodies, hunched over their horses' heads.

Two of the new hands, a Mexican named Jose Amado and a kid known only as Laredo, were picked for the first trick of riding night herd.

After the first two murders, the warning notes were rarely ignored.

Even the knowledge that she was losing another boy, as a mother always does when a marriage is made, did not prevent her from having the first carefree, dreamless sleep that she had known since they dropped down the canyon and into Bear Valley, way, way back there when they were crossing those other mountains.

Out of compulsion to say something cheery, Ben Prime blurted, `` Well, we were lucky to be on soft ground when the first floodheads hit.

His political opponent and lifetime friend, Thomas Jefferson, achieved immortality through his authorship of the Declaration of Independence, but equally notable were the legal and constitutional reforms he instituted in his native Virginia, his role as father of our territorial system, and his acquisition of the Louisiana Territory during his first term as President.

This is the primary function of the imagination operating in the absence of the original experiential stimulus by which the images were first appropriated.

Before being daughter, wife, or mother, before being cultured ( a word now bereft both socially and politically of the sheen you children of frontiersmen bestowed on it ), before being sorry for the poor, progressive about public health, and prettily if somewhat imprecisely humanitarian, indeed first and foremost, you were a lady.

Even the first wave of homesickness had passed, although there were moments when Captain Heard pointed out on his compass the direction of Bradford that she felt a little twinge at her heart.

When they were first written, there was evidently no thought of their being published, and those which refer to the writer's love for Mrs. Meynell particularly have the ring of truth.

The evening of our first day we drove with Christopher and Judy Sakellariadis, who were friends and patients of Norton, to dine at a restaurant on the shores of the Aegean.

So persistent were these attacks that in March of the following year, Woodruff was finally moved to action, and Pike was to learn his first lesson in frontier politics, the subtle art of diversion.

In the next few months of comparative silence, Pike waited patiently until conditions were perfect for a new attack, and then, displaying a remarkable grasp of the subtleties of political infighting, gained from his first bout with Woodruff, he used these changed conditions to excellent advantage.

Although this kind of wholesale objection came at first from some men who were not technically Puritans, still, once the Puritans gained power, they climaxed the affair by passing the infamous ordinance of 1642 which decreed that all `` public stage-plays shall cease and be forborne ''.

Our first impression of the data was that the students were surprisingly orthodox and religiously involved.

But all the reports of this first embassy show that the two Savoyards were the heads of it, for they were the only ones who were empowered to swear for the king that he would abide by the pope's decision and who were allowed to appoint deputies in the event that one was unavoidably absent.

the Low Countries, where the Middle Ages were to last for another two centuries and die out only when Charles the Bold of Burgundy met his first defeat in the fields and forests below the walls of Grandson.

It was the first American war in which the death rate from disease was lower than that from battle, due to the provision of trained medical personnel ( of the 200,000 officers, 42,000 were physicians ), compulsory vaccination, rigorous camp sanitation, and adequate hospital facilities.

There were several men of ninety or more whom I knew first or last, all of whom were still productive and most of whom knew one another as if they had naturally come together at the apex of their lives.

It met a serious rebuff in New Orleans, where the two schools selected for the first moves toward integration were boycotted by white parents.

These microfossils indicate the swamp was `` formed during the Lower Cretaceous period when dinosaurs were at their heyday and when the first flowering plants were just appearing.

If there were no West Berlin problem, imperialist quarters would have invented an excuse for stepping up the armaments race to try to solve the internal and external problems besetting the United States and its NATO partners.

" To fill out the schedule, most types of racing events were invented here, including the first hill climb ( Nice – La Turbie ) and a sprint that was, in spirit, the first drag race.

New kinds of transducers ( generators and receivers of acoustic energy ) were invented and put to use.

The huge ratio of length vs cross sectional area coupled with velocity made the arrow orders of magnitude more powerful than any other hand held weapon until firearms were invented.

Donnelly attempted to establish that all known ancient civilizations were descended from Atlantis, which he saw as a technologically sophisticated culture, saying that Atlanteans invented gunpowder and the compass thousands of years before the rest of the world invented written language.

French Beaded Flowers were being made as early as the 16th century, and lampwork glass was invented in the 18th century.

Several components that eventually played a key role in the development of the automobile were invented for the bicycle, including ball bearings, pneumatic tires, chain-driven sprockets, and tension-spoked wheels.

Broughton also invented and encouraged the use of " mufflers ", a form of padded gloves, which were used in training and exhibitions.

In the period between 1904 and 1946 particularly, alternatives or improvements to the fountain pen were invented.

Blissymbols were invented by Charles K. Bliss ( 1897 – 1985 ), born Karl Kasiel Blitz in the Austro-Hungarian city of Czernowitz ( at present the Ukrainian city of Chernivtsi ), which had a mixture of different nationalities that “ hated each other, mainly because they spoke and thought in different languages .”

During the early twentieth century, electro-mechanical machines were invented to do encryption and decryption using transposition, polyalphabetic substitution, and a kind of " additive " substitution.

Although these encryption methods were more complex than previous schemes and required machines to encrypt and decrypt, other machines such as the British Bombe were invented to crack these encryption methods.

Higher level programming languages were not invented until the benefits of being able to reuse software on different kinds of CPUs started to become significantly greater than the costs of writing a compiler.

Numerous opinions and interpretations of Confucianism ( of which many are actually opposed by Confucianism ) were invented.

" Multiambic " keyers for use with wearable computers were invented in Canada in the 1970s.

The specifications were to a great extent inspired by the FLOW-MATIC language invented by Grace Hopper-commonly referred to as " the mother of the COBOL language.

Catapults were invented by the ancient Greeks.

In fact, cash registers were invented for the purpose of eliminating employee theft or embezzlement ; the original name was Incorruptible Cashier.

In 1919, the year tetrodes were invented, William Henry Eccles coined the term diode from the Greek roots di ( from δί ), meaning " two ", and ode ( from ὁδός ), meaning " path ".

Later, copper alembics were invented.

This change was implemented because new dives were being invented too frequently for an annual meeting to accommodate the progress of the sport.

The first widespread distributed systems were local-area networks such as Ethernet that was invented in the 1970s.

According to old German literature, dragoons were invented by Count Ernst von Mansfeld, one of the greatest German military commanders, in the early 1620s.