[permalink] [id link]
Prednisolone ( a glucocorticoid or steroid ) suppresses the immune response, and the steroid-sparing agent azathioprine may replace it once therapeutic effect has been achieved.
from
Wikipedia
Some Related Sentences
Prednisolone and suppresses
Prednisolone suppresses the immune system, but its long-term use at high doses causes a multitude of side effects, including glucose intolerance and diabetes, weight gain, osteoporosis, muscle weakness, hypercholesterolemia, and cataract formation.
Prednisolone and .
Prednisolone and alkylating agents are the most commonly used.
This drug is still used, in combination with Prednisolone, by veterinarians to treat arthritis in animals.
Prednisolone alone is usually inadequate to prevent rejection of a transplanted kidney.
glucocorticoid and steroid
ACTH stimulates secretion of glucocorticoid steroid hormones from adrenal cortex cells especially in the zona fasciculata of the adrenal.
* Glucocorticosteroids are a class of steroid hormones characterised by an ability to bind with the glucocorticoid receptor ( GR ) and trigger similar effects.
Glucocorticoids ( GC ) are a class of steroid hormones that bind to the glucocorticoid receptor ( GR ), which is present in almost every vertebrate animal cell.
The name glucocorticoid ( glucose + cortex + steroid ) derives from their role in the regulation of the metabolism of glucose, their synthesis in the adrenal cortex, and their steroidal structure ( see structure to the right ).
Its in vitro relative binding affinities at human steroid hormone receptors are: 323 % that of progesterone at the progesterone receptor, 58 % that of testosterone at the androgen receptor, 17 % that of aldosterone at the mineralocorticoid receptor, 7. 5 % that of cortisol at the glucocorticoid receptor, and < 0. 02 % that of estradiol at the estrogen receptor.
In these people the defect had the effect of an isolated impairment of sex steroid ( e. g., DHEA in the adrenal, but also gonadal testosterone and estrogens ) synthesis, whereas mineralocorticoid ( e. g., aldosterone ) and glucocorticoid ( e. g., cortisol ) levels remain normal.
Typical medical conditions in which steroid diabetes arises during high-dose glucocorticoid treatment include severe asthma, organ transplantation, cystic fibrosis, inflammatory bowel disease, and induction chemotherapy for leukemia or other cancers.
The diagnostic criteria for steroid diabetes are those of diabetes ( fasting glucoses persistently above 125 mg / dl ( 7 mM ) or random levels above 200 mg / dl ( 11 mM )) occurring in the context of high-dose glucocorticoid therapy.
glucocorticoid and suppresses
Treatment with glucocorticoid suppresses ACTH, returns mineralocorticoid production toward normal, and lowers blood pressure.
glucocorticoid and immune
Various synthetic glucocorticoids are available ; these are used either as replacement therapy in glucocorticoid deficiency or to suppress the immune system.
glucocorticoid and response
The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element.
** the adrenal cortices, which produce glucocorticoid hormones ( mainly cortisol in humans ) in response to stimulation by ACTH.
After a hormone binds to the corresponding receptor, the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to glucocorticoid response elements ( GRE ) in the promoter region of the target genes resulting in the regulation of gene expression.
The LTR ( long terminal repeat ) of MMTV contains a glucocorticoid hormone response element.
glucocorticoid and may
Unlike most other anabolic steroids, THG also binds with high affinity to the glucocorticoid receptor, and while this effect may cause additional weight loss, it is also likely to cause extra side effects such as immunosuppression that are not seen with most other steroids.
If the skin inflammation causes discomfort and itching, glucocorticoid steroids ( such as 1 % hydrocortisone cream ) may be combined with the anti-fungal drug to help prevent further irritation due to the patient scratching the area.
Fludrocortisone, DOCA ( Deoxycorticosterone acetate ), and aldosterone are, by definition, not considered glucocorticoids, although they may have minor glucocorticoid potency, and are included in this table to provide perspective on mineralocorticoid potency.
The reaction may be an expression of idiosyncrasy in a particular patient as many horses receive high dose glucocorticoid into their joints without showing any evidence of clinical laminitis.
glucocorticoid and effect
Dexamethasone and its derivatives are almost pure glucocorticoids, while prednisone and its derivatives have some mineralocorticoid action in addition to the glucocorticoid effect.
Steroidogenesis showing glucocorticoids in green ellipse at right-it is not a strictly bounded group, but a continuum of structures with increasing glucocorticoid effect, with the primary example being cortisol.
In addition, some glucocorticoids have been shown to rapidly inhibit the release of the inflammatory prostaglandin PGE2, this effect is blocked by the glucocorticoid receptor antagonist mifepristone ( RU-486 ) and is not affected by protein synthesis inhibitors.
glucocorticoid and has
Mifepristone is a powerful glucocorticoid receptor antagonist has also rarely been used, but the medication faces considerable controversy due to its use as an abortifacient.
glucocorticoid and been
Oxygen deprivation that occurs as the result of immobilization ( bed rest ), glucocorticoid treatment, and withdrawal of oxygen have all been shown to promote osteocyte apoptosis.
Multiple in vitro substrates for thioredoxin have been identified, including ribonuclease, choriogonadotropins, coagulation factors, glucocorticoid receptor, and insulin.
glucocorticoid and .
Cortisol is the main glucocorticoid under normal conditions and its actions include mobilization of fats, proteins, and carbohydrates, but it does not increase under starvation conditions.
In one study, glucocorticoid receptors in the central nucleus of the amygdala were disrupted in order to better understand the mechanisms of fear and fear conditioning.
The glucocorticoid receptors were inhibited using lentiviral vectors containing Cre-recombinase injected into mice.
Results of this study showed that disruption of the glucocorticoid receptors prevented conditioned fear behavior.
However, a reduction of freezing was observed in the mice that had inhibited glucocorticoid receptors.
An example is the ability of pharmacologic doses of glucocorticoid to suppress inflammation.
The synthetic glucocorticoid prescription drug prednisone is a main candidate after prolonged intake.
The hippocampus contains high levels of glucocorticoid receptors, which make it more vulnerable to long-term stress than most other brain areas.
Increased intracellular levels of the vitamin will lead to a decrease in the transcription of glucocorticoid hormones.
Synthetic glucocorticoids are used in the treatment of joint pain or inflammation ( arthritis ), temporal arteritis, dermatitis, allergic reactions, asthma, hepatitis, systemic lupus erythematosus, inflammatory bowel disease ( ulcerative colitis and Crohn's disease ), sarcoidosis and for glucocorticoid replacement in Addison's disease or other forms of adrenal insufficiency.
Reduction of inflammation through the use of oral glucocorticoids such as, prednisone, followed by long term topical glucocorticoid nasal spray would easily and safely treat the anosmia.
This can be caused by taking glucocorticoid drugs, or diseases that result in excess cortisol, adrenocorticotropic hormone ( ACTH ), or CRH levels.
It is the most common non-iatrogenic cause of Cushing's syndrome, responsible for 70 % of cases excluding glucocorticoid related cases.
Dexamethasone is a glucocorticoid and simulates the effects of cortisol, including negative feedback on the pituitary gland.
The method of cessation of glucocorticoid drugs is variable, and it is unclear whether they should be weaned or simply stopped abruptly.
In the brain, cortisol acts at two types of receptor-mineralocorticoid receptors and glucocorticoid receptors, and these are expressed by many different types of neurons.
Most endocrine hormone s are controlled by a physiology | physiologic negative feedback inhibition loop, such as the glucocorticoid s secreted by the adrenal cortex.
In laboratory and animal trials in 2000, it was shown that both antagonism of RA-mediated growth inhibition and promotion of LCL proliferation were efficiently reversed by the glucocorticoid receptor ( GR ) antagonist RU486.
0.655 seconds.