Tay – Sachs disease is caused by insufficient activity of the enzyme hexosaminidase A. Hexosaminidase A is a vital hydrolytic enzyme, found in the lysosomes, that breaks down phospholipids.

In 2011, researchers have discovered that Pyrimethamine can increase ß-hexosaminidase activity, thus slowing down the progression of Late-Onset Tay – Sachs disease.

Financial giants Merrill Lynch, Goldman Sachs, and Citibank are developing data backup centers using the region's close proximity to major fiber optic lines running down the Eastern Coast of the U. S.

In early 2008 when Canwest and Goldman Sachs purchased Alliance Atlantis, the BBCK website was shut down, however, the block remained until May 12, 2011 when ownership changed hands from Shaw Media to Knowledge Network Corporation.

In late 1995, Patrick Buchanan wrote " ewly installed President Ernesto Zedillo said he needed the cash to pay off bonds held by Citibank and Goldman Sachs, lest the New World Order come crashing down around the ears of its panicked acolytes.

" Sachs also revealed that he was scared about being on the soap: " I nearly turned them down because I was too scared.

Amelia Sachs, his arms and legs, is sent off to every crime scene in hopes to find that one shred of evidence to pin down the killer.

Sachs divided his 5th category into 3 subcategories: 51 = electrically actuated acoustic instruments ; 52 = electrically amplified acoustic instruments ; 53 = instruments in which make sound primarily by way of electrically driven oscillators, such as theremins or synthesizers, which he called radioelectric instruments.

Organizations that fall into the category of " big business " include ExxonMobil, Wal-Mart, Google, Microsoft, General Electric, General Motors, Citigroup and Goldman Sachs.

Later Sachs added a fifth category, electrophones, such as theremins, which produce sound by electronic means.

The fifth top-level group, electrophones category was added by Sachs in 1940, to describe instruments involving electricity.

Present-day ethnomusicologists, such as Margaret Kartomi ( page 173 ), and Ellingson ( PhD dissertation, 1979, p. 544 ) suggest that, in keeping with the spirit of the original Hornbostel Sachs classification scheme, of categorization by what first produces the initial sound in the instrument, that only subcategory 53 should remain in the electrophones category.

The electrophone category was added to the Hornbostel-Sachs musical instrument classification system by Sachs in 1940, to describe instruments involving electricity.

Present-day ethnomusicologists, such as Margaret Kartomi ( page 173 ), and Terry Ellingson ( PhD dissertation, 1979, p. 544 ) suggest that, in keeping with the spirit of the original Hornbostel Sachs classification scheme, if one categorizes instruments by what first produces the initial sound in the instrument, that only subcategory 53 should remain in the electrophones category.

Tay – Sachs disease is classified into several forms, which are differentiated based on the onset age of neurological symptoms.

In The Devil Wears Prada, Andrea Sachs throws her phone into one of the Fontaines de la Concorde.

In 2000, Carlyle entered into a joint venture with Riverstone Holdings, an energy and power focused private equity firm founded by former Goldman Sachs investment bankers.

Hornbostel and Sachs ' criterion for determining which sub-group an instrument falls into is that if the resonator can be removed without destroying the instrument, then it is classified as 31.

The ensuing financial crisis of 2008 saw Goldman Sachs and Morgan Stanley " abandon their status as investment banks " by converting themselves into " traditional bank holding companies ", thereby making themselves eligible to receive billions of dollars each in emergency taxpayer-funded assistance.

Then all five major “ free standing ” investment banks ( i. e., those not part of a bank holding company ) entered bankruptcy proceedings ( Lehman Brothers ), were acquired by bank holding companies ( Bear Stearns by JP Morgan Chase and Merrill Lynch by Bank of America ), or became bank holding companies by converting their industrial loan companies (“ nonbank banks ”) into a national ( Morgan Stanley ) or state chartered Federal Reserve member bank ( Goldman Sachs ).

Other translations include those of Paul Béesau ( 1868 ), Gaston Pérot ( 1902, in verse ), Nata Minor ( received the Prix Nelly Sachs, given to the best translation into French of poetry ), Roger Legras, Maurice Colin, Michel Bayat and Jean-Louis Backès ( does not preserve the stanzas ).

A new hospital opened in early 2003, providing service to an area extending from Sachs Harbour on Banks Island, to Ulukhaktok on Victoria Island, and from Paulatuk into the Sahtu Region including Norman Wells, Tulit ' a, Deline, Fort Good Hope, and Colville Lake.

Investment banking firm Goldman Sachs and logistics services provider United Parcel Service ( UPS ) are examples of companies which remained privately held for many years after maturing into profitable companies.

In 1885, Goldman took his son Henry and his son-in-law Ludwig Dreyfuss into the business and the firm adopted its present name, Goldman Sachs & Co.

Although the term shock therapy only came into existence after Bolivia's actions in 1985, both Gonzalo Sánchez de Lozada ( the architect of the policy in Bolivia ) and Jeffrey Sachs ( its economic architect ) were heavily influenced by West Germany's reforms in 1948.

Sachs himself resigned from his post as advisor, after stating that he felt his advice was unheeded and his policy recommendations were not actually put into practice.

A 2010 Rolling Stone article by Matt Taibbi likened investment bank Goldman Sachs to " a great vampire squid wrapped around the face of humanity, relentlessly jamming its blood funnel into anything that smells like money.

Rival private equity firm, Forstmann Little & Co. was invited into the process by Shearson Lehman but attempted to provide a bid for RJR with a consortium of Goldman Sachs Capital Partners, Procter & Gamble, Ralston Purina and Castle & Cooke.

* In the 2006 Fox 2000 Pictures release, The Devil Wears Prada, the protagonist, Andy Sachs ( played by Anne Hathaway ), completes her ugly-duckling-to-swan transformation by strutting confidently into her employer's offices wearing a pair of Chanel black leather thigh boots.

In a November 3, 2011 press release on its website, A & P announced that it had entered into an agreement to receive $ 490 million of debt and equity financing from private investors the Yucaipa Companies, Mount Kellett Capital Management, and investment funds managed by Goldman Sachs Asset Management, subject to approval of the U. S. bankruptcy court.

M. Sachs attempted to render some of Najara's piyyuṭim into German ( Busch, Jahrbücher, 1847, pp. 236 – 238 ).

To that effect, he, along with analysts Connie Sachs and Doc di Salis, look into investigations unreasonably suppressed by Bill Haydon, the identified mole.

He initially sang bass roles but in 1970 expanded into the bass-baritone repertoire and found a particular affinity with Wagnerian roles such as Hans Sachs ( Die Meistersinger von Nürnberg ), Wotan ( Der Ring des Nibelungen ), and The Dutchman ( The Flying Dutchman ).

Friedman, who remains a member of Goldman Sachs ' board, came into violation of Federal Reserve policy when Goldman was converted to a bank holding company in September 2008, thereby placing it under the regulatory authority of the New York Fed.

In December 2006, the series was collected into Sachs and Violens, a 128-page trade paperback by DC Comics.

Adric appears in the Big Finish Productions audio drama The Boy That Time Forgot, and is portrayed by Andrew Sachs, where he was unintentionally saved by Block Transfer Computations subconsciously sent to him by the Doctor during a ' seance '; this caused him to be sent into a pocket dimension based on an Aztec jungle, populated primarily by giant scorpions and insects.

Annual growth in the economy slowed to 2. 3 % in 2008, and was expected to drop to as low as-4. 5 % by Goldman Sachs, but South Korea was able to limit the downturn to a near standstill at 0. 2 % in 2009.

The opening lines for this poem, addressing the Reformation, were later used by Wagner in Act 3 when the crowd acclaims Sachs:

Many commentators have pointed out that Sachs in his famous Act 3 monologue Wahn, Wahn, überall Wahn is paraphrasing Schopenhauer when he describes the way that Wahn, or self-delusion, drives men to behave in ways which are actually destroying them.

The first series began on 3 October 2007 and features Harry Enfield as Dirk, Billy Boyd as Richard, Olivia Colman as Janice, Jim Carter as Gilks, Andrew Sachs as Reg, Felicity Montagu as Susan, Robert Duncan as Gordon, Toby Longworth as the Monk, Michael Fenton Stevens as Michael, Andrew Secombe, Jon Glover, Jeffrey Holland, Wayne Forester and Tamsin Heatley.

According to the International Monetary Fund, Bangladesh ranked as the 43rd largest economy in the world in 2010 in PPP terms and 57th largest in nominal terms, among the Next Eleven or N-11 of Goldman Sachs and D-8 economies, with a gross domestic product of US $ 269. 3 billion in PPP terms and US $ 104. 9 billion in nominal terms.

Under threat of a subpoena by Senator Chuck Grassley, Goldman Sachs revealed that through TARP bailout of AIG, Goldman received $ 12. 9 billion in taxpayer aid ( some through AIG ), $ 4. 3 billion of which was then paid out to 32 entities, including many overseas banks, hedge funds and pensions.

As of 2008, Sturmey-Archer makes 3 -, 5-and 8-speed hubs, SRAM ( successor to Fichtel & Sachs ) make 3 -, 5 -, 7-and 9-speeds and Shimano make 3 -, 7-and 8-speeds.

The Las Vegas Review-Journal published a story on January 3, 2012, that states the LVH is in foreclosure and that lead mortgage holder Goldman Sachs has taken over all operations of the property with the exception of the Casino, which Colony Capital will continue to operate during the foreclosure proceedings.

Berkshire made $ 3. 5 billion on its investment in preferred shares of Goldman Sachs.

Sachs estimates that malaria can be controlled for US $ 3 billion per year, thus suggesting that anti-Malaria projects would be an economically justified investment.

A 1982 BBC Radio 4 broadcast featured Alec McCowen as Orsino, Wendy Murray as Viola, Norman Rodway as Sir Toby Belch, Andrew Sachs as Sir Andrew Aguecheek and Bernard Hepton as Malvolio ; in 1993 BBC Radio 3 broadcast the play, with Michael Maloney as Orsino, Eve Matheson as Viola, Iain Cuthbertson as Malvolio and Joss Ackland as Sir Toby Belch.

Most interesting in these letters ( first published by S. Sachs in the Jahrbuch für Geschichte der Juden 1863 ; 3: 195-224 ) is the fund of information concerning the social and intellectual conditions of the Jews in Greece, Egypt, and Palestine.

In July 2002, TPG, together with Bain Capital and Goldman Sachs Capital Partners, announced the high profile $ 2. 3 billion leveraged buyout of Burger King from Diageo.

Suppliers of red-light cameras in the US include: Affiliated Computer Services ( ACS ) State and Local Solutions, a Xerox company, of Dallas, Texas ; American Traffic Solutions of Scottsdale, Arizona, 1 / 3 owned by Goldman Sachs ; Brekford International Corp., of Hanover, Maryland ; CMA Consulting Services, Inc. of Latham, New York ; Gatso USA of Beverly, Massachusetts ; iTraffic Safety LLC of Ridgeland, South Carolina ; Optotraffic, of Lanham, Maryland ; Redflex Traffic Systems of Phoenix, Arizona, with its parent company in Australia ; RedSpeed-Illinois LLC, of Lombard, Illinois, whose parent company is in Worcestershire, England ; SafeSpeed LLC, of Chicago, Illinois, and SENSYS America Inc., of Miami, Florida.

On May 7, 2009 Friedman resigned as Chairman of the Federal Reserve Bank of New York in response to criticism of his December 2008 purchase of $ 3 million of stock in Goldman Sachs.

In a study of 111 countries in 1970-1989, Sachs and Andrew Warner concluded that the industrialized countries had a growth of 2. 3 %/ year / capita, open economy developing countries 4. 5 % and closed economy developing countries only 2 %.

With more than $ 2. 3 trillion spent in foreign aid over the last half-century and no equivalent impact in reducing poverty and conflict, and new crisis such as the recent famine in the horn of Africa ,< ref > As Jeffrey Sachs wrote in the Guardian, “ the Horn of Africa crisis is a warning to the World ”- see Sachs, J., " The Horn of Africa crisis is a warning to the world.

In July 2002, Bain together with TPG Capital and Goldman Sachs Capital Partners, announced the high profile $ 2. 3 billion leveraged buyout of Burger King from Diageo.

On April 23, 2007 it was announced that American Casino & Entertainment Properties was being sold to Whitehall Street Real Estate Funds an affiliate of Goldman Sachs for $ 1. 3 billion.