When Goro leaves, Sharpless asks Pinkerton if he is really in love.

Sharpless tells Pinkerton that he heard Butterfly speak, when she visited the Consulate, and he asks Pinkerton not to pluck off her delicate wings.

" She turns sharply and asks Sharpless, " Am I correct?

" Sharpless asks her gently, " Butterfly, what would you do if he never returned?

Butterfly shows Sharpless her child, and Sharpless asks if Pinkerton knows.

" She asks Sharpless to write and tell him that his son waits for him.

Pinkerton and Sharpless have arrived, but Pinkerton tells Suzuki not to wake Butterfly and asks how Butterfly knew that Pinkerton had arrived.

She asks Suzuki why she is crying, and then she sees Sharpless and the woman in the garden.

While Pinkerton looks at the flowers, the picture of himself and the room that has remained unchanged for three years, Sharpless tells Suzuki that they can do nothing for Butterfly but that they must help her child.

Sharpless tells her that Pinkerton ’ s new wife, Kate, wants to care for the child.

Pinkerton admits to Sharpless that he does not know whether he is really in love or just infatuated, but he is bewitched with Butterfly ’ s innocence, charm and beauty, like a butterfly fluttering around and then landing with silent grace, so beautiful " that I must have her, even though I injure her butterfly wings ".

However, Pinkerton tells Sharpless that he will do " no great harm, even if Butterfly falls in love.

" Goro re-enters to tell Pinkerton and Sharpless that Butterfly ’ s friends are coming.

Butterfly tells Pinkerton and Sharpless that her family is from Nagasaki and was once very wealthy.

Sharpless greets her, " Excuse me, Madam Butterfly.

" The question confuses Sharpless, so Butterfly explains that Pinkerton promised to return to her " when the robin builds his nest again.

At this, Butterfly hears Goro laugh, and she whispers to Sharpless that Goro is a bad man.

In the meantime, Sharpless gives up trying to read Pinkerton ’ s letter to Butterfly, and he puts the letter back in his pocket.

Goro tells Sharpless that Butterfly thinks that she is still married.

Yamadori, Sharpless and Goro quietly discuss Butterfly ’ s blindness.

Goro whispers that Pinkerton ’ s ship is expected to arrive soon, and Sharpless explains that Pinkerton is too embarrassed to meet Butterfly and has asked Sharpless to handle it.

Sharpless remains, sits next to Butterfly, and takes the letter out of his pocket once more.

Sharpless begins to read Pinkerton ’ s letter to Butterfly: " My friend, will you find that lovely flower of a girl …" Butterfly cannot control her happiness, as he continues, " since that happy times, three years have passed, and Butterfly perhaps does not remember me anymore.

" Sharpless continues, " If she still loves me, if she awaits me, I place myself in your hands so that you may carefully and considerately prepare her …" Butterfly exclaims, " He is coming!

Butterfly is upset with Sharpless and instructs Suzuki to show him out.

Quinine ( and quinidine ) are used as the chiral moiety for the ligands used in Sharpless asymmetric dihydroxylation.

Pinkerton laughs at the sight and whispers to Sharpless, " This is a farce: all these will be my new relatives for only a month.

Noyori shared half of the prize with William S. Knowles for the study of chirally catalyzed hydrogenations ; the second half of the Prize went to K. Barry Sharpless for his study in chirally catalyzed oxidation reactions ( Sharpless epoxidation ).

The most prominent verismo baritones included such major singers in Europe and America as the polished Giuseppe De Luca ( the first Sharpless in Madama Butterfly ), Mario Sammarco ( the first Gerard in Andrea Chénier ), Eugenio Giraldoni ( the first Scarpia in Tosca ), Pasquale Amato ( the first Rance in La fanciulla del West ), Riccardo Stracciari ( noted for his richly attractive timbre ) and Domenico Viglione-Borghesi, whose voice was exceeded in size only by that of the lion-voiced Titta Ruffo.

Finally, the reactants for the Sharpless Epoxidation are commercially available and relatively cheap.

K. Barry Sharpless shared the 2001 Nobel prize in Chemistry for his work on asymmetric oxidations.

The Sharpless Epoxidation has been used for the total synthesis of various carbohydrates, terpenes, leukotrienes, pheromones, and antibiotics.

This reaction was developed principally by K. Barry Sharpless building on the already known racemic Upjohn dihydroxylation, for which he was awarded a share of the 2001 Nobel Prize in Chemistry.

Finally, epoxidizing agents that possess stereogenic structures can influence the stereochemistry of the epoxide product ( see for example the Sharpless epoxidation, Jacobsen epoxidation, Waits – Scheffer epoxidation, and Juliá-Colonna Epoxidation ).

As her story unfolds, Sharpless feels increasing contempt for Pinkerton.

Karl Barry Sharpless ( born 28 April 1941 ) is an American chemist known for his work on stereoselective reactions.

In 2001 he won a half-share of the Nobel Prize in Chemistry for his work on stereoselective oxidation reactions ( Sharpless epoxidation, Sharpless asymmetric dihydroxylation, Sharpless oxyamination ).

Quinidine-based ligands are used in AD-mix-β for Sharpless asymmetric dihydroxylation.

After his defeat for the Senate, Green won admission to the Pennsylvania bar and moved out of his district to the Germantown section of Philadelphia, into the home of his mother-in-law, Margaret Sharpless Kirk, with his wife and children.

A derivative of this molecule is used as chiral ligand in the AD-mix for Sharpless Dihydroxylation.

" Sharpless tells him that, even though he considers the marriage contract a farce, she considers it very real.