* Significant clinical discomfort or impairment at work, social situations, or other important life areas.

Significant biofluid-tissue relationships can be used to prioritize clinical validation of biomarkers.

Significant impairment of visual perception and sedative effects persisting into the next day typically occurs with nitrazepam administration as was demonstrated in a human clinical trial assessing the effect of nitrazepam on peak saccade velocity.

Significant reductions were only seen in clinical trials for hydrocarbon carotenoids.

Significant increases in skin cancers and tumors are found in clinical trial data of the nonbenzodiazepine hypnotics compared to trial subjects who took placebo tablets.

So, after the sitting has been held, several readings at one time are mailed, and the distant sitter ( whose name or whose communicator's name was given to the medium ) must mark each little item as Correct ( Hit ), Incorrect ( Miss ), Doubtful, or Especially Significant ( applying to him and, he feels, not to anyone else ).

Significant complexity is added to the engine by using an air-start system, as the cylinder head must have an extra valve in each cylinder to admit the air in for starting, plus the required control systems.

Significant care must be taken to ensure that Dee does not learn the truth.

Significant events are sometimes left unshown, so that the viewer must piece the information together to gain a full picture.

Significant interests, “ importantly affect the global environment in which the US must act ”.

Significant military loans would be cancelled, and much military property made over to the Kenyan Government.

Significant modernist literary works continued to be created in the 1920s and 1930s, including further novels by Marcel Proust, Virginia Woolf, Robert Musil, and Dorothy Richardson.

Significant cave art sites off the coast of western Europe such as the Grotto Cosquer can be reached only by diving, because the cave entrances are underwater, though the upper portions of the caves themselves are not flooded.

Significant lowlands are to be found only near the coast, in the southwest near Arta and Preveza, in the Acheron plain between Paramythia and Fanari, between Igoumenitsa and Sagiada, and also near Saranda.

Significant unrest is now reported to be fermenting in the camps, especially as the United Nations terminates a number of educational and welfare programmes in an effort to force Bhutan and Nepal to come to terms.

Significant exceptions before 1800 can be found in Purcell's works, German opera of Hamburg during the Baroque, ballad opera and Singspiel of the 18th century, etc.

Significant too is, where Jesus heals a man in a process that is slow and involves saliva ; Mark Goodacre suggests both these features make it a passage more likely to be omitted than added, implying Mark wrote first.

Significant recent spacecraft are the NASA-ESA Solar-Terrestrial Relations Observatory ( STEREO ) pair of spacecraft launch in 2006 into solar orbit and Radiation Belt Storm Probes ( RBSP ) to be launch in 2012 into a highly elliptical Earth-orbit.

Significant dates in this transitional phase from medieval to early modern Europe can be noted:

Significant amendments may be made at committee stage.

Significant wildlife can be found here ( deer, roe deer, boar ), as well as the birdlife is also valuable ( pheasant, eagle ).

Significant differences may be found in ritual behavior related to geographic differences of Lacandon villages.

* Significant measures are taken for beautification of the temple town and the musical fountain present in back side of the temple can be one of the key attractions

Significant quantities of iron may be transported in this way including the well-documented transfer of iron-rich rainfall falling in Brazil derived from sand-storms in the Sahara in north Africa.

Significant suspension modifications may correspondingly require that the upper control arm or strut mounting points be altered to allow for some inward or outward movement, relative to longitudinal centerline of the vehicle, for camber adjustment.

Bloom's Taxonomy is considered to be a foundational and essential element within the education community as evidenced in the 1981 survey Significant writings that have influenced the curriculum: 1906-1981, by H. G.

Significant proton radiation exposure can be experienced by astronauts who are outside of the protective shield of the Earth's magnetosphere, such as an astronaut in-transit to, or located on the Moon.

Owens Lake is still considered to be a Nationally Significant Bird Area by the Audubon California even though Owens is now a mostly dry lake.

Significant noise reduction can be achieved by installing a second interior window.

Significant dates in the winter are sundown ( last day when the sun can be seen ) on Apr 29, midwinter ( June 21 ) and sunup ( first day when the sun rises after winter ) on Aug 13.

Significant popular support for a person who had never previously been involved in politics may be seen as a form of " protest vote ".

Significant Macedonian communities can also be found in the traditional immigrant-receiving nations, as well as in Western European countries.

Significant expansions are also common on all terrace homes ; roofs and additional rooms may be added within the floorspace of the house's lot.

The Fermi-1 commercial fast reactor prototype used HEU with 26. 5 % < sup > 235 </ sup > U. Significant quantities of HEU are used in the production of medical isotopes, for example molybdenum-99 for technetium-99m generators.

Significant tonnage of rubber is used as adhesives in many manufacturing industries and products, although the two most noticeable are the paper and the carpet industries.

Significant evidence of this mining activity remains in the cave, including evidence of large amounts of saltpeter-bearing dirt that were removed, pick marks in the dirt, and an elaborate system of trails used by the miners.

Significant other ( SO ) is colloquially used as a gender-blind term for a person's partner in an intimate relationship without disclosing or presuming anything about marital status, relationship status, or sexual orientation, as it is vague enough to avoid offense by using a term that an individual might consider inappropriate ( e. g. lover when he considers him a boyfriend, or girlfriend when he considers her a life partner ).

Significant recent efforts in fume hood and ventilation system design have focused on reducing the energy used to operate fume hoods and their supporting ventilation systems.

" Significant revisions were also made to the suspension to improve the handling: dampers from Bilstein and coil springs from Eibach are used in addition to reducing the ride height by and an increase in spring rate of 60 %.

Significant changes are the improvement of the rear sight form transitioning from a V-notch type like those on a Type 38, to an aperture, the front sight blade was renewed to a triangular shape, chrome-lined barrels were used, and on earlier productions, the rear sight was equipped with anti-aircraft calipers.

Significant acreage of land previously used for agriculture has been developed for the construction of houses and residential structures.

Significant resources and sophisticated programs are used to analyze and manage risk.

Significant spin-offs include the Atlan series and the Planetenromane (" Planet Novels ") paperbacks that provide additional playgrounds for stories set in the Perry Rhodan universe, often used to fill in the gaps between the ' cycles ' of stories.

Significant elements of sado-masochism were present in some examples, perhaps reflecting the influence of the English public school, where flagellation was routinely used as a punishment.

During the touring in support of Significant Other, Borland used two custom Ibanez RG seven-strings with the electronic setup of an Ibanez AX7521 ( two volume knobs and two tone knobs rather than one volume and one tone ).

Significant assumptions or inputs used in the valuation technique requires the use of inputs that are observable in the market.

Significant vehicles in the collection include three command vehicles used by Field Marshal Bernard Law Montgomery, commander of 21st Army Group during the north-west Europe campaign.

Significant figures are used extensively in high school and undergraduate courses as a shorthand for the precision with which a measurement is known.

Significant changes from the prior 3200 GT engine were the larger displacement resulting from an increased cylinder bore diameter and the move to a naturally aspirated intake that replaced the twin-turbo approach Maserati had used for the previous 20 years, fundamentally because the powertrain is now Ferrari based.

Significant part numbering systems are easier to use if you are trying to identify an item though the use of its code inside your company rather than a long description ; however, many variations can start to appear when the code is used by other companies, which may be your distributors, and then people can become confused.

Significant redundancy was built into these headsets, as each microphone circuit had two transducers and each receiver had 5 transducers — in addition, the headsets were used in pairs.

Significant legislation in the second year included creating the province's first debt-cap for university students, a tax reduction for small business, an Auditor General Act giving that office more power and access to information, an indefinite moratorium on oil and gas exploration on Georges Bank, and Canada's first " Lemon Law " which requires used car dealers to give buyers more information.