Since the 1840s, Kier's salt wells were becoming fouled with petroleum.

Since early in the 1840s the topic of a transcontinental railroad had been discussed.

Since the 1840s, Lincoln, an admirer of Clay, had been an advocate of the ACS program of colonizing blacks in Liberia.

Since being invented in London in the 1840s, Christmas crackers are an integral part of Christmas celebrations, often pulled before or after dinner, or at parties.

Since the creation of perforation devices in the 1840s and 1850s, it has seen use in several areas.

Since the 1840s responsible government has been in place and the position of Premier has been formalized.

Since Brazilian economy was based on slavery and sugar, the long depression in the world sugar market aggravated social and racial ills in the 1840s.

Since around the 1840s the dress coat has lacked outside side pockets, but prior to this it took flapped side pockets.

Since the 1840s, the ByWard Market has served as one of the principal hubs of commerce, entertainment and leisure activities in a locale that has been transformed from a remote colonial outpost to the centre of Canada's National Capital Region.

Since the 1840s, as a manufacturer and leader of the Association for the Promotion of Canadian Industry, Workman had been in favour of high protective tariffs.

Since the famine of the 1840s a railway system had been built, allowing food to be transported to the west of Ireland in days instead of months.

Since the Buffaloes had been using the title from the 1840s the Lord Chancellor agreed that no objection would be raised on continued use of the title on the grounds of long usage, provided no act by the Order arose that would disgrace its use.

Since Kilbirnie was not a large town before the 1840s, there is not much written history except for the farms in the area.

Since the town did not expand until the 1840s most families who lived in Kilbirnie had their roots elsewhere and came to Kilbirnie to find work, such as mining and the steelworks.

Since then, many researches have been conducted to modulate steps in gene expression process.

Since he is still in his teens, he's shown at times acting like a typical teenage boy ( such as his facial expression after Emma Frost walks by him in episode 3 ).

Since the simple arithmetic operators are all binary ( at least, in arithmetic contexts ), any prefix representation thereof is unambiguous, and bracketing the prefix expression is unnecessary.

Since the regulation of vascularization in the mature retina involves a balance between endogenous positive growth factors, such as vascular endothelial growth factor ( VEGF ) and inhibitors of angiogenesis, such as pigment epithelium-derived factor ( PEDF ), rAAV-mediated expression of PEDF, angiostatin, and the soluble VEGF receptor sFlt-1, which are all antiangiogenic proteins, have been shown to reduce aberrant vessel formation in animal models.

Since the angles 0 and 2π are the same this would give two different values for the same expression.

Since the flux is defined as an integral of the electric field, this expression of Gauss's law is called the integral form.

Since ΔA << 1, this expression can be approximated by expanding the exponentials in a Taylor series to first-order and then discarding terms of ΔA in comparison with unity and converting from radians to degrees:

Since then, " point of no return " has become an everyday expression, with its aviation origins probably unknown to most speakers.

Since the 1980s, T-shirts have flourished as a form of personal expression.

Since each cell, regardless of cell type, possesses the same genome, determination of cell type must occur at the level of gene expression.

Since, we now have an expression for the Laplace transform of in terms of's Laplace transform:

Since any number multiplied by zero is zero, the expression 0 / 0 has no defined value and is called an indeterminate form.

In field theory, the expression is only shorthand for the formal expression ab < sup >− 1 </ sup >, where b < sup >− 1 </ sup > is the multiplicative inverse of b. Since the field axioms only guarantee the existence of such inverses for nonzero elements, this expression has no meaning when b is zero.

Since an empty sum by definition has no terms, it seems contradictory to talk about its terms ; however in practice there almost always is an expression that describes the terms of a summation, even if the range of summation happens to be empty.

Since this expression is never instantiated in an empty sum, its value is irrelevant ; for instance the harmonic number

Since the structure of a glycan may depend on the expression, activity and accessibility of the different biosynthetic enzymes, it is not possible to use recombinant DNA technology in order to produce large quantities of glycans for structural and functional studies as it is for proteins.

Since it is not easy to produce an electromagnetic expression for the railgun force that is both simple and reasonably accurate, most simple railgun analyses actually used a lumped circuit model to describe the relationship between the driving current and the railgun force.

Since then, the term has come to be used specifically for graphic design for displaying information effectively, rather than just attractively or for artistic expression.

Since then writers have variously said that an expression stands for, designates, refers to, or denotes its reference.

Since there is not a greatest integer, the expression doesn't refer to anything.

Since the product of an element in I with an element in R is in I ( as I is an ideal ), this product expression will be in I, and then ( a + b )< sup > n + m − 1 </ sup > is in I, therefore a + b is in the radical of I.

Since the Governor has no official residence, the expression " corner office ," rather than " Governor's mansion ," is commonly used in the press as a figure of speech for the office of Governor.

Since surveyors like round figures, the method of expression can affect the gradients selected.

Since there was no apparent practical use for such a device at the time, the patent application was most likely simply a precaution in case someone else did find a use for the so-called Edison effect.

Since most of Fuchs ' work on the bomb, including a 1946 patent on a particular model for the weapon, are still classified in the United States, it has been difficult for scholars to fully assess these conclusions.

Since the patent rights of the I. G.

Since a paper describing the algorithm had been published in August 1977, prior to the December 1977 filing date of the patent application, regulations in much of the rest of the world precluded patents elsewhere and only the US patent was granted.

Since Pupin's patent contained a ( less accurate ) formula, AT & T was open to claims of incomplete disclosure.

Since the days of King Louis XIV, the monarch is the fount of all honours in Canada and new orders, decorations, and medals, which form " an integral element of the Crown ," may only be created with the approval of the sovereign through letters patent.

Since National had applied for a patent on the single cone ( US patent # 1, 808, 756 ), Dopyera had to develop an alternative design, which he did by inverting the cone so that rather than having the strings rest on the apex of the cone as the National method did, they rested on a cast aluminum spider that had eight legs sitting on the perimeter of the downward-pointing cone ( US patent # 1, 896, 484 ).

Since it was the local government district that officially held city status under the 1982 letters patent, when it was abolished, it also ceased to be a city.

Since the mid &# 8209 ; 1990s, Monsanto indicates that it has sued 145 individual U. S. farmers for patent infringement and / or breach of contract in connection with its genetically engineered seed.

Since B & O held patent rights and required paying license fees, many other manufacturers refrained from using it too.

Since Savery's patent had not yet run out, Newcomen was forced to come to an arrangement with Savery and operate under the latter's patent, as its term was much longer than any Newcomen could have easily obtained.

Since he did not obtain a patent, Walker received neither fame nor wealth for his invention, but he was able to retire some years before his death.

Since the gas-generator for the 12 cm sjömålsgranat m / 70 was to be manufactured by a company in the USA, the classification " secret " was removed from the patent.

Since IBM deliberately chose not to seek any copyright, trademark, or design patent protection, the Courier typeface cannot now be trademarked or copyrighted and is completely royalty free.

Since the AFL had a patent given in 1990 on the gameplay of " Arena Football " ( mainly the endzone nets ), the PIFL played with mostly the same rules, but without the endzone nets.

Since 2009, the HKIPA has been lobbying the Hong Kong SAR Government to reform the current patent system and the regulation of patent practitioners.

Since patent attorneys are admitted to practice law in a state or territory, they can additionally provide legal services outside the Patent Office if practicing within the jurisdiction they are admitted to practice or if the law of the jurisdiction otherwise permits them to practice although not admitted in that jurisdiction.

Since most early inventors were ordinary people without technological or legal training, it was difficult for them to submit formal patent applications which require the novel features of an invention to be described using words and a number of diagrams.