Both Tay and Sachs reported their first cases among Jewish families.

Thomas Bouch had originally been awarded the contract but he lost it after the Tay bridge Inquiry reported in June 1880.

Despite its location in the interior of Scotland, the vast Loch Tay adjacent to the village provides some insulation from extreme frost-unlike many weather observing sites in this area of Scotland, no month averages a minimum below freezing point, and no temperatures below have been reported since at least 1960.

This cherry-red spot is the same finding that Warren Tay first reported in 1881, when he identified a case of Tay-Sachs disease, and it has the same etiology.

The disease is named after the British ophthalmologist Waren Tay, who in 1881 first described a symptomatic red spot on the retina of the eye, and after the American neurologist Bernard Sachs of Mount Sinai Hospital, New York, who described in 1887 the cellular changes of Tay – Sachs disease and noted an increased disease prevalence in the Eastern European Ashkenazi Jewish population.

Following the collapse of Sir Thomas Bouch's Tay Bridge in 1879, Fowler, William Henry Barlow and Thomas Elliot Harrison were appointed in 1881 to a commission to review Bouch's design for the Forth Railway Bridge.

* Tay ( 1858 – 1881 )

For most of the first fifteen years of her life, Beatrix spent summer holidays at Dalguise, an estate on the River Tay in Perthshire, Scotland.

In March 1309, he held his first Parliament at St. Andrews, and by August, he controlled all of Scotland north of the River Tay.

* July 22 – The foundation stone of the first Tay Rail Bridge is laid ; the bridge collapses in a storm eight years later.

Infants with Tay – Sachs disease appear to develop normally for the first six months after birth.

A rare form of this disease, known as Adult-Onset or Late-Onset Tay – Sachs disease, usually has its first symptoms during the 30s or 40s.

In the 1960s and early 1970s, when the biochemical basis of Tay – Sachs disease was first becoming known, no mutations had been sequenced directly for genetic diseases.

Because Tay – Sachs was one of the first genetic disorders for which widespread genetic screening was possible, it is one of the first genetic disorders in which the prevalence of compound heterozygosity has been demonstrated.

Tay – Sachs disease was one of the first genetic disorders for which epidemiology was studied using molecular data.

The success with Tay – Sachs disease has led Israel to become the first country that offers free genetic screening and counseling for all couples.

Because Tay – Sachs disease was one of the first autosomal recessive genetic disorders for which there was an enzyme assay test ( prior to polymerase chain reaction testing methods ), it was intensely studied as a model for all such diseases, and researchers sought evidence of a selective process.

The Tay – Sachs model provided by the Jacob sheep is the first to offer promise as a means for gene therapy clinical trials, which may prove useful for disease treatment in humans.

* George W. Petrie Jr., Major, United States Army ( Retired ), a Green Beret, first man on the ground on the Son Tay Raid to rescue prisoners of war held in North Vietnam in 1970 ; Caldwell County's most decorated soldier of the Vietnam war ; planned and coordinated the Evacuation of Saigon, last U. S. Army Special Forces Officer to leave South Vietnam during the Fall of Saigon, April 30, 1975 ; two time recipient of the Silver Star.

Although he was acting on behalf of Thomas Bouch, the builder of the first railway bridge across the Tay, he performed his role with independence and tenacity.

He was knighted after the successful completion of the first Tay Railway Bridge but his name is chiefly remembered for the subsequent Tay Bridge Disaster, in which 75 people are believed to have died as a result of defects in design, construction and maintenance, for all of which Bouch was held responsible.

He designed the first Tay Rail Bridge whilst working for the North British Railway, and the official opening took place in May 1878.

A. J. Cronin's first novel, Hatter's Castle ( 1931 ), includes a scene involving the Tay Bridge Disaster, and the 1942 filmed version of the book recreates the bridge's catastrophic collapse.

The river has a variety of names in its upper catchment: for the first few miles it is known as the River Connonish ; then the River Fillan ; the name then changes to the River Dochart until it flows into Loch Tay at Killin.

The first Eurasian Beaver ( Castor fiber ) living wild in Scotland in over 400 years was captured in the River Tay in 2007 because it may have been illegally released or not of the proper genetic stock.

He thought that pressures no greater than about 10 pounds per square foot could be expected, a comment Bouch took to mean also applied to the first Tay railway bridge then being built.

The largest rod caught salmon in Britain, caught on the Tay by Miss Georgina Ballantine in 1922, weighing 64 lbs, retains the British record.

" The Tay Bridge Disaster " is a poem written in 1880 by the Scottish poet, William McGonagall, who has been widely acclaimed as the worst poet in British history.

In the early 1870s, construction began on the North British Railway's Tay Bridge which cut journey times between Dundee and St Andrews enormously and allowed for a third option between the status quo and complete movement: the creation of what was foreseen as a " University of Dundee and St Andrews ", situated between two campuses, each with their own particular specialities.

* Warren Tay, British ophthalmologist

* June 1-The North British Railway's Tay Bridge across the Firth of Tay in Scotland, is opened to public traffic, making it the longest in the world at that date.

* December 28 – The North British Railway's Tay Bridge across the Firth of Tay in Scotland collapses in a violent storm while a passenger train is crossing it.

* April 20 – The North British Railway's Tay Bridge across the Firth of Tay in Scotland, reconstructed after its collapse in 1879, is reopened and then shortly closed thereafter.

In the opinion of the British observer William Mesny, a senior officer in the Chinese army, the fighting at Son Tay broke the power of the Black Flag Army, though the stubborn defence put up by the Black Flags in the Battle of Hoa Moc fifteen months later does not bear out this assessment.

* George Edson Dutton: The Tay Son Uprising: Society and Rebellion in Eighteenth-Century Vietnam.

Crannogs have been variously interpreted as free-standing wooden structures, as at Loch Tay, although more commonly they exist as brush, stone or timber mounds which can be revetted with timber piles.

In 839, a large Norse fleet invaded via the River Tay and River Earn, both of which were highly navigable, and reached into the heart of the Pictish kingdom of Fortriu.

He wrote about 200 poems, including his infamous " The Tay Bridge Disaster ", which are widely regarded as some of the worst in English literature.

Of the 200 or so poems that he wrote, the most famous is probably " The Tay Bridge Disaster ", which recounts the events of the evening of 28 December 1879, when, during a severe gale, the Tay Rail Bridge near Dundee collapsed as a train was passing over it.

A ganglioside is a form of sphingolipid, which makes Tay – Sachs disease a member of the sphingolipidoses.

Tay – Sachs disease is classified into several forms, which are differentiated based on the onset age of neurological symptoms.

Tay – Sachs results from mutations in the HEXA gene on human chromosome 15, which encodes the alpha-subunit of beta-N-acetylhexosaminidase A, a lysosomal enzyme.

Perth's Pictish name, and some archaeological evidence, indicate that there must have been a settlement here from earlier times, probably at a point where a river crossing or crossings coincided with a slightly raised natural mound on the west bank of the Tay ( which at Perth flows north-south ), thus giving some protection for settlement from the frequent flooding.

Dundee's new waterfront development is seeing the demolition of Tay House ( which stood for less than 50 years ) and a re-alignment of the Tay bridge ramps.

The Firth of Tay ( Scottish Gaelic: Linne Tatha ) is a firth in Scotland between the council areas of Fife, Perth and Kinross, the City of Dundee and Angus, into which Scotland's largest river in terms of flow, the River Tay empties.

The poem places his death by the River Tay, though this is not necessarily a contradiction to other accounts of his death ( which place it by river Almond ).

* Perth is a small but historic city on the east coast, which stands on the River Tay.