Dihydrobiopterin Reductase activity is to replenish quinonoid-Dihydrobiopterin back into its Tetrahydrobiopterin form, which is an important cofactor in many metabolic reactions in amino acid metabolism.

Those with this deficiency may produce sufficient levels of Phenylalanine Hydroxylase, but since Tetrahydrobiopterin is a cofactor for Phenylalanine Hydroxylase activity, deficient Dihydrobiopterin Reductase renders any Phenylalanine Hydroxylase enzyme produced unable to use Phenylalanine to produce Tyorosine.

Tetrahydrobiopterin is required to convert phenylalanine to tyrosine, but it is also required to convert tyrosine to L-DOPA ( via the enzyme tyrosine hydroxylase ), which in turn is converted to dopamine.

Tetrahydrobiopterin provides an additional electron during the catalytic cycle which is replaced during turnover.

Tetrahydrobiopterin deficiency can be caused by defects in four different genes.

It is also possible, but equally doubtful, that he actually shot down the hundreds of men with which his legend credits him.

Recognizing that the Rule of Law is `` a dynamic concept which should be employed not only to safeguard the civil and political rights of the individual in a free society '', the Congress asserted that it also included the responsibility `` to establish social, economic, educational and cultural conditions under which his legitimate aspirations and dignity may be realized ''.

At General Power's seat in the balcony there is also a gold phone.

In addition to the authentication and acknowledgment procedures which precede and follow the sending of the go messages, again in special codes, each message also contains an `` internal authenticator '', another specific signal to convince the recipient that he is getting the real thing.

He added that he also stresses the works of these favorite masters on tour, especially Mahler's First and Fourth symphonies, and Das Lied Von der Erde, and Bruckner's Sixth -- which is rarely played -- and Seventh.

The test of form is fidelity to the experience, a gauge also accepted by the abstract expressionist painters.

Though he is also concerned with freeing dance from pedestrian modes of activity, Merce Cunningham has selected a very different method for achieving his aim.

The answers derived by these means may determine not only the temporal organization of the dance but also its spatial design, special slips designating the location on the stage where the movement is to be performed.

It is because there is not only darkness but also light that our situation becomes inexplicable.

but there is also compassion.

also he is a drunk, and has lost his job on that account.

And if I have gone into so much detail about so small a work, that is because it is also so typical a work, representing the germinal form of a conflict which remains essential in Mann's writing: the crude sketch of Piepsam contains, in its critical, destructive and self-destructive tendencies, much that is enlarged and illuminated in the figures of, for instance, Naphta and Leverkuhn.

By `` image '' is meant not only a visual presentation, but also remembered sensations of any of the five senses plus the feelings which are immediately conjoined therewith.

he is questioning, also, every epistemology which stems from Hume's presupposition that experience is merely sense data in abstraction from causal efficacy, and that causal efficacy is something intellectually imputed to the world, not directly perceived.

it is true that they are also extremely dull.

Now the detective must save his own skin by informing on the girl he loves, who is also the real murderer.

But it is also the climax to one of the absorbing chapters in our current political history.

Since a civilizational crisis involves also a crisis in private interests and in the ruling class, reaction is normally found among those who feel themselves to be among the ruling class.

`` The Rocking Horse Winner '' is also a story about a boy's love for his mother.

Evidence is plentiful that early and later also he has been indebted to the Gothic romancers, who deal in extravagant horror, to the symbolists writing at the end of the preceding century, and in particular to the stream-of-consciousness novelists, Henry James and James Joyce among them.

A rarer form of hyperphenylalaninemia occurs when PAH is normal, but there is a defect in the biosynthesis or recycling of the cofactor tetrahydrobiopterin ( BH < sub > 4 </ sub >) by the patient.

This cofactor is necessary for proper activity of the enzyme.

In the synthesis of collagen, ascorbic acid is required as a cofactor for prolyl hydroxylase and lysyl hydroxylase.

For solvable groups, Hall's theorems assert the existence of a subgroup of order equal to any unitary divisor of the group order ( that is, a divisor coprime to its cofactor ).

-DOPA is converted into dopamine by the enzyme aromatic-amino acid decarboxylase ( AAAD ; also known as DOPA decarboxylase ( DDC )) with pyridoxal phosphate ( PLP ) as the cofactor.

Finally, norepinephrine is converted into epinephrine by the enzyme phenylethanolamine N-methyltransferase ( PNMT ) with S-adenosyl -- methionine ( SAMe ) as the cofactor.

There is an increasing trend of using ICP-MS as a tool in speciation analysis, which normally involves a front end chromatograph separation and an elemental selective detector, such as AAS and ICP-MS. For example, ICP-MS may be combined with size exclusion chromatography and quantitative preparative native continuous polyacrylamide gel electrophoresis ( QPNC-PAGE ) for identifying and quantifying native metal cofactor containing proteins in biofluids.

Several forms of the vitamin are known, but pyridoxal phosphate ( PLP ) is the active form and is a cofactor in many reactions of amino acid metabolism, including transamination, deamination, and decarboxylation.

Pyridoxal phosphate ( PLP ) is a cofactor in transaminases that can catabolize amino acids.

PLP is also an essential cofactor for enzymes involved in the metabolism of selenomethionine to selenohomocysteine and then from selenohomocysteine to hydrogen selenide.

Pyridoxal phosphate is needed as a cofactor for the enzymes that allow selenium to be used from the dietary form.

Two of them are subunits of hexosaminidase A ; the third is a small glycolipid transport protein, the GM2 activator protein ( GM2A ), which acts as a substrate-specific cofactor for the enzyme.

Copper is needed by the body for a number of functions, predominantly as a cofactor for a number of enzymes such as ceruloplasmin, cytochrome c oxidase, dopamine β-hydroxylase, superoxide dismutase and tyrosinase.

In mammals this is a redox ( reduction / oxidation ) reaction involving the coenzyme nicotinamide adenine dinucleotide ( NAD < sup >+</ sup >) and cofactor PQQ.

The holoprotein ( protein + heme cofactor ) is widely believed to be a product of both plant and the bacterium in which the apoprotein is produced by the plant and the heme ( an iron atom bound in a porphyrin ring ) is produced by the bacterium.

Lys-680 is involved in binding the pyridoxal phosphate, which is the active form of vitamin B < sub > 6 </ sub >, a cofactor required by myophosphorylase.