According to the Bible, God commanded Abraham in the Binding of Isaac to sacrifice his son, but ultimately provided a ram as a substitute.

Isaac embraces his father Abraham after the Binding of Isaac, early 1900s Bible illustration

According to the traditional counting cited by Rashi, Isaac was 37 years old at the time of the Binding of Isaac, and news of Rebekah's birth reached Abraham immediately after that event.

Binding of Isaac | The Sacrifice of Isaac by Caravaggio, ( 1590 – 1610 ; Oil on canvas ; Uffizi ).

* Binding of Isaac

* Judas, a character in The Binding of Isaac

Jewish tradition names it as the location for a number of important events which occurred in the Bible, including the Binding of Isaac, Jacob's dream, and the prayer of Isaac and Rebekah.

In the indie videogame The Binding of Isaac, the Book of Shadows is an obtainable item which can be activated to provide temporary invincibility.

* Binding of Isaac

* In the popular Indie Game The Binding of Isaac, all of the Major Arcana / Minor Arcana Tarot cards can be found and used during gameplay.

* In the popular Indie Game The Binding of Isaac, all of the Major Arcana / Minor Arcana Tarot cards can be found and used during gameplay.

* In the popular Indie Game The Binding of Isaac, all of the Major Arcana / Minor Arcana Tarot cards can be found and used during gameplay.

* In the popular Indie Game The Binding of Isaac, all of the Major Arcana / Minor Arcana Tarot cards can be found and used during gameplay.

* In the popular Indie Game The Binding of Isaac, all of the Major Arcana / Minor Arcana Tarot cards can be found and used during gameplay.

In The Binding of Isaac, Religious Murders & Kabbalah, Lippman Bodoff argues that Abraham never intended to actually sacrifice his son, and that he had faith that God had no intention that he do so.

In The Guide for the Perplexed, Maimonides argues that the story of the Binding of Isaac contains two " great notions.

As her study demonstrates, over the last century the " Binding of Isaac " has morphed into the " Sacrifice of Isaac ," connoting both the glory and agony of heroic death on the battlefield.

In Glory and Agony: Isaac's Sacrifice and National Narrative, Yael S. Feldman argues that the story of Isaac's Binding, in both its biblical and post-biblical versions ( the New Testament included ) has had a great impact on the ethos of altruist heroism and self-sacrifice in modern Hebrew national culture.

In Mimesis: The Representation of Reality in Western Literature, the literary critic Erich Auerbach considers the Hebrew narrative of the Binding of Isaac, along with Homer's description of Odysseus's scar, as the two paradigmatic models for the representation of reality in literature.

* Akeidah ( עקידה ) — Hebrew for " binding ", a word which specifically refers to the Binding of Isaac.

Binding of this receptor can also indirectly lead to the activation of transcription factors involved in cell survival and inflammatory responses.

Binding of cardiac glycoside to Na-K ATPase is slow, and also, after binding, intracellular calcium increases gradually.

Although earlier BBC radio shows such as Much Binding in the Marsh, Take It From Here and Beyond Our Ken had conditioned listeners to a mix of music, sketches and jokes within a 30 minute show, and Round the Horne was also doing this, ISIRTA ( as it was known to its friends ) accelerated the transitions, and it certainly seemed more improvised.

Binding of serum from a patient with Morvan ’ s Syndrome to the hippocampus in a similar pattern of antibodies to known VGKC suggest that these antibodies can also cause CNS dysfunction.

The binding phenomena found in natural languages was particularly important to the syntactic government and binding theory ( see also: Binding ( linguistics )).

The Binding of Isaac is mentioned in the New Testament Epistle to the Hebrews among many acts of faith recorded in the Old Testament: By faith Abraham, when he was tested, offered up Isaac, and he who had received the promises offered up his only begotten son, of whom it was said, " In Isaac your seed shall be called ," concluding that God was able to raise him up, even from the dead, from which he also received him in a figurative sense.

The Binding also figures prominently in the writings of several of the more important modern theologians, such as Søren Kierkegaard in Fear and Trembling and Shalom Spiegel in The Last Trial.

Binding of ligand can be characterised using a variety of analytical techniques such as surface plasmon resonance, microscale thermophoresis or dual polarisation interferometry to quantify the reaction affinities and kinetic properties and also any induced conformational change.

Binding of RNA polymerase to the promoter is aided by the cAMP-bound catabolite activator protein ( CAP, also known as the cAMP receptor protein ).

Binding sites also exist on antibodies as specifically coded regions that bind antigens based upon their structure.

Binding sites also exhibit chemical specificity, a measure of the types of ligands that will bond, and affinity, which is a measure of the strength of the chemical bond.

The beer is now filled at the Binding Brauerei also in Frankfurt.

Principles and Parameters as a grammar framework is also known as Government and Binding theory.

Binding goes on to assume that the right to suicide would then also have to be transferable to another person ; meaning that a person also has the right to let someone else cause their death if they so wish.

Binding also wanted to allow for killings that were not controlled by a committee.

* TATA Binding Protein, commonly known as TBP, involved in the binding of polymerases to DNA to allow transcription

The Forest Principles is the informal name given to the " Non-Legally Binding Authoritative Statement of Principles for a Global Consensus on the Management, Conservation and Sustainable Development of All Types of Forests ," a document produced at the 1992 United Nations Conference on Environment and Development ( UNCED ), informally known as the Earth Summit.

Indeed, the purpose of recounting the near sacrifice of Isaac, known in Judaism as " The Binding of Isaac " ( Akeidat Yitzhak or the Akeidah ) was to illustrate the sublime significance and need of animal sacrifices as supplanting the abomination of human sacrifices.

Karl Ludwig Lorenz Binding ( April 6, 1841 – April 7, 1920 ) was a German jurist known as a promoter of the theory of retributive justice.

Binding of molecules uniquely found in microbes — viral glycoproteins, viral RNA, bacterial endotoxin ( lipopolysaccharide ), bacterial flagella, CpG motifs -- by pattern recognition receptors, such as membrane bound Toll like receptors or the cytoplasmic receptors RIG-I or MDA5, can trigger release of IFNs.

:* E Complex-U1 binds to the GU sequence at the 5 ' splice site, along with accessory proteins / enzymes ASF / SF2, U2AF ( binds at the Py-AG site ), SF1 / BBP ( BBP = Branch Binding Protein );

* Binding ( linguistics ), a property relating to anaphors ( and pronouns and R-expressions ) and c-command

* Binding ( knot ), a type of knot

* Binding ( sewing ), a finish to a seam or hem

* Surname of Karl Binding ( 1841 – 1920 ), German jurist

The distinction between lexical and functional categories plays a big role in Chomskyan grammars ( Transformational Grammar, Government and Binding Theory, Minimalist Program ), where the role of the functional categories is large.

* PRO ( linguistics ), an empty category whose existence is postulated in classical Government and Binding Theory

* Regemorter, Berthe van, Binding Structures in the Middle Ages, ( translated by J. Greenfield ), 1992, Bibliotheca Wittockiana, Brussels

* Tim Binding ( born 1947 ), novelist

* Binding sites for proteins, that may affect the mRNA's stability or location in the cell, like SECIS elements ( which direct the ribosome to translate the codon UGA as selenocysteines rather than as a stop codon ), or AU-rich elements ( AREs ), stretches consisting of mainly adenine and uracil nucleotides ( which can either stabilize or destabilize the mRNA depending on the protein bound to it ).

Water Structure and Ion Binding: A Role in Cell Physiology, Science, 192 ( 4254 ), June 18, 1976, pp. 1220-1222.

* Bills, Emily, " Connecting Lines: L. A .' s Telephone History and the Binding of the Region ", Southern California Quarterly, 91 ( Spring 2009 ), 27 – 67.

* Java Architecture for XML Binding ( JAXB ), v 1. 0 and 2. 0

Maimonides deals with the problem of evil ( for which people are considered to be responsible because of free will ), trials and tests ( especially those of Job and the story of the Binding of Isaac ) as well as other aspects traditionally attached to God in theology, such as providence and omniscience: " Maimonides endeavors to show that evil has no positive existence, but is a privation of a certain capacity and does not proceed from God ; when, therefore, evils are mentioned in Scripture as sent by God, the Scriptural expressions must be explained allegorically.

Much work in Government and Binding Theory ( GB ), the Minimalist Program ( MP ), and Lexical Functional Grammar ( LFG ) takes all branching to be binary.

Smith, Y. Jiang, Finding Motifs for Insufficient Number of Sequences with Strong Binding to Transcription Factor, Proceedings of the 8th Annual International Conference on Research in Computational Molecular Biology ( RECOMB 2004 ), Westin Hotel Horton Plaza, San Diego, CA USA, March 2004

and either ( a ) reduces them to more fundamental principles ( e. g. Merge, Move, Agree ), ( b ) derives them from ` reasonable ’ interface constraints on derivations ( e. g. bottom-up Merge and requirement that no derivation be counter-cyclic derives Relativized Minimality effects ) or ( c ) programmatically suggests that they be either derived from more basic principles or eliminated subject to future research ( e. g. Binding Principles ).

The cultic ancient name of the area was ( w -) pkr or ( r3 -) pkr ' District of the poker-tree ( unidentified species ' or ' Opening of the poker-tree '( Coptic: upoke ), belonging to t3-dsr ' the secluded / cleared land '(= necropolis ) or crk-hh ' Binding of Eternity '( Coptic Alkhah.

General Binding Corporation ( GBC ), in the business of packaging and presenting information for more than a half century, is among the world leaders in binding, laminating, and displaying products.