Antipsychotics are among the biggest selling and most profitable of all drugs, generating $ 22 billion in global sales in 2008.

Just outside Paris, France, the Fontainebleau area is the biggest and most developed bouldering area in the world.

Despite fox hunting being banned by the Hunting Act in 2004, Boxing Day remains the biggest hunt of the year for most hunts in the UK by use of scent drag trails instead of live quarry.

There was a vast amount of publicity around the film, with a critic for the New York Times calling it " the most eagerly awaited picture of the year ", and it was one of the biggest money-makers of the era.

It was most likely politics which had the biggest impact in leading to a delay of almost three decades before the second commercial channel became a reality.

* Chaos Computer Club, one of the biggest and most influential hacker organisations

* Little Miss Marker ( 1934 )— The film that made Shirley Temple a star, launched her career as perhaps America's most beloved child film star, and pushed her past Greta Garbo as the nation's biggest film draw of the year.

In spite of the closure of most of France's tram systems in earlier years, a fast growing number of France's major cities have modern tram or light rail networks, including Paris, Lyon ( Lyon having the biggest one ), Toulouse, Montpellier, Saint-Étienne, Strasbourg and Nantes.

He traded most of the club's best players in one of the biggest fire sales in sports history.

Peaceful collaborations with its neighbors remain one of Germany's biggest political objectives, and Germany has been on the forefront of most achievements made in European integration:

New World's biggest change was in adding around ten minutes of new footage, most of it at The Pentagon, with Raymond Burr reprising his role as Steve Martin from Godzilla, King of the Monsters !.

In 1938 Gdynia was the largest and most modern seaport on the Baltic Sea, as well as the tenth biggest in Europe.

The resulting Italian diaspora concerned nearly 25 million Italians, the most part emigrated in the period 1880-1914, and it is considered the biggest mass migration of contemporary times.

Named after King Amanullah Khan, it is said to be the first, the biggest and the most modern city in the history of Afghanistan.

Rolling Stone magazine described them as " the heaviest band of all time ", " the biggest band of the ' 70s " and " unquestionably one of the most enduring bands in rock history ".

The Cannes Film Festival Ecumenical Jury, which gives prizes for movies that promote spiritual, humanist and universal values, also " honoured " the film with a special " anti-award "; a spokesman for the jury described it as " the most misogynist movie from the self-proclaimed biggest director in the world.

The VAZ factory is one of the biggest in the world, with over of production lines, and is unique in that most of the components for the cars are made in-house.

The most successful musical of the 1960s created specifically for film was Mary Poppins, one of Disney's biggest hits.

As June came to a close, the Brewers made their biggest move for playoff contention as they traded 4 prospects, most notably Matt LaPorta, to the Cleveland Indians for CC Sabathia.

Harvey A. Silverglate, a prominent defense attorney who represented Milken during the appellate process, disputes that view in his book Three Felonies a Day: “ Milken ’ s biggest problem was that some of his most ingenious but entirely lawful maneuvers were viewed, by those who initially did not understand them, as felonious, precisely because they were novel – and often extremely profitable .”

The two biggest and most important Hindu festivals — Dashain and Tihar ( Dipawali )— arrive during this period, about one month apart.

* The Ichi-Lineage today comprises most of the traditional schools within Nichiren Buddhism, including some Nikkō temples, of which the Nichiren Shū is the biggest representative.

Adam Mickiewicz University ( abbreviated UAM in Polish, AMU in English ) is one of the most influential and biggest universities in Poland:

As well as the stations and other facilities and attractions already mentioned, in the immediate area was one of the world ’ s biggest and most luxurious department stores: Wertheim, also mentioned earlier.

The year 2010 is considered an important year for Dutch hip-hop, with many albums and mixtapes released from the biggest Dutch rappers.

Control of trade, the flow of resources and prestige goods, became ever more important to the elites of Southern Britain ; as the provider of relatively limitless wealth and patronage, Rome steadily became the biggest player in all their dealings.

Although this also used the Latin alphabet, it was much less affected by the ban, because Polish was still used by the politically important class of the nobility, and also used predominantly in the biggest towns of Lithuania, and supported by the church.

Doll Revolution was a solid comeback success in Germany after the Bangles had performed in Germany's biggest television show Wetten dass, but failed to make any impact in other important markets such as the UK, the U. S. and Australia.

The town is home to one of the ' Ndrangheta's biggest and most important clans, the Commisso ' ndrina, heavily involved in the global cocaine business and money laundering.

Haley and His Comets then recorded " Rock Around the Clock ", Haley's biggest hit, and one of the most important records in rock and roll history.

In the 20 years between the world wars, Grudziądz served as an important centre of culture and education with one of the biggest Polish military garrisons and several military schools located both in and around the city.

They are one of the biggest and most important collection of royal objects still today, and reflect more than a thousand years of European history.

He cites Béla Bartók, Igor Stravinsky, Pérotin, Léonin, Claude Debussy and Organum musical style as important influences, but what made the biggest impact on his compositions was the serialism of Arnold Schoenberg and Anton Webern.

With the world's biggest inland harbour and its proximity to Düsseldorf International Airport, Duisburg has become an important venue for commerce and steel production.

A few other important buildings in the city are the Amphion-Theater, the Gruitpoort, a big cultural centre, the Rietveld Lyceum, the biggest high school in Doetinchem and the Tax administration office.

The Jordans were featured on several Alan Freed stage shows and were mainstays on all the important East Coast TV programs, especially in the Tri-State area. Their biggest hit, in 1966, was " Gimme Some Lovin.

For the past 1, 000 years it has been home to some of the biggest markets in the country, and in the thirteenth century it was an important entrepôt, and remains an important market in East Anglia.

Tourism is an important industry, worth over annually, with by far the most significant draw being the annual Tamworth Country Music Festival, the biggest event of its type in Australia and the Southern Hemisphere.

making it the second biggest in the province and an important regional center, conveniently located roughly halfway between Liège and the German border.

The important occupations in Sunndal include industry ( with Hydro Aluminium Sunndal as the biggest employer ), public services, retail, and farming.

The Appalachian Basin is one of the most important coal producing regions in the US and one of the biggest in the world.

The one-time biggest stadium in the world was the home of Botafogo in many important games in Rio de Janeiro since then.

In the last few years, the State Government promoted the total restoration of the Pelourinho, the biggest set of colonial style buildings in Latin America, today transformed into an important point for visitation by tourists, that will find there a synthesis of what best Bahia has to offer in specialized services, in regional and international cooking, in architecture of the 17th and 18th centuries and in music, with daily shows by the great artists of Bahia, famous in the country and abroad.

The company is also active in Hungary, where it is the biggest publisher of regional newspapers, and in Poland, where it owns the best-selling tabloid Fakt, one of the nation's most important broadsheets, Dziennik, and is one of the biggest shareholder in # 2 private TV company, Polsat.

By this time there were many other important contributors, but one should not omit to mention Geoff Whittle's extension to ternary matroids of Tutte's characterization of binary matroids that are representable over the rationals, perhaps the biggest single contribution of the 1990s.