Chymotrypsin is a digestive enzyme component of pancreatic juice acting in the duodenum where it performs the breakdown of proteins and polypeptides proteolysis.

In these milder cases, there is still sufficient pancreatic exocrine function so that enzyme supplementation is not required.

Targets for therapy are the lungs, gastrointestinal tract ( including pancreatic enzyme supplements ), the reproductive organs ( including assisted reproductive technology ( ART )) and psychological support.

Human pancreatic enzyme activity is reduced when incubated with most fiber sources.

The dispersion of food fat into micelles thus provide a largely increased surface area for the action of the enzyme pancreatic lipase, which actually digests the triglycerides, and is able to reach the fatty core through gaps between the bile salts.

While the outcome of trials regarding pain reduction with pancreatic enzyme replacement is inconclusive, some patients do have pain reduction with enzyme replacement and since they are relatively safe, giving enzyme replacement to a chronic pancreatitis patient is an acceptable step in treatment for most patients.

It is interesting to note that secretin also inhibits production of gastrin by " G cells ", and also stimulates acinar cells of the pancreas to produce their pancreatic enzyme.

For example, whereas the pancreatic estrase is selective for short-chain retinyl esters, the brush-border membrane enzyme preferentially hydrolyzes retinyl esters containing a long-chain fatty acid such as palmitate or stearate.

Trypsinogen ( EC 3. 4. 23. 18 / 20 / 21 / 23 / 24 / 26 ) is the precursor form or zymogen of the pancreatic enzyme trypsin.

For example, if the bacterial overgrowth is caused by chronic pancreatitis, the patient should be treated with coated pancreatic enzyme supplements.

Pancrelipase is a form of enzyme therapy for the treatment of various digestive disorders, primarily exocrine pancreatic insufficiency.

Pancreatic lipase, also known as pancreatic triacylglycerol lipase, is secreted from the pancreas, and is the primary lipase ( enzyme ) that hydrolyzes ( breaks down ) dietary fat molecules in the human digestive system, converting triglyceride substrates found in ingested oils to monoglycerides and free fatty acids.

Carboxypeptidase, which is a digestive enzyme present in pancreatic juice, will cleave a single amino acid from the carboxylic end of the peptide.

Its function is to complete the process begun by pancreatic juice ; the enzyme trypsin exists in pancreatic juice in the inactive form trypsinogen, it is activated by the intestinal enterokinase in intestinal juice.

In the most extreme cases, these patients will produce no pancreatic lipase, yet even when the enzyme is completely absent, dietary fat is still absorbed.

It has, thus, been proposed that a possible treatment option for exocrine pancreatic insufficiency would be enzyme replacement therapy using lingual lipase, increasing the amount of dietary fat absorption and decreasing the risk of malnutrition.

While there are many means of achieving this, two of the most common are prolonged boiling in a strong acid ( acid-HVP ) or strong base or using an enzyme such as the pancreatic protease enzyme to stimulate the naturally occurring hydrolytic process.

The adipocyte, or fat cell, is designed for continuous synthesis and breakdown of triglycerides in animals, with breakdown controlled mainly by the activation of hormone-sensitive enzyme lipase.

The active enzyme in rennet is called chymosin or rennin () but there are also other important enzymes in it, e. g., pepsin and lipase.

An additional enzyme, lingual lipase, hydrolyzes long-chain triglycerides into partial glycerides and free fatty acids.

Xanthines such as caffeine, theobromine, and thyroid hormone are phosphodiesterase inhibitors ( enhance lipolysis as inhibition of phosphodiesterase enzyme, thereby preserving cAMP, also activating kinase enzyme, which phosphorylates hormone-sensitive lipase and activates lipolysis ).

* Lipid catabolism is decreased due to lower levels of lipoprotein lipase, the main enzyme involved in lipoprotein breakdown.

An acid hydrolase ( lysosomal acid lipase ) is an enzyme that works best at acidic pHs.

* Lipoprotein lipase deficiency-Deficiency of this water soluble enzyme, that hydrolyzes triglycerides in lipoproteins, leads to elevated levels of triglycerides in the blood.

In Provolone Piccante, the distinctive piquant taste is produced with lipase ( enzyme ) derived from goat.

The triglycerides in VLDL are removed in capillaries by the enzyme lipoprotein lipase, and the VLDL returns to the circulation as a smaller particle with a new name, intermediate-density lipoprotein ( IDL ).

It was found that breakdown of a lipid product of PLC cascade, diacylglycerol ( DAG ), by the enzyme Diacylglycerol lipase, generates PUFAs that can activate TRP channels thus initiating membrane depolarization in response to light.

Triglycerides are emulsified by bile and hydrolyzed by the enzyme lipase, resulting in a mixture of fatty acids and monoglycerides.

The crystal structure of LPL has not been discovered ; however, there are substantial experimental evidence and structural homology between members of the lipase family to predict the likely structure and functional regions of the enzyme.

It has long been held that hormone-sensitive lipase ( HSL ) is the enzyme that hydrolyses triacylglycerides to free fatty acids from fats ( lipolysis ).

Creon 10, 000 mini-microspeheres ( delayed release capsules ) is available in China, Singapore, Malaysia and Thailand with enzyme contains lipase 10, 000 u, amylase 8, 000 u, protease 600 u.

Zymase is also the brand name of the generic enzyme mixture pancrelipase, a dietary supplement containing the enzymes amylase, peptidase, and lipase.

* They are enzyme coenzymes ( C-II for lipoprotein lipase and A-I for lecithin-cholesterol acyltransferase )

This fact, in combination with the bile salt deficiency and low pH throughout the gastrointestinal tract of the neonate, demands that lingual lipase be the main enzyme catalyzing the hydrolysis of dietary fat.

Ampicillin acts as a competitive inhibitor of the enzyme transpeptidase, which is needed by bacteria to make their cell walls.

In such situations, the kidneys release renin, which acts as an enzyme and cuts off all but the first 10 amino acid residues of angiotensinogen ( a protein made in the liver, and which circulates in the blood ).

He studied norepinephrine, which acts on the liver to convert glycogen into glucose via the activation of the phosphorylase enzyme.

* Stains produced by the yeast Monascus purpureus is commercialised as blood cholesterol lowering agents which acts by competitively inhibiting the enzyme responsible for synthesis of cholesterol.

One recognition site acts as the target for cleavage, while the other acts as an allosteric effector that speeds up or improves the efficiency of enzyme cleavage.

In many cases the assembly is not uniquely specified ; depending on which enzyme acts, one of several different units may be incorporated.

Phenytoin acts by inhibiting this enzyme, thereby causing folate deficiency.

Renin is secreted from granules in the JG cells, and once in the blood stream, it acts as a protease to convert angiotensinogen to angiotensin I, which is converted by angiotensin converting enzyme, to angiotensin II, which, in turn, stimulates aldosterone release.

Two of them are subunits of hexosaminidase A ; the third is a small glycolipid transport protein, the GM2 activator protein ( GM2A ), which acts as a substrate-specific cofactor for the enzyme.

It acts as a very weak, non-selective and reversible inhibitor of the enzyme monoamine oxidase ( MAO ), but this is unlikely to be very significant if at all with typical doses.

The enzyme acts as an amplifier ; even if only few enzyme-linked antibodies remain bound, the enzyme molecules will produce many signal molecules.

Mycophenolic acid acts as a non-competitive, selective, and reversible inhibitor of Inosine-5 ′- monophosphate dehydrogenase ( IMPDH ), which is a key enzyme in the de novo guanosine nucleotide synthesis.

Some epidemiological and in vitro studies suggest the hemolysis resulting from favism acts as protection from malaria, because certain species of malarial protozoa, such as Plasmodium falciparum, are very sensitive to oxidative damage due to deficiency of the glucose 6-phosphate dehydrogenase enzyme, which would otherwise protect from oxidative damage via production of glutathione reductase.

Tranylcypromine ( Parnate, Jatrosom ) is a drug of the substituted phenethylamine and amphetamine classes which acts as a monoamine oxidase inhibitor ( MAOI )— it is a nonselective and irreversible inhibitor of the enzyme monoamine oxidase ( MAO ).

ALDH2, which has a lower K < sub > M </ sub > for acetaldhehydes than ALDH1 and acts predominantly in the mitochondrial matrix, is the main enzyme in acetaldehyde metabolism and has three genotypes.

In short, Rho factor acts as an ATP-dependent unwinding enzyme, moving along the newly forming RNA molecule towards its 3 ' end and unwinding it from the DNA template as it proceeds.

*: RNase P is a type of ribonuclease that is unique in that it is a ribozyme – a ribonucleic acid that acts as a catalyst in the same way as an enzyme.

This allows proteins to quickly find the correct arrangement of disulfide bonds in their fully folded state, and therefore the enzyme acts to catalyze protein folding.

In biochemistry, a substrate is a molecule upon which an enzyme acts.

Glu35 acts as a proton donor to the glycosidic bond, cleaving the C-O bond in the substrate, whereas Asp52 acts as a nucleophile to generate a glycosyl enzyme intermediate.

The enzyme acts on the fatty acid glucosylceramide.