Known causes of premature ovarian failure include autoimmune disorders, thyroid disease, diabetes mellitus, chemotherapy, being a carrier of the fragile X syndrome gene, and radiotherapy.

Fragile X syndrome is associated with the expansion of the CGG trinucleotide repeat affecting the Fragile X mental retardation 1 ( FMR1 ) gene on the X chromosome, resulting in a failure to express the fragile X mental retardation protein ( FMRP ), which is required for normal neural development.

Depending on the length of the CGG repeat, an allele may be classified as normal ( unaffected by the syndrome ), a premutation ( at risk of fragile X associated disorders ), or full mutation ( usually affected by the syndrome ).

A definitive diagnosis of fragile X syndrome is made through genetic testing to determine the number of CGG repeats.

There is currently no drug treatment that has shown benefit specifically for fragile X syndrome.

Supportive management is important in optimizing functioning in individuals with fragile X syndrome, and may involve speech therapy, occupational therapy, and individualized educational and behavioral programs.

Some individuals with fragile X syndrome also meet the diagnostic criteria for autism.

Children with fragile X have very short attention spans, are hyperactive, and show hypersensitivity to visual, auditory, tactile, and olfactory stimuli.

About 20 % of women who are carriers for the fragile X premutation are affected by fragile X-related primary ovarian insufficiency ( FXPOI ), which is defined as menopause before the age of 40.

Fragile X syndrome is a genetic disorder which occurs as a result of a mutation of the fragile X mental retardation 1 ( FMR1 ) gene on the X chromosome, most commonly an increase in the number of CGG trinucleotide repeats in the 5 ' untranslated region of FMR1.

Individuals with fragile X syndrome have a full mutation of the FMR1 allele, with over 200 repeats of the CGG codon.

In these individuals with a repeat expansion greater than 200, there is methylation of the CGG repeat expansion and FMR1 promoter, leading to the silencing of the FMR1 gene and a lack of its product, fragile X mental retardation protein ( FMRP ).

This methylation of FMR1 in chromosome band Xq27. 3 is believed to result in constriction of the X chromosome which appears ' fragile ' under the microscope at that point, a phenomenon that gave the syndrome its name.

Cytogenetic analysis for fragile X syndrome was first available in the late 1970s when diagnosis of the syndrome and carrier status could be determined by culturing cells in a folate deficient medium and then assessing for " fragile sites " ( discontinuity of staining in the region of the trinucleotide repeat ) on the long arm of the X chromosome.

By determining the number of CGG repeats on the X chromosome, this method allows for more accurate assessment of risk for premutation carriers in terms of their own risk of fragile X associated syndromes, as well as their risk of having affected children.

The hymen is, in essence, a fragile membrane that more or less completely covers the entrance to the vagina in most female human beings who have not had sex relations.

Often it is thin and fragile and gives way readily to the male organ at the first attempt at intercourse.

Chabrier's little one-act operetta, presented yesterday afternoon at Town Hall, is a fragile, precious little piece, very French, not without wit and charm.

But what is equally impressive is the delicacy and wonderful lyric quality of both the band and Mulligan's baritone sax in a fragile ballad like Bob Brookmeyer's arrangement of `` Django's Castle ''.

An example of X-linked ataxic condition is the rare fragile X-associated tremor / ataxia syndrome.

As its condition is fragile and it is a prized exhibit at the MCC Cricket Museum, the MCC were reluctant to agree.

Shaping Edwin ’ s ambitious journey in the world of the theater is his love of three women: the beautiful, strong-minded Julia Scarlet, whom he first meets in Ann Arbor ; the emotionally fragile and haunting Jessamy Lee, and the very private and mysterious leading lady Adelina Kane, idol of the American stage.

Feral pigs, foxes, cats and rabbits are also imported animals that degrade the environment, so time and money is spent eradicating them in an attempt to help protect fragile rangelands.

At present, such areas comprise about 30, 000 km², and several are in countries where political stability is fragile.

The CRT uses an evacuated glass envelope which is large, deep ( i. e. long from front screen face to rear end ), fairly heavy, and relatively fragile.

In the novel Man Plus by Frederick Pohl, an able-bodied astronaut, Roger Torraway, is surgically altered in order to augment his fragile human body and allow him to function in the harsh climate of Mars.

Some contemporary bluegrass bands favor the electric bass, because it is easier to transport than the large and somewhat fragile upright bass.

The specimen is returned to room temperature and pressure, then the extremely fragile " pre-shadowed " metal replica of the fracture surface is released from the underlying biological material by careful chemical digestion with acids, hypochlorite solution or SDS detergent.

This trophy still exists but is now too fragile to be used, so an exact replica was made by Toye, Kenning and Spencer and has been in use since the 1992 final.

Other areas of the Gulf Coast have benefited less, though economic development fueled by tourism has greatly increased property values along the coast, and is now a severe danger to the valuable but fragile ecosystems of the Gulf Coast.

The problem is that disks are very fragile, and mergers with other galaxies can quickly destroy thin disks.

The hoof capsule is mostly made from keratin, a protein, and is weakened by this exposure, becoming even more fragile and soft.

The Mage uses an assortment of long-range spells, whose reach is counterbalanced by the fact that he is the most fragile and slowest moving of the classes.

# The tiny fragile electrical wiring is physically supported and protected from damage.

The problem recognized by the international community is that this unique and valuable land has proven fragile.

However, the new geopolitical logic of the Cold War made possible that the former enemy Italy, a hinge-country between Western Europe and the Mediterranean, and now a new, fragile democracy threatened by the proximity of the Iron Curtain and the presence of a strong Communist party, was considered by the USA as an important ally for the Free World, and received under the Marshall Plan US $ 1, 204 million from 1947 to 1951.

Since the gels are fragile and the probes are unable to enter the matrix, the RNA samples, now separated by size, are transferred to a nylon membrane through a capillary or vacuum blotting system.

Historically some works have been executed on supports which are now extremely fragile and the support rather than the pigment needs to be protected under glass and away from light

The age pyramid now looks more like a ' mushroom ' resting on a fragile base.

Astronauts returning from space missions also commented on how fragile the Earth looked from space, further fueling calls for better stewardship of the only home humans have — for now.

Sukarno's fragile balance of power between the military, political Islam, communists, and nationalists that underlay his " Guided Democracy " was now collapsing.

The rest are still tablets of unfired clay, and extremely fragile ; some modern scholars are investigating the possibility of firing them now, as an aid to preservation.

It is now in a fragile state after much mistreatment.

The National Archives has also now set up a ' digitisation on demand ' service ( called ' Digital Express ') where for a small fee a document can be scanned and sent to the researcher electronically ( up to 10 pages for a fixed fee ) to enable people to access the documents wherever they are, ( excluding particularly large or fragile records ).

A direct result of this is the release of the film " Super Dimension Fortress Macross: Do You Remember Love " in 2031 to remind the masses of the fragile peace they now enjoy with themes like the near extinction of humanity and some of the momentous events leading up to the end of War with the Zentradi and ending with ' Actual ' footage of Minmay's Goodbye Concert Tour.

Officials at the Reina Sofía claim that the huge canvas is now thought to be too fragile to move.

The author of great epics, being already blind, alters his view into something vital and worthy of interest – no more battle ’ s clamor, but now detail, something which is considered to be the most personal and fragile.

The Friends of High Salvington Mill have had to rebuild the head wheel, but the tail wheel, an original of a rare " compass arm " design, is now too fragile to be used for grinding.

Pantographs with overhead wires are now the dominant form of current collection for modern electric trains because, although more expensive and fragile than a third-rail system, they allow the use of higher voltages.

Jack's marriage to Ann was also arguably a huge turning point in the two brothers ' fragile relationship as well ; Harry's arguments with Jack were now practically on a daily basis.

The brothers ' fragile relationship was now worsening even more.

The Times wrote: " To the long list of things the Bush administration is willing to trash in its rush to appease immigration hard-liners, you can now add dozens of important environmental laws and hundreds of thousands of acres of fragile habitat on the southern border.

Towards the end of 1979, 25 soldiers were to play a significant role during Operation Agila, which monitored the fragile ceasefire in Rhodesia ( now Zimbabwe ) prior to and during the first all-party elections.

; May 5: Companys obtains a fragile truce between the different fighting groups, on the basis of which Rodriguez Salas, now blamed for the police action against the telephone central, has to resign.

It is tradition that The Rock be burned annually however, it is now so fragile that since 2006 this ceremony is no longer performed.

The southern troops rescue him while the gunfire erupts and, two days later, the fragile relationship between the two Koreas now relies on a special investigation conducted by the led by Major Sophie E. Jang ( Lee Young Ae ) on behalf of the Neutral Nations Supervisory Commission.

The sword wielding nation of Angelio and the magically powerful nation of Zemekia had peacefully emerged from a war-ridden past, but now that alliance grows fragile.