The fruit of most species of Capsicum contains capsaicin ( methyl vanillyl nonenamide ), a lipophilic chemical that can produce a strong burning sensation ( pungency or spiciness ) in the mouth of the unaccustomed eater.

The cleaning action of this mixture is attributed to the action of micelles, tiny spheres coated on the outside with polar hydrophilic ( water-loving ) groups, encasing a lipophilic ( fat-loving ) pocket that can surround the grease particles, causing them to disperse in water.

While the bell pepper is a member of the Capsicum genus, it is the only Capsicum apart from Capsicum rhomboideum that does not produce capsaicin, a lipophilic chemical that can cause a strong burning sensation when it comes in contact with mucous membranes.

MPTP itself is not toxic, and as a lipophilic compound can cross the blood – brain barrier.

However, the terms " lipophilic " and " hydrophobic " are not synonymous, as can be seen with silicones and fluorocarbons, which are hydrophobic but not lipophilic.

E. senticosus contains eleutherosides, triterpenoid saponins that are lipophilic and that can fit into hormone receptors.

The situation may be more complex for lipophilic compounds as they can stick to the tubing or other probe components, resulting in a low or no analyte recovery.

Some researchers have suggested hydrophilic statins such as fluvastatin, rosuvastatin, and pravastatin are less toxic than lipophilic statins such as atorvastatin, lovastatin, and simvastatin, but other studies have not found a connection ; the risk of myopathy was suggested to be lowest with pravastatin and fluvastatin, probably because they are more hydrophillic and as a result have less muscle penetration.

The most common example of this phenomenon is detergents, which clean poorly soluble lipophilic material ( such as oils and waxes ) that cannot be removed by water alone.

Thus lipophilic substances tend to be water insoluble.

:* If the compound is extremely lipophilic or hydrophilic, the concentration in one of the phases will be exceedingly small, and thus difficult to quantify.

It is believed that propylparaben is estrogenic to a certain degree as well, though this is expected to be less than butylparaben by virtue of its less lipophilic nature.

Lipid, ( lipophilic ) or fat soluble substances cannot be diluted, broken down, or excreted in urine, a water-based medium, and so accumulate in fatty tissues of an organism if the organism lacks enzymes to degrade them.

A separatory funnel, also known as separation funnel, separating funnel, or colloquially sep funnel, is a piece of laboratory glassware used in liquid-liquid extractions to separate ( partition ) the components of a mixture into two immiscible solvent phases of different densities Typically, one of the phases will be aqueous, and the other a non-polar lipophilic organic solvent such as ether, MTBE, dichloromethane, chloroform, or ethyl acetate.

( Myelin is non-polar / lipophilic ). It should be noted, however, that bupivacaine also blocks specific potassium channels, an effect contributing to resting membrane potential depolarization.

Based on this hypothesis, the removal of lipophilic, albumin-bound substances such as bilirubin, bile acids, metabolites of aromatic amino acids, medium-chain fatty acids and cytokines should be beneficial to the clinical course of a patient in liver failure.

The active metabolite of fluoxetine remains a long time in the brain because it is lipophilic, with a biological half-life of 4 to 8 days ( the longest of any SSRI ).

The latter differing mainly by the hydroxyl group moving one carbon and the addition of two methyl groups that make the molecule lipophilic ( fat soluble ), ergo capable of crossing the lipid membrane sheaths of the central nervous system.

More specifically, they are amphipathic glycosides grouped, in terms of phenomenology, by the soap-like foaming they produce when shaken in aqueous solutions, and, in terms of structure, by their composition of one or more hydrophilic glycoside moieties combined with a lipophilic triterpene derivative.

LogP is one criterion used in medicinal chemistry to assess the druglikeness of a given molecule, and used to calculate lipophilic efficiency, a function of potency and LogP that evaluate the quality of research compounds.

Ocean sediments are the sink for many persistent organic pollutants, usually lipophilic pollutants like DDT, PCB and PAH.

The simplest examples are methanesulfonic acid, CH < sub > 3 </ sub > SO < sub > 2 </ sub > OH and p-toluenesulfonic acid, which are regularly used in organic chemistry as acids that are lipophilic ( soluble in organic solvents ).

The lipophilic portion is made up of the long hydrocarbon chain from the fatty acid.

Herbal medicine has also employed lipophilic extracts from St John's wort as a topical remedy for wounds, abrasions, burns, and muscle pain.

Lemon verbena extract containing 25 % verbascoside showed strong antioxidant capacity, especially in a lipophilic environment, which was higher than expected as concluded from the antioxidant capacity of pure verbascoside, probably due to synergistic effects.

These salts are derived from the carboxylates of lipophilic carboxylic acids, such as naphthenic acids to make the complexes oil-soluble.

Thiophosphoryl compounds are not active inhibitors of acetylcholinesterase in either mammals or insects ; in mammals, metabolism tends to remove lipophilic side groups from the phosphorus atom while in insects it tends to oxidize the compound, thus removing the terminal sulfur and replacing it with a terminal oxygen, which allows the compound to more efficiently act as an acetylcholinesterase inhibitor.

Those derived from camelid and fish antibodies are less lipophilic and better soluble in water, owing to their complementarity determining region 3 ( CDR3 ), which forms an extended loop ( coloured orange in the ribbon diagram above ) covering the lipophilic site that normally binds to a light chain.

Hydrophobic is often used interchangeably with lipophilic, " fat-loving.

Unlike the acetate salts, acetate esters are often liquids, lipophilic, and sometimes volatile.

Drug metabolism often converts lipophilic chemical compounds into more readily excreted polar products.

Monomerization is usually accomplished by replacing lipophilic by hydrophilic amino acids, but often results in a loss of affinity to the antigen.

Weak bases with lipophilic properties accumulate in acidic intracellular compartments like lysosomes.

A significant part of the clinically approved drugs are lipophilic weak bases with lysosomotropic properties.

Adverse drug reactions ( ADRs ) associated with propranolol therapy are similar to other lipophilic beta blockers ( see beta blocker ).

* Gi proteins are activated upon stimulation with lipophilic odorants.

However, the lipophilic " tails " of surfactant molecules have less contact with water when they are part of a micelle — this being the basis for the energetic drive for micelle formation.

The less lipophilic statins are less prone to cause this reaction, and are probably safer when combined with fibrates.

Additionally, thymol is lipophilic, enabling it to interact with the cell membrane of fungus cells, altering cell membrane permeability permitting the loss of macromolecules.

Benzodiazepines are lipophilic and rapidly penetrate membranes and therefore rapidly penetrate the placenta with significant uptake of the drug.

As a carrier, it is under investigation in conjunction with a lipophilic compound of platinum, and in conjunction with a complex derivative of neocarzinostatin.

Benzodiazepines including oxazepam are lipophilic drugs and rapidly penetrate membranes and therefore rapidly cross over into the placenta with significant uptake of the drug.