The term exon derives from the expressed region and was coined by American biochemist Walter Gilbert in 1978: " The notion of the cistron … must be replaced by that of a transcription unit containing regions which will be lost from the mature messengerwhich I suggest we call introns ( for intragenic regions ) alternating with regions which will be expressedexons.

The boldest, most radical notion in the book is [...] the belief that the individual can and should proceed toward truth by means of his own powers of perception and reasoning ; and that he can in this way discover truths previously unknown.

He added, " the notion that the public would accept Stéphane Dion as prime minister, after having resoundingly rejected that possibility a few weeks earlier, was delusional at best [...] Mr. Dion had seemed to accept responsibility for the defeat ( although somewhat reluctantly ), and should have left his post immediately .".

" In the years of the Jackson presidential campaigns in 1984 and 1988 the RCP's Carl Dix ran as an " anti-candidate [...] running against the notion that oppressed people could rely on the election arena to accomplish positive change.

He wrote in The Jewish Chronicle: " Now, as it happens, I have multiple criticisms of IJV [...] but even their most trenchant opponents must surely blanch at the notion that these critics of Israel and of Anglo-Jewish officialdom are somehow in favour of genocide — literally, eager to see the murder and eradication of the Jewish people [...] it is an absurdity, one that drains the word ' genocide ' of any meaning.

The idea here is one of discharge but this must stand in opposition to a second view, Plato's notion of the arousal of emotion.

We must avoid the notion, suggested to some people by examples such as those just mentioned, that ideas are `` units '' in some way comparable to coins or counters that can be passed intact from one group of people to another or even, for that matter, from one individual to another.

This is to avoid the notion that a writing system that represents sounds must be either a syllabary or an alphabet, which implies that a system like Aramaic must be either a syllabary ( as argued by Gelb ) or an incomplete or deficient alphabet ( as most other writers have said ); rather, it is a different type.

20th-century anthropologists largely reject the notion that all human societies must pass through the same stages in the same order, on the grounds that such a notion does not fit the empirical facts.

Skeat “… in at least three cases and probably in all, in the form of codices " and he theorized that this form of notebook was invented in Rome and then “… must have spread rapidly to the Near East …” In his discussion of one of the earliest pagan parchment codices to survive from Oxyrhynchus in Egypt, Eric Turner seems to challenge Skeat ’ s notion when stating “… its mere existence is evidence that this book form had a prehistory ” and that “ early experiments with this book form may well have taken place outside of Egypt .” Early codices of parchment or papyrus appear to have been widely used as personal notebooks, for instance in recording copies of letters sent ( Cicero Fam.

In light of this, and the practical difficulty of managing such long keys, modern cryptographic practice has discarded the notion of perfect secrecy as a requirement for encryption, and instead focuses on computational security, under which the computational requirements of breaking an encrypted text must be infeasible for an attacker.

In general topological spaces, however, the different notions of compactness are not necessarily equivalent, and the most useful notion, introduced by Pavel Alexandrov and Pavel Urysohn in 1929, involves the existence of certain finite families of open sets that " cover " the space in the sense that each point of the space must lie in some set contained in the family.

In general topological spaces, however, the different notions of compactness are not equivalent, and the most useful notion of compactness — originally called bicompactness — involves families of open sets that " cover " the space in the sense that each point of the space must lie in some set contained in the family.

Common to all gridiron codes is the notion of control — a receiver must demonstrate control of the ball in order to be ruled in possession of it, while still in bounds, as defined by his code.

To be effective, the will must be easily available, and some notion of what it provides must be known to the decedent's survivors.

There is a notion in halakha that violations of the latter are more severe, in certain ways, because of the requirement that one must obtain forgiveness both from the offended person and from God.

However, because the intuitionistic notion of truth is more restrictive than that of classical mathematics, the intuitionist must reject some assumptions of classical logic to ensure that everything he proves is in fact intuitionistically true.

" One of the key legal principles on which Marbury relies is the notion that for every violation of a vested legal right, there must be a legal remedy.

Webster rejected the notion that the study of Greek and Latin must precede the study of English grammar.

He claims to demonstrate that because knowledge can only be had through contingent ( imperfect ) experience, the notion of absolute, uncontingent knowledge must not actually be obtainable, but must function merely as a “ regulative principle ” or heuristic device for problem solving.

In order to understand this argument one must first define the notion of extraterritorial application of a rule.

According to the Stanford Encyclopedia of Philosophy " It must also be recognized that ' forgery ' is a modern notion.

A single reading of the Miles Gloriosus leaves the reader with the notion that the names, place, and play is Greek, but one must look beyond these superficial interpretations.

For example: an apparition of John Wayne is a recurring character and serves as a sort of spiritual guide or conscience for Custer ; Monument Valley and The Alamo serve as backdrops to various legs of the journey ; for a time, Jesse acts as the sheriff of a small town in Texas, and must protect the inhabitants from harm ; the image of the Saint of Killers, a reformed bounty hunter-turned-killer-once-more in the tradition of Clint Eastwood's Unforgiven character, William Munny, is a nod to the classic Western notion of nemesis, straight and true and terrible.

Yet, after Rousseau had given the social contract a new twist with his notion of the General Will, the same philosophy, it may be said, became the idea source of the French Revolution also.

When combined with the metaphysical notion that pure forms of this universe are best appreciated when least embodied in a material substratum, it becomes clear that while earth will be dross on a scale of material-formal ratios, celestial bodies will be of a subtle, quickened, ethereal existence, in whose embodiment pure form will be the dominant component and matter will be absent or remain subsidiary.

In she has it in for George dominant stress will ordinarily be on in, where the notion of stored-up antipathy seems to center.

In such a case, any attitude would be as fitting or unfitting as any other, which means that the notion of fitness has lost all point.

When he heard of his brothers' anger, Palfrey was still hopeful that they could be persuaded to accept his notion of paying wages.

They would like to convey the notion something is being done, even though it is something they know to be ineffectual.

This is the notion that particular cultures should not be judged by one culture's values or viewpoints, but that all cultures should be viewed as relative to each other.

Notably, for skewed distributions, the arithmetic mean may not accord with one's notion of " middle ", and robust statistics such as the median may be a better description of central tendency.

Authors who use this formulation often speak of the choice function on A, but be advised that this is a slightly different notion of choice function.

With this alternate notion of choice function, the axiom of choice can be compactly stated as

He argues that this casts doubt on the notion that recessions are caused by a reallocation of resources from industrial production to consumption, since he argues that the Austrian business cycle theory implies that net investment should be below zero during recessions.

The notion of the Kolmogorov complexity can be used to state and prove impossibility results akin to Gödel's incompleteness theorem and Turing's halting problem.

( Hume 1974: 322 ) In explaining how matters of fact are entirely a product of experience, he dismisses the notion that they may be arrived at through a priori reasoning.

In 1920, Thoralf Skolem simplified a previous result by Leopold Löwenheim, leading to the Löwenheim – Skolem theorem and, in 1930, to the notion of a Herbrand universe and a Herbrand interpretation that allowed ( un ) satisfiability of first-order formulas ( and hence the validity of a theorem ) to be reduced to ( potentially infinitely many ) propositional satisfiability problems.

It had been hoped that patient adherence to antipsychotics would be higher with the atypicals, but a 2008 review found that the data have failed to substantiate the notion that novel antipsychotic drug use leads to improved medication compliance and favorable clinical outcomes.

Indeed, naive set theory might be said to be based on this notion.

Even though the author of the book states that Ruth " just happens " to find Boaz's field ( Ruth 2: 3 ), the reader may be led to accede to the notion that in Bible terms there is no mere chance, but that chance and God's providence amount to the same thing.