A critical role for the ER in calcium signaling was acknowledged before such a role for the mitochondria was widely accepted, in part because the low affinity of Ca < sup > 2 +</ sup > channels localized to the outer mitochondrial membrane seemed to fly in the face of this organelle ’ s purported responsiveness to changes in intracellular Ca < sup > 2 +</ sup > flux.

The actin filaments in the cytoskeleton, the peculiar cell wall, secretory vesicle dynamics, and the flux of ions, to name a few, are some of the fundamental features readily identified as crucial, but whose role has not yet been completely elucidated.

SOLAS has three major focus areas: Biogeochemical interactions and feedbacks between ocean and atmosphere, Exchange processes at the air-sea interface and the role of transport and transformation in the atmospheric and oceanic boundary layers, and Air-sea flux of carbon dioxide and other long-lived radiatively active gases ( this last focus is developed jointly with the Integrated Marine and Biogeochemistry and Ecosystem Research project ; IMBER ).

Using both satellite observations of the Earth's heat balance and atmospheric cooling rates measured by net flux radiosondes, Suomi established the important role played by clouds in absorbing radiated solar energy.

The role of the " field " component is simply to create a magnetic field ( magnetic flux ) for the armature to interact with, so this component can comprise either permanent magnets, or electromagnets formed by a conducting coil.

She had a busy official role from 1932 to 1939 and, following her husband's death, stood for Parliament herself, becoming Australia's first female Member of the House of Representatives, and later first woman in Cabinet, joining the Menzies Cabinet in 1951.

Sherwood's integral involvement with the writing, production and performance of the music led to his formally joining Yes as a full member at the end of the sessions, taking on the role of harmony singer, keyboardist and second guitarist.

After joining as co-host of FLOSS Weekly, a free software / open source ( FLOSS ) themed podcast in 2007, he assumed the role of host in 2010.

The protection against homologous recombination ( HR ) and non-homologous end joining ( NHEJ ) constitutes the essential " capping " role of telomeres that distinguishes them from DNA double-strand breaks ( DSBs ).

He had a small role in Those Magnificent Men in their Flying Machines, joining an all-star cast of British and American TV and film luminaries.

In 1985 he played the Mad Hatter in the Anglia Television serial adaptation of Alice In Wonderland, joining an all-star cast that included Michael Bentine, Leslie Crowther and Leonard Rossiter, and he also had an uncredited role ( as an arcade attendant ) in the Julien Temple film musical Absolute Beginners ( 1986 ) which stars Patsy Kensit.

His predecessors in this role were none other than Richard Niebuhr and George Buttrick, and Buechner was both flattered and daunted by the idea of joining so august a group.

Justin Welch briefly fulfilled the role as drummer, though he only lasted six weeks, before joining Crawley band Spitfire.

Scott Baio and Lynda Goodfriend starred before joining Happy Days the following fall, and Pat Morita reprised his role of Arnold.

Schramm and Lewis left the band after the album's release, with Kaplan subsequently taking on the role of lead guitar and Stephan Wichnewski joining to play bass.

She made her Broadway debut upon joining the cast of the Tony Award-winning play God of Carnage on November 17, 2009, succeeding Hope Davis in the role.

" Writing in Auxiliary Magazine, Luke Copping claimed that Brisco was Campbell's " last great " role before the actor fell into " a period of self-parody and overt camp that he did not redeem himself from until joining the cast of Burn Notice ".

During the episode, Jadzia and Sisko discuss her own training under Curzon Dax, as well as the role that joining plays in Trill society.

Before joining the cast of Holby City, her best-known role had been as the character Judi Jeffreys in the children's television series Grange Hill from 1997 to 1999.

The 1950s were largely marked by Japan re-establishing relations to numerous nations and redefining its international role, e. g., by joining the United Nations in 1956.

As a typesetter for the famous Commercial Press of Shanghai, Chen played a prominent role as a younger organizer in the labor movement during the early and mid 1920s, joining the CPC in 1924.

In June 2009, it was announced that Gates was joining the cast of the International 25th Anniversary World Tour production of Les Misérables in the role of Marius.

He played an active role in Pisa's civic life, for example joining with other notables in 1090 to regulate the maximum height of houses, and by 1092 the clergy were signing his documents.

After World War II, many people chose to join the Danish minority in hopes of joining the much more prosperous Denmark, partly caused by a wish to live in a free and democratic country, partly motivated by social hardships in the aftermath of the war that played another distinctive role, especially as over one million refugees had come to Schleswig-Holstein and also a high proportion of the ' new Danes ' had a lower class background, while only very few of the old elite changed nationality.

The UK health informatics community has long played a key role in international activity, joining TC4 of the International Federation of Information Processing ( 1969 ) which became IMIA ( 1979 ).

Sylvester McCoy would return as the Seventh Doctor three years later in the 1996 telefilm, while Peter Davison, after joining Colin Baker and Sylvester McCoy in the Big Finish audio dramas series, would reprise the role of the Fifth Doctor 14 years later in " Time Crash "-another Children in Need special.

Smits played the role of Congressman Matt Santos of Houston, Texas in the final two seasons of the American television drama The West Wing, joining fellow L. A. Law alumnus John Spencer.

Fellow Conservative MPs generally viewed Bercow with distrust because of his changing political views ( having moved over the years from being very right-wing to become more socially liberal, leading to clashes with past party leaders ), his acceptance of an advisory role from the Labour government ( a party he had often been rumoured to be on the verge of joining ), his general lack of good relations with fellow MPs from his own party, and his vigorous campaigning for the Speaker's job.

He left this role " by mutual consent " on the 13 September 2008 after joining other Labour MPs in declaring that an MP should stand against Gordon Brown.

In Harry Potter and the Order of the Phoenix she had a central role where her character sets firmly in the limelight, with hints of Ginny's greater importance to the overall plot by joining a secret student organisation called Dumbledore's Army that was founded by Harry, Ron and Hermione ( played by Emma Watson ) and eventually goes along with Harry, Ron, Hermione, Neville ( played by Matthew Lewis ) and Luna ( played by Evanna Lynch ) on a mission to rescue Sirius Black ( played by Gary Oldman ) that leads to the climactic battle between Dumbledore's Army and the Order of the Phoenix, Lord Voldemort ( played by Ralph Fiennes ) and the Death Eaters.

It should be added that in man neocortical-hypothalamic interrelations probably play a role in the fusion of emotional processes with those underlying perception, memory, imagination, and creativity.

In neurons, calcium-sensitive adenylate cyclases are located next to calcium ion channels for faster reaction to Ca < sup > 2 +</ sup > influx ; they are suspected of playing an important role in learning processes.

Biological processes play a major role in the removal of contaminants and biotechnology is taking advantage of the astonishing catabolic versatility of microorganisms to degrade / convert such compounds.

Catalysis impacts the environment by increasing the efficiency of industrial processes, but catalysis also plays a direct role in the environment.

This role as a sink for CO < sub > 2 </ sub > is driven by two processes, the solubility pump and the biological pump .< ref > The former is primarily a function of differential CO < sub > 2 </ sub > solubility in seawater and the thermohaline circulation, while the latter is the sum of a series of biological processes that transport carbon ( in organic and inorganic forms ) from the surface euphotic zone to the ocean's interior.

*** A biological science – one that studies the role of chemicals and chemical processes in living organisms.

The Global Ocean Sampling Expedition ( GOS ) is an ocean exploration genome project with the goal of assessing the genetic diversity in marine microbial communities and to understand their role in nature's fundamental processes.

Therefore, it is the role of psychology to provide the foundation of these processes.

The differences in geometry between the various types of unsaturated fatty acids, as well as between saturated and unsaturated fatty acids, play an important role in biological processes, and in the construction of biological structures ( such as cell membranes ).

Despite briefly toying with the name " rational Mesmerism ", Braid ultimately emphasised his approach's uniqueness, carrying out informal experiments throughout his career to refute the arguments invoking supernatural practices, and demonstrate instead the role of ordinary physiological and psychological processes such as suggestion and focused attention in producing the observed effects.

These processes meant the royal courts had a more significant role in local law cases, which had previously been dealt with only by regional or local lords.

Since 1980, linguists studying children, such as Melissa Bowerman, and psychologists following Jean Piaget, like Elizabeth Bates and Jean Mandler, came to suspect that there may indeed be many learning processes involved in the acquisition process, and that ignoring the role of learning may have been a mistake.

* Processing medium, in industrial engineering, a material that plays a role in manufacturing processes

Many observations have indicated that programmed cell death plays a considerable role during physiological processes of multicellular organisms, particularly during embryogenesis and metamorphosis.

COX-1 is a constitutively expressed enzyme with a " house-keeping " role in regulating many normal physiological processes.

Andrey Markov introduced the notion of Markov chains ( 1906 ), which played an important role in stochastic processes theory and its applications.

Here the role and place of music needs to be interpreted through a broader framework in which tradition and ritual are understood as processes of identity and identification, as encoded and embodied forms of collective meaning and memory.

*** A biological science – one that studies the role of physical processes in living organisms.

Other processes substitute other compounds ( such as arsenite ) for water in the electron-supply role ; the microbes use sunlight to oxidize arsenite to arsenate: The equation for this reaction is:

* Sociality Corollary: To the extent that one person construes another's construction processes, that person may play a role in a social process involving the other person.

Also, close ties with the Arab countries ( and the PLO ) allowed Romania to play a key role in the Israel-Egypt and Israel-PLO peace processes by intermediating the visit of Sadat in Israel.

Two separate studies by Melissa Bowerman and Dan I. Slobin treated the role of language in cognitive processes.

Two processes play role in a solder joint formation: interaction between substrate and molten solder, and solid-state growth of intermetallic compounds.

Working memory and attention together play a major role in the processes of thinking.