Captopril is also the only ACE inhibitor which is capable of passing through the blood – brain barrier, although the significance of this characteristic has not been shown to have any positive clinical effects.

The significance of chemotaxis in biology and clinical pathology was widely accepted in the 1930s.

A major change from previous versions was the inclusion of a clinical significance criterion to almost half of all the categories, which required symptoms cause " clinically significant distress or impairment in social, occupational, or other important areas of functioning ".

Subfractions ( HDL-2C, HDL-3C ) can be measured and have clinical significance.

The role of ethanol consumption in acetaminophen overdose is controversial, and a debate that has not yet proven clinical significance.

The veracity and significance of the claims of targeting interfering with clinical priorities are often hard to judge.

This so-called " backwash ileitis " can occur in 10 – 20 % of patients with pancolitis and is believed to be of little clinical significance.

Lymph nodes also have clinical significance.

The clinical significance of the efficacy evidence for TMS in randomized controlled trials was determined by comparison to the published efficacy results for antidepressant pharmacotherapy in similarly designed randomized controlled trials.

Biology has progressed in this field greatly, elucidating complex biochemical mechanisms that appear to underlie diverse aspects of stress, shining a necessary light on its clinical relevance and significance.

The clinical significance of this is that a myocardial infarction involving the PDA is more likely to cause mitral regurgitation.

The clinical significance of this finding is that patients with a baseline of compromised lung function will, over a period of time, develop respiratory distress as a meal progresses.

Feline Coronavirus: 2 forms, Feline enteric coronavirus is a pathogen of minor clinical significance, but spontaneous mutation of this virus can result in feline infectious peritonitis ( FIP ), a disease associated with high mortality.

Freud had earlier covered very similar ground in '" A Child is Being Beaten "'-' they both used material from her analysis as clinical illustration in their sometimes complementary papers ' - in which he highlighted a female case where ' an elaborate superstructure of day-dreams, which was of great significance for the life of the person concerned, had grown up over the masochistic beating-phantasy ... which almost rose to the level of a work of art '.

" The quality of the evidence is not strong and the clinical significance unclear ", the reviewers cautioned.

Usually, people speaking of phosphodiesterase are referring to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below.

Another clinical significance of the femoral triangle is that the femoral artery is positioned at the midinguinal point ( midpoint between the pubic symphysis and the anterior superior iliac spine ); medial to it lies the femoral vein.

The second and third Korotkoff sounds have no known clinical significance.

Its clinical significance is uncertain.

Hepatitis A infection causes no clinical signs and symptoms in over 90 % of infected children and since the infection confers lifelong immunity, the disease is of no special significance to those infected early in life.

According to some placebo-controlled studies that included a sufficiently high number of participants to determine statistical significance of clinical outcomes, the use of black cohosh appears to be safe, but ineffective for treating menopausal hot flashes.

" Flap interface particles " are a finding whose clinical significance is undetermined.

Microfolding has been reported as " an almost unavoidable complication of LASIK " whose " clinical significance appears negligible.

Before an appraisal, the Advisory Committee on Topic Selection ( ACTS ) draws up a list of potential topics of clinical significance for appraisal.

Besides its historical significance as a break with the centuries-old tradition of British insularity, Britain's move, if successful, will constitute an historic landmark of the first importance in the movement toward the unification of Europe and the Western world.

No one could be more devoted than he to the American Congress as an institution and more aware of its historical significance in the political history of the world, and I shall never forget his moving talks, delivered in simple yet eloquent words, upon the meaning of our jobs as Representatives in the operation of representative government and their importance in the context of today's assault upon popular government.

He will discuss the significance of Christian commitment, the necessity of family religion and private devotions, and the importance of the membership preparation sessions.

During the Hellenistic period, the town was of some mercantile importance, although by the first century it had dwindled greatly in size and significance.

In a study of the use of econometrics in major economics journals, McCloskey concluded that economists report p values ( following the Fisherian tradition of tests of significance of point null-hypotheses ), neglecting concerns of type II errors ; economists fail to report estimates of the size of effects ( apart from statistical significance ) and to discuss their economic importance.

The importance of Epictetus ' Stoicism for Stockdale, its role in A Man in Full, and its significance in Gladiator ( 2000 film ) is discussed by William O. Stephens < ref >

This number reveals the importance and significance of life after death and emphasizes that the life of the human being does not end at death but in fact continues afterwards towards a new life-indeed, its true life.

Certain European ritual traits such as the significance of the number 3, the importance of the head and of water sources such as springs remain in the archaeological record, but the differences in the votive offerings made at the Roman Baths ( Bath ), Bath, Somerset before and after the Roman conquest suggest that continuity was only partial.

In the outer circle are those countries where English has official or historical importance (" special significance ").

" Richard Holmes, in 1998, declared the importance of the poem's Preface while describing the reception of the 1816 volume of poems: " However, no contemporary critic saw the larger possible significance of Coleridge's Preface to ' Kubla Khan ', though it eventually became one of the most celebrated, and disputed, accounts of poetic composition ever written.

He further emphasized the importance of dialect studies where appropriate, and noted the significance of sociological factors such as prestige, and the impact of meaning.

A major block to understanding their significance was the importance attached by 19th-century biologists to the apparent blending of inherited traits in the overall appearance of the progeny, now known to be due to multigene interactions, in contrast to the organ-specific binary characters studied by Mendel.

As a foodstuff of great historical and contemporary importance, in many cultures in the West and Near and Middle East bread has a significance beyond mere nutrition.

Madonna and child, folio 7 v of the Book of Kells. As well as their primary spiritual importance, the political significance of religious centres cannot be dismissed.

Russian court had steadily increased in importance throughout the 18th century and came to hold more cultural significance than many of its Western counterparts due its inclusive nature: any “ well to do inhabitants ” were welcome at Court.

An archdiocese is presided over by an archbishop whose see may have or had importance due to size or historical significance.

Sometimes it is not the wrecking of the ship that is important, but the fact that we have access to the remains of it, especially where the vessel was of major importance and significance in the history of science and engineering ( or warfare ), due to being the first of its type of vessel.

The Olympic Games are still the largest multi-sport event in the world in terms of worldwide interest and importance ( though no longer in participation ), but several others also have significance.

It bears no significance with regard to precedence or importance of the particular building or clerics associated with it.

Thus biography can form one part of the larger study of the cultural significance, underlying program, or agenda of a work ; a study which gained increasing importance in the 1980s and early 1990s.

In addition to their scientific importance, archaeological remains sometimes have political or cultural significance to descendants of the people who produced them, monetary value to collectors, or simply strong aesthetic appeal.

Destinations for such pilgrims can include historic sites of national or cultural importance, and can be defined as places " of cultural significance: an artist's home, the location of a pivotal event or an iconic destination.

Throughout the history of Chinese Empires, the area's military importance matches its commercial and agricultural significance.

* The importance and legal significance of hereditary peers has declined steadily following the increase in the appointment of life peers.