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The synthesis of celecoxib was first described in 1997 by a team of researchers at Searle Research and Development.
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synthesis and was
And with the publication of E. T. Leeds' Archaeology Of The Anglo-Saxon Settlements the student was presented with an organized synthesis of the archaeological data then known.
As late as the 1840s, and despite Friedrich Wöhler's synthesis of urea in 1828, some chemists still believed in the doctrine of vitalism, according to which a special life-force was necessary to create organic compounds.
One of the more dramatic successes of his theory was his prediction of the existence of secondary and tertiary alcohols, a conjecture that was soon confirmed by the synthesis of these substances.
Hermann Kolbe was the first person to use the word synthesis in the present day meaning.
This was intended to be the nec plus ultra of reform opera, a completely new synthesis of poetry and music that was an 18th-century anticipation of the ideals of Richard Wagner.
The first complete synthesis of an alkaloid was achieved in 1886 by the German chemist Albert Ladenburg.
This was a culmination of the Russia — US collaboration on the synthesis of elements 113 to 118.
The first convincing synthesis was in 1981 by a German research team led by Peter Armbruster and Gottfried Münzenberg at the Gesellschaft für Schwerionenforschung ( Institute for Heavy Ion Research, GSI ) in Darmstadt using the Dubna reaction.
The synthesis of bohrium was first attempted in 1976 by scientists at the Joint Institute for Nuclear Research at Dubna using this cold fusion reaction.
Bartók's style in his art music compositions was a synthesis of folk music, classicism, and modernism.
B. subtilis is the first bacterium for which the role of an actin-like cytoskeleton in cell shape determination and peptidoglycan synthesis was identified, and for which the entire set of peptidoglycan-synthesizing enzymes was localised.
Cardozo's new " rule " exists in no prior case, but is inferrable as a synthesis of the " thing of danger " principle stated in them, merely extending it to " foreseeable danger " even if " the purposes for which it was designed " were not themselves " a source of great danger.
DWNT synthesis on the gram-scale was first proposed in 2003 by the CCVD technique, from the selective reduction of oxide solutions in methane and hydrogen.
Californium can also be used in nuclear synthesis of higher mass elements ; ununoctium ( element 118 ) was synthesized by bombarding californium-249 atoms with calcium-48 ions.
It was also one of the first books in which the cosmological doctrines of Yinyang and the Five Phases were brought to a mature synthesis.
Further optimization of sulfuric acid technology resulted in the contact process in 1880s, and the Haber process was developed in 1909 – 1910 for ammonia synthesis.
This separation was ended however by the synthesis of urea from inorganic precursors by Friedrich Wöhler in 1828.
It was a work of synthesis, backed by his own personal observations on his travels.
The Fairlight CMI was the first sampling synthesizer, while the Synclavier was originally an FM synthesizer, not adding sampling synthesis until the 1980s.
It used FM synthesis and, although it was incapable of the sampling synthesis of the Fairlight CMI, its price was around $ 2, 000, putting it within range of a much larger number of musicians.
synthesis and first
Three separate sources were combined to form fr. 350, as mentioned above, including a prose paraphrase from Strabo that first needed to be restored to its original meter, a synthesis achieved by the united efforts of Otto Hoffmann, Karl Otfried Muller and Franz Heinrich Ludolf Ahrens.
More recently, hot fusions pathways to bohrium have been re-investigated in order to allow for the synthesis of more long-lived, neutron rich isotopes to allow a first chemical study of bohrium.
During his time at the museum he produced numerous publications on bird taxonomy, and in 1942 his first book, Systematics and the Origin of Species, which completed the evolutionary synthesis started by Darwin.
The first commercially successful emerald synthesis process was that of Carroll Chatham.
Friedrich Wöhler ( 31 July 1800 – 23 September 1882 ) was a German chemist, best known for his synthesis of urea, but also the first to isolate several chemical elements.
In this first phase of his career, Lang alternated between art films such as Der Müde Tod (" The Weary Death ") and popular thrillers such as Die Spinnen (" The Spiders "), combining popular genres with Expressionist techniques to create an unprecedented synthesis of popular entertainment with art cinema.
The first synthesis by Marshall D. Gates, Jr. in 1952 is considered a classic in the field .. Several other syntheses were reported, notably by the research groups of Rice, Evans, Fuchs, Parker, Overman, Mulzer-Trauner, White, Taber, Trost, Fukuyama, Guillou and Stork.
Purines, however, are first synthesized from the sugar template onto which the ring synthesis occurs.
In 1907, total synthesis was commercialized for the first time by Gustaf Komppa with camphor.
* 1951 – Mexican chemist Luis E. Miramontes conducts the very last step of the first synthesis of norethisterone, the progestin that would later be used in one of the first two oral contraceptives.
Chemist John C. Sheehan at MIT completed the first total synthesis of penicillin and some of its analogs in the early 1950s, but his methods were not efficient for mass production.
Key enzymes that synthesize certain amino acids are not present in animals — such as aspartokinase, which catalyzes the first step in the synthesis of lysine, methionine, and threonine from aspartate.
In the first step of peptidoglycan synthesis, the glutamine, which is an amino acid, donates an amino group to a sugar, fructose 6-phosphate.
Studies of retroviruses led to the first demonstrated synthesis of DNA from RNA templates, a fundamental mode for transferring genetic material that occurs in both eukaryotes and prokaryotes.
The synthesis of rutherfordium was first attempted in 1964 by the team at Dubna using the hot fusion reaction of neon-22 projectiles with plutonium-242 targets:
In the first, more philosophically oriented phase, Steiner attempted to find a synthesis between science and mysticism ; his philosophical work of these years, which he termed spiritual science, sought to provide a connection between the cognitive path of Western philosophy and the inner and spiritual needs of the human being.
synthesis and described
Four distinct mechanisms for synthesis have been described.
This is the link between natural selection and genetics, as described in the modern evolutionary synthesis.
While pro wrestling is often described simplistically as a " soap opera for males ", it has also been cited as filling the role of past forms of literature and theatre ; a synthesis of classical heroics, commedia dell ' arte, revenge tragedies, morality plays, and burlesque.
The key advantage of VHDL, when used for systems design, is that it allows the behavior of the required system to be described ( modeled ) and verified ( simulated ) before synthesis tools translate the design into real hardware ( gates and wires ).
If it starts from a product isolated from plants or animals and then proceeds to new compounds, the synthesis is described as a semisynthetic process.
However, sedimentary rocks such as limestone are considered to have resulted from processes like those described by the neptunists, and so modern theory can be seen as a synthesis of the two approaches.
Over time this type of short-memory based oscillator has also become known as wavetable oscillator, which is a degenerate case of wavetable synthesis described above.
Thus, a synthesis of 2-Furonitrile has been described employing the dehydration of 2-furoic acid amide or oxime via flash vacuum pyrolysis over molecular sieves in the gas phase.
Vitally important in the preparation or presentation of many types of food, it is named after chemist Louis-Camille Maillard, who first described it in 1912 while attempting to reproduce biological protein synthesis.
In musical terms, they are often described as sounding hollow, and are therefore used as the basis for wind instrument sounds created using subtractive synthesis.
The reconstruction has been described as " the " first systematic, statistically based synthesis of multiple climate proxies ", and it introduced explicit statistical error bars.
In the United States, a delicatessen store, or deli, is a type of business that could be described as a synthesis of a grocery store and a fast-food restaurant.
Jehuda Reinharz described the book as " valuable synthesis " and " new analysis " that " convincingly demonstrates that many of those who today call themselves Palestinian refugees are former immigrants or children of such immigrants ".
Hardline can be described as a synthesis of deep ecology, straight edge, veganism, animal liberation, with religious philosophies such as Dharmic and Abrahamic morality.
In 1977, Boyer's laboratory and collaborators at City of Hope National Medical Center described the first-ever synthesis and expression of a peptide-coding gene.
His other studies, in collage and relief, have been described by reviewers as " a personal synthesis which is identifiable as his own to this day ", and ranked among " the most courageous and original experiments in abstract art.
In contrast to the library types described above, a randomized mutant library is created by de novo synthesis of a gene.
* Synthesis Science, also called “ science-driven synthesis ,” facilitated by extensive and novel synthesis capabilities in the CNMS ' first five Scientific Themes ( described below ) and by a new Nanofabrication Research Laboratory.
Thus, medical textbooks and nosologies until quite recently described two different diseases: 17α-hydroxylase deficient CAH, and a distinct and even rarer defect of sex steroid synthesis termed 17, 20-lyase deficiency ( which is not a form of CAH ).
Of the Principle of the Commercial or Mercantile System: The book has sometimes been described as a critique of mercantilism and a synthesis of the emerging economic thinking of Smith's time.
The first synthesis of perfectly regioregular PATs was described by McCullough et al.
His system of spiritual practice has been described as a practical synthesis of Vedic and Tantric philosophies.
In one quantitative study, the reduction of nitrobenzene to aniline receives 64 points out of 100 marking it as an acceptable synthesis overall whereas a synthesis of an amide using HMDS is only described as adequate with a combined 32 points.
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