However, drugs delivered directly to the CSF do not effectively penetrate into the brain tissue itself, possibly due to the tortuous nature of the interstitial space in the brain.

The steep gradients and tortuous nature of the route beyond Exeter meant that it was not possible to compete with the Great Western Railway ’ s " Cornish Riviera Express " in terms of speed, but it was a useful alternative route, particularly for passengers from the South and South East of England, who could make a connection at Salisbury and thus avoid travelling via London.

After a few tortuous moments of wondering who `` he '' is, the camera pans across the room to the plaster statue, and we realize that Neitzbohr is trying to redeem himself in the eyes of a mute piece of sculpture.

Two roads connect the adjoining prefectures of Messenia and Laconia: one is a tortuous mountain pass through Taygetus and the other bypasses the mountain via the Mani district to the south.

The Morona is navigable for small craft for about 300 miles above its mouth, but it is extremely tortuous.

Peary's account of a journey to the Pole and back while traveling along the direct line – the only strategy that is consistent with the time constraints that he was facing – is contradicted by Henson's account of tortuous detours to avoid pressure ridges and open leads.

The old town, having grown within fortifications, where every metre of ground was precious, is a labyrinth of narrow streets paved with cobblestones, sometimes tortuous but colourful and clean.

If any portion of the waters of the Amazon runs round the southern side of the large island of Marajó into the river Para, it is only through tortuous, natural canals, which are in no sense outflow channels of the Amazon.

After that Brenner is the highest railway station in Italy, whose tortuous path, characterized by steep slopes, passing through the station Rivisondoli-Pescocostanzo and wedges in the Abruzzo National Park and the Maiella.

The A643 and A6025 provide less important local links, although the A643 is an alternative, but tortuous and poorly-signposted, route through to Leeds.

Radio City is notable for its unique, chewy guitar sound and live-sounding yet meticulous textures, and for its somewhat tortuous recording history.

# The Lower Engadine from Zernez to the Austrian border, where the Inn drops more quickly and its path is more tortuous

The Eustachian tubes and external ear canals may be angled or tortuous, leading to food or other contamination of a part of the body that is normally self cleaning.

An indication of the tortuous route the L & SWR had to take through Exeter is given by the fact that at Exeter St Davids London-bound trains from the two companies faced opposite directions at the platforms.

A labyrinth seal is a type of mechanical seal that provides a tortuous path to help prevent leakage.

It is long, with a tortuous route through the country's mountainous central region, including the Brecon Beacons and Snowdonia National Park.

: The whole book is written like this: facts are selected or misunderstood, tortuous and flimsy arguments are expressed in violent and repetitive language.

Through a series of tortuous means that would make a Bond villain green with envy, the hideous Phibes is matched by Joseph Cotten as the doc at the end of the road.

The most dramatic part of this road journey is the ascent up the 3, 505 m ( 11, 500 ft .) high Zoji-la, a tortuous pass in the Great Himalayan Wall.

he achievement of necessary conditions for communism must take place on a world scale, through a long and tortuous process of revolutionary transformation in which there will be uneven development, the seizure of power in different countries at different times, and a complex dialectical interplay between the revolutionary struggles and the revolutionization of society in these different countries … dialectical relation in which the world arena is fundamentally and ultimately decisive while the mutually interacting and mutually supporting struggles of the proletarians in different countries constitute the key link in fundamentally changing the world as a whole.

The tortuous process of replacing him is covered by Bede briefly, but in some respects puzzlingly.

Also, the tortuous S-shaped path the water is forced to follow offers a significant obstruction to the flow.

In Norse mythology, Gandvik is a dangerous sea, known as ' Bay of Serpents ' because of its tortuous shape.

Their word Wreake indicated that the river followed a tortuous, twisting and turning course.

Although this design makes for simplified and cheap construction, it has two major drawbacks ; the tortuous path followed by the intake charge limits air flow and effectively prevents speeds greater than 2, 000 – 2, 500 RPM, and the travels of the exhaust through the block can cause overheating under sustained heavy load.

In order to improve the mouth of the river, which followed a tortuous route through salt marshes, the construction of a new channel was proposed by Nathaniel Kinderley, and work started on it in 1721.

Green Lantern Guy Gardner once experienced an extended and tortuous stay after an explosion of a Green Lantern Power Battery sent him there, until rescued by Superman and Green Lantern Hal Jordan who had believed him to be dead all that time.

He appears to have been an efficient warden, but was irritated by the vacillating and tortuous conduct of the English queen.

The stele had fallen in the 4th Century and had broken into five pieces which were transported by truck along the tortuous route between Axum and Massawa ( it took five trips over a period of two months ) to the port of Massawa.

These are further classified by the type of branches: upright ( 直枝梅類 ), pendulous ( 垂枝梅類 ), and tortuous ( 龍游梅類 ); and by the characteristics of the flower.

With the United States gaining more control in Middle East, they helped the Shah to re-install himself back into power by creating one of the most tortuous secret polices in the world, Savak.

The evidence brought against defendants, supplied by James McParlan, a Pinkerton, and corroborated by men who were granted immunity for their own crimes, was tortuous and contradictory, but the net effect was damning ...

Dieulafoy's lesion ( exulceratio simplex Dieulafoy ) is a medical condition characterized by a large tortuous arteriole in the stomach wall that erodes and bleeds.

Dieulafoy's Lesions are characterized by a single large tortuous arteriole in the submucosa which does not undergo normal branching or a branch with caliber of 1 – 5 mm ( more than 10 times the normal diameter of mucosal capillaries ).

* Burrow – A burrow appears as a slightly elevated, grayish, tortuous line in the skin, and is caused by burrowing organisms.

The only supply line that was not controlled by the Confederates was a roundabout, tortuous course nearly 60 miles long over Walden's Ridge from Bridgeport, Alabama.

" These cells are characterized by abnormalities in their cytoplasmic structure, such as deramified, atrophic, fragmented or unusually tortuous processes, frequently bearing spheroidal or bulbous swellings.

Rather, its tortuous and uncontained stream meandered over much of the ground now occupied by Lombard Street, William Street, the People's Park, Catherine Street, and Parnell Street, turning this entire area into viscous marshland.

Coming to a small rise, the travelers commenced the portage, which in its eastern reaches was marshy, mosquito-infested, and among the most unpleasant and even tortuous of all the routes taken by the voyageurs.

The trail's route was improbable, to say the least, hugging lakeside cliffs where, in places, trestles and floating platforms had to be built out above or onto the lake and, beyond that, through marshes and heavy forests beset by infamously thick mosquitos and, lastly, a tortuous " stairway " section of the trail over the pass between the Squamish area and the head of the Seymour River, where cattle where expected to use steps on a trail that was nowhere more than 6 yards wide.

This avoids the tortuous legal processes in the judicial system and adds to the accountability among the group.