These modifications include acetylation, methylation, ubiquitylation, phosphorylation and sumoylation.

These techniques are becoming increasingly important for the systematic analysis of complex phosphorylation networks.

These interactions bring these proteins closer together, allowing the intracellular kinases present on the TCR, CD3 and CD4 proteins to activate each other via phosphorylation.

These protein kinases have been linked to growth in dendritic spine volume and LTP processes such as the addition of AMPA receptors to the plasma membrane and phosphorylation of ion channels for enhanced permeability.

The regulation of transcription factors, effector proteins, molecular chaperones, and cytoskeletal proteins by acetylation and deacetylation is a significant post-translational regulatory mechanism These regulatory mechanisms are analogous to phosphorylation and dephosphorylation by the action of kinases and phosphatases.

These H + are then transported down their concentration gradient through an enzyme called ATP-synthase, creating ATP by phosphorylation of ADP to ATP.

These phosphorylation events are essential for the activity of the enzyme, and 3-phosphoinositide-dependent protein kinase-1 ( PDK1 ) is the upstream kinase responsible for initiating the process by transphosphorylation of the activation loop.

These drugs act as prodrugs, which in themselves are not toxic, but are converted to toxic drugs by phosphorylation by viral thymidine kinase.

These proteins contain a number of known common modification domains, including regions for divalent cation interaction, phosphorylation & acetylation, and proteolytic cleavage, among others established and predicted.

These mutations are at nucleotide positions 11778 G to A, 3460 G to A and 14484 T to C, respectively in the ND4, ND1 and ND6 subunit genes of complex I of the oxidative phosphorylation chain in mitochondria.

These genes code for the NADH dehydrogenase protein involved in the normal mitochondrial function of oxidative phosphorylation.

These moments are historical events in the lives of individual authors with which the student of comparative literature must be frequently concerned.

These types include the endosymbiotic events of cyanobacteria, red algae and green algae, leading to the hypothesis of the supergroups Archaeplastida, Chromalveolata and Cabozoa respectively.

These population complexes hosted cultural and civic events and infrastructure that supported a vast outlying region hundreds of miles away linked by transportation roadways.

These events appear to refer to the early part of the year 368 BC.

18 ; 20-21 .</ ref > These examples further show how Anaximenes like the other Milesians looked for the broader picture in nature, seeking unifying causes for diversely occurring events rather than treating each one on a case-by-case basis or attributing them to gods or a personified nature.

These events were especially popular with BBSes that offered chat rooms.

These are commonly seen at external filming locations to feed the cast and crew, and at other large events to feed staff.

These events date Deutero-Isaiah's earlier prophecies.

These events represented a major religious crisis: why had their god allowed this to happen?

These were not targums (" translations ") in the true sense but like the Greek Esther are retellings of events and include additional legends relating to Purim.

These events are usually separated by periods of " normal " mood ; but, in some individuals, depression and mania may rapidly alternate, which is known as rapid cycling.

These events have been dated to approximately the second half of the 11th century BC.

These ideas were informed by events prior to the Great Depression when — in the opinion of Keynes and others — international lending, primarily by the U. S., exceeded the capacity of sound investment and so got diverted into non-productive and speculative uses, which in turn invited default and a sudden stop to the process of lending.

These events are also alleged in the 2004 documentary, The 50 Worst Movies Ever Made.

These events would have released massive amounts of dust and ash into the atmosphere, reducing surface sunlight, hindering photosynthesis, and severely disrupting Earth's biosphere.

These events damaged his reputation among the ancient writers, though more recent historians have revised this opinion.

These events may have been spurred by the action of Constantina, who had since traveled east to marry Gallus.

These squads have become a part of a year-round sport, starting with tryouts in the spring, to year-round practice, to sporting events to cheer at in the fall and winter, and to cheerleading competitions.

" These events don ’ t constitute assassinations because as far as we are concerned assassinations are only those of heads of state.

These companies offer both English-and Spanish-language television, plus a range of channels in other languages, high definition channels, pay-per-view movies and events, sports packages and premium movie channels such as HBO, Playboy TV, Cinecanal, etc.

These are instances in which memories of powerful emotional events are more highly detailed and enduring than regular memories ( e. g. September 11 attacks, assassination of JFK ).

These events were the height of the Pizarro-Almagro friendship, which historians describe as one of the last events in which their friendship soon faded and entered a period of turmoil for the control of the Incan capital of Cuzco.

These included television ads, print ads, and targeting of professional sporting events.

These supershear earthquakes have all been observed during large strike-slip events.

These assumptions lead to an organization with one man at the top, six directly under him, six under each of these, and so on until there are six levels of personnel.

These data lead to a structure in which sheets of Cr atoms lie between two sheets of O atoms.

These roads converge at Pueblo Alto and from there lead north beyond the Canyon limits.

These oncolytic properties provided a promising link between CDV and lymphoma apoptosis which can lead to development of alternative treatment methods for both canine lymphoma and human non-Hodgkin lymphoma.

These effects can lead to significant lead leaching from brasses of comparatively low lead content.

These actions lead Constantinople to become a once again thriving capital of the Ottoman Empire.

These are usually ' temps ' ( temporary workers ) or consultants who, depending on the project and their experience, might be brought on to lead a task for which the skill-set did not exist within the company, or in the case of a temp, in the vernacular sense, to perform busy-work or an otherwise low-skilled repetitive task for which an employee is deemed too valuable to perform.

These changes may be made either by the same writer who made it, or more commonly by an author that has taken over the creative lead of a corporate owned show or publication.

" These sentences are interpreted by many Buddhists ( especially in the West ) as an injunction against supporting any legal measure which might lead to the death penalty.

These tools lead to increasingly dynamic, interactive maps that can be manipulated digitally.

These seizures are often prolonged, and may lead to status epilepticus, a medical emergency.

These aspects of the Federal Reserve System are the parts intended to prevent or minimize speculative asset bubbles, which ultimately lead to severe market corrections.

These people lead a life of misery and are denied the most basic of human rights: the right to food.

These lead naturally to the definition of C *- algebras and other operator algebras.

These smaller bore and gauge shotshells also require much less lead shot, further lessening the impact of the rapid rises seen in the price of lead shot.

These dreams are another factor which has lead some scholars to associate Imhotep with the Biblical figure of Joseph.

These ( and other ) critics have questioned how natural selection operating on individual organisms can lead to the evolution of planetary-scale homeostasis.

These therapy sessions lead to a " psychic affair " between Scott and Emma.

These behaviors may increase stress in personal relationships, lead to problems at work and increase the risk of altercations with law enforcement.

These can lead to possibly fatal or long term health problems for the infant.

These advances would lead Hector Berlioz to write a landmark book on instrumentation, which was the first systematic treatise on the use of instrumental sound as an expressive element of music.

These early investigations did not lead to the use of antibiotics to treat infection because they took place in obscure circumstances, and the idea that infections were caused by transmissible agents was not widely accepted at the time.