In the last few years, the application of chromatographic and other modern techniques to the problem of isolating TSH has led to further purification ( Bates and Condliffe, 1960 ; ;

Another problem was that the gradual identification of more and more chemically similar and indistinguishable lanthanides, which were of an uncertain number, led to inconsistency and uncertainty in the numbering of all elements at least from lutetium ( element 71 ) onwards ( hafnium was not known at this time ).

For instance, the P-38 Lightning with its thick high-lift wing had a particular problem in high-speed dives that led to a nose-down condition.

The feedback problem has led to the development of instruments like the electric upright bass, whose playing characteristics mimic that of the double bass.

The study and the generalization of this problem by Tait, Heawood, Ramsey and Hadwiger led to the study of the colorings of the graphs embedded on surfaces with arbitrary genus.

Keynes argued that when a glut occurred, it was the over-reaction of producers and the laying off of workers that led to a fall in demand and perpetuating the problem.

To explain stellar aberration in the context of an aether-based theory of light was regarded as more problematic, because it requires that the aether be stationary even as the Earth moves through it — precisely the problem that led Newton to reject a wave model in the first place.

Most classes rely on a combination of lectures, recitations led by graduate students, weekly problem sets (" p-sets "), and tests.

The disruption of the river's natural flow, run-off from agriculture, and the introduction of pest species like the European Carp has led to serious environmental damage along the river's length and to concerns that the river will be unusably salty in the medium to long term — a serious problem given that the Murray supplies 40 % of Adelaide's domestic water.

Using a more pragmatic approach to the problem, including assembly code and relying on the processor to enforce concepts normally supported in software led to a new series of microkernels with dramatically improved performance.

This led to the problem that the proposed base of the Pleistocene was at 1. 805 Mya, long after the start of the major glaciations of the northern hemisphere.

However, a problem was encountered: administration to pregnant ewes on many occasions led to abortion.

Such was the case with the Jewish population of the Seleucid empire because the Jews posed a significant problem which eventually led to war.

There are suggestions that the proliferation of poker machines has led to increased levels of problem gambling ; however, the precise nature of this link is still open to research.

Work on Hilbert's 10th problem led in the late twentieth century to the construction of specific Diophantine equations for which it is undecidable whether they have a solution, or even if they do, whether they have a finite or infinite number of solutions.

All of these problems led to another problem, i. e. currency attack.

The destruction of many buildings downtown, along with several failed business ventures in housing in the core, led to a reverse city-suburb wealth problem common in small cities with land to spare.

Leo Strauss ( in The City and Man ) locates the problem in the nature of Athenian democracy itself, about which, he argued, Thucydides had a deeply ambivalent view: on one hand, Thucydides ' own " wisdom was made possible " by the Periclean democracy, which had the effect of liberating individual daring, enterprise and questioning spirit, but this same liberation, by permitting the growth of limitless political ambition, led to imperialism and, eventually, civic strife.

Even though it is apparently simple, the paradox's underlying complexities have even led to it being called a " significant problem " for philosophy.

The relatively small magnitude of the Starfish Prime EMP in Hawaii ( about 5600 volts / metre ) and the relatively small amount of damage done ( for example, only 1 to 3 percent of streetlights extinguished ) led some scientists to believe, in the early days of EMP research, that the problem might not be as significant as was later realized.

On the other hand, further unification of the, mostly Orthodox, Grand Duchy with mostly Catholic Poland led to liberalization and partial solving of the religious problem.

But the rest problem and social welfare function selection, as well as the subjective factors in behavioral finance, has led to a closer analysis of factors of production.

Another mistake was his treatment of circular motion, but this was more fruitful in that it led others to identify circular motion as a problem raised by the principle of inertia.

As a result of this, Drogheda has a serious unemployment problem, which has in turn led to a serious rise in social problems, including crime ( organised, violent and petty ), poverty, lack of affordable housing, homelessness, and various substance abuse.

When the movements of celestial objects convinced Philolaus that the world must be not only turning on its own axis but revolving around a fixed point elsewhere in space, he was faced with the problem of explaining how a spherical world could move in this way without spilling everything on the surface into space.

The only real problem is to devise a plan whereby the owners of the above-water land can develop their property without the public losing its underwater land and the right to its development for public use and enjoyment.

As seen in the B. family, there must be an attempt to help the client develop conscious awareness of the problem, especially in the absence of a formal request for assistance.

After experimenting to develop his ability to stop the unnecessary and habitual contracting in his neck, he found that his problem with recurrent voice loss was resolved.

The solution to the " flavor " problem of EDIF 2 0 0 was to develop a more specific semantic description in EDIF 3 0 0 ( 1993 ).

Brabham took a different approach to the problem of obtaining a suitable engine: he persuaded Australian engineering company Repco to develop a new 3-litre eight-cylinder engine for him.

In response to this problem, some LED lighting systems have been designed with an added heating circuit at the expense of reduced overall electrical efficiency of the system ; additionally, research has been done to develop heat sink technologies that will transfer heat produced within the junction to appropriate areas of the luminaire.

This can be a major problem, as other parts of the spacecraft in shadow develop a negative charge from nearby plasma, and the imbalance can discharge through delicate electrical components.

( See moving magnet and conductor problem for details about the thought experiment that eventually helped Albert Einstein to develop special relativity.

The heuristic approach to problem solving consists of applying human intelligence, experience, common sense and certain rules of thumb ( or heuristics ) to develop an acceptable, but not necessarily an optimum, solution to a problem.

Faced with “ past technical deficiencies in telecommunications systems and equipment and software … that were traced to basic inadequacies in the application of telecommunication standards and to the lack of a well defined … program for their review, control and implementation ”, the U. S. Department of Defense looked to develop a series of standards that would alleviate the problem.

A second problem occurred when government policies allowed, or even encouraged, a housing bubble to develop, " on an immense scale ".

People who have hearing impairments, especially those who develop a hearing problem in childhood or old age, may need the support and technical adaptations as part of the rehabilitation process.

Unaltered male cats are more likely to develop an obstruction in their urethra, preventing them from urinating to some degree ; however, neutering does not seem to make much difference statistically because many neutered toms also have the problem.

In 1982, an educational department was established to develop curriculum programs for reading, math, history, and problem solving, with the most successful program being the Endless Quest book series.

Their children may also be more curious about the world around them and develop greater problem solving skills.

The reason for total outsiders to develop the trains was that they would have no preconceived rail engineering prejudices and would approach the problem with a fresh open mind.

The Police Department, which is a nationally accredited agency, sanctioned by the Commission on Accreditation for Law Enforcement Agencies, has adopted the Problem Oriented Policing philosophy of service delivery, which requires officers to work together with citizens to identify community problems, determine the underlying cause, and develop solutions which address these causes in order to resolve the problem.

But the cosmic mechanism was not an easy problem, and Milanković took 2 years to develop an astronomical theory.

As a method of combating this alleged problem, the PMRC suggested a voluntary move by the RIAA and the music industry to develop " guidelines and / or a rating system " similar to the MPAA film rating system.

John Howard is also the namesake of the John Howard Society, a Canadian non-profit organization that seeks to develop understanding and effective responses to the problem of crime.

The problem soon became how to develop the oil field and ship product to U. S. markets.

For example, about 40 percent of those who begin drinking alcohol before age 15 develop alcohol dependence in later life, whereas only 10 percent of those who did not begin drinking until 20 years or older developed an alcohol problem in later life.

The gene is recessive, and both parents must carry it for the kittens to develop the problem.