Two theories of the direct initiation of apoptotic mechanisms in mammals have been suggested: the TNF-induced ( tumour necrosis factor ) model and the Fas-Fas ligand-mediated model, both involving receptors of the TNF receptor ( TNFR ) family coupled to extrinsic signals.

Gilliam also attempted to direct a version of Charles Dickens's A Tale of Two Cities, which collapsed due to disagreements over its budget and choice of lead actor.

Section Two also requires direct taxes to " be apportioned among the several States ... according to their respective Numbers " and that a census be held every ten years.

Two of his direct descendants attended the ceremony: Dominic, his great-great-grandson ; and George, Dominic's son.

In Hong Kong, those early think tanks established in the late 1980s and early 1990s focused on the political development including first direct Legislative Council members election in 1991 and the political framework of " One Country, Two Systems " manifested in the Sino-British Joint Declaration.

Two years later, Altman was hired to direct the low-budget space travel feature Countdown, but was fired within days of the project's conclusion because he had refused to edit the film to a manageable length.

Terry Hughes directed most of the episodes, and would later direct The Two Ronnies, The Golden Girls and 3rd Rock from the Sun.

* Two points are awarded for a score direct form a sideline cut ( since March 2012 )

Two leading forms of direct democracy are participatory democracy and deliberative democracy.

Two recent studies ( one a meta-analysis ) involving direct comparisons of multiple EI tests yielded very favorable results for the TEIQue.

Two miles south of town off Missouri Highway 100 West is Adam Puchta Winery, the oldest continuously family-owned winery in the nation, under direct family ownership since 1855.

Two direct trains to from Bridgnorth operated by Chiltern Railways ran in 2009, one on August 15 and one on November 28.

Two personalities of direct significance for Cui were women who were specially devoted to his music.

Two trees that shade the stone are said to be direct descendants of Newton ’ s famous apple tree.

Two of three thyristor valve stacks used for long distance transmission of power from Manitoba Hydro damsSince modern thyristors can switch power on the scale of megawatts, thyristor valves have become the heart of high-voltage direct current ( HVDC ) conversion either to or from alternating current.

Two Indonesian airlines are considering the opportunity to open a direct flight from Yogyakarta, Indonesia to Siem Reap.

Two years later, the retired Emperor Go-Fukakusa ended his reign as Cloistered Emperor, and Fushimi took direct control.

The paper never missed an issue throughout the Siege of Malta in World War Two, despite taking direct hits on several occasions.

* Two of Japan's largest cities-Tokyo and Osaka-will be connected by a direct high-speed maglev route.

Two years later, the word " international " was added to the airport's name as Northwest Airlines began direct service to Tokyo, Japan.

Two routes were suggested for the British Section, a western route of about from the tip of Kowloon peninsula via Tsuen Wan to Castle Peak Bay and thence to Yuen Long and the border with China, and a more direct eastern route of about requiring tunnelling through the Kowloon hills and thence to the border via Tide Cove ( now Sha Tin area ), Tai Po, Fanling and Sheung Shui.

Two years later in 1899 " The London Extension " was officially opened to passenger and freight traffic, allowing more direct journeys from the capital to Nottingham, Leicester, Sheffield and Manchester.

Davis would direct one other Goofy Gophers short, 1948's " Two Gophers from Texas ".

Two other issues that must be considered in setting up an absorption spectroscopy experiment include the optics used to direct the radiation and the means of holding or containing the sample material ( called a cuvette or cell ).

Two paths of a P-wave, one direct and one refracted as it crosses the Moho.

Two more sequels followed this, Space Duel in 1982 and Blasteroids in 1987.

Two decades later, Herbert's son Brian Herbert, along with Kevin J. Anderson, published two sequels – Hunters of Dune ( 2006 ) and Sandworms of Dune ( 2007 ) – based on notes left behind by Frank Herbert for what he referred to as Dune 7, his own planned seventh novel in the Dune series.

Two decades after Frank Herbert's death, his son Brian Herbert, along with Kevin J. Anderson, published two sequels – Hunters of Dune ( 2006 ) and Sandworms of Dune ( 2007 ) – based on notes left behind by Frank Herbert for what he referred to as Dune 7, his own planned seventh novel in the Dune series.

Two sequels followed, Defoe's The Farther Adventures of Robinson Crusoe ( 1719 ) and his Serious reflections during the life and surprising adventures of Robinson Crusoe: with his Vision of the angelick world ( 1720 ).

Two filmed sequels followed: Topper Takes a Trip in 1939 and Topper Returns in 1941 — this last film was not based on a book.

Two sequels were later made to the game as well.

Two film sequels, including new contributions by Puzo himself, were made in 1974 and 1990.

Two sequels followed.

Two sequels were attempted and expansions have been released regularly.

Two sequels were planned by Electronic Arts, but both were canceled during development so that more focus could be spent on the original game.

Two less successful sequels: The Toxic Avenger Part II and The Toxic Avenger Part III: The Last Temptation of Toxie were filmed as one.

Horrocks's voiceovers have been used on Chicken Run ( 2000 ), Christmas Carol: The Movie ( 2001 ), Corpse Bride ( 2005 ), Garfield: A Tail of Two Kitties ( 2006 ) and Tinker Bell ( 2008 ) ( in which she was Fairy Mary ; she reprises the role in the Tinker Bell sequels ), and on radio as Fenchurch in the audio adaptation of Douglas Adams ' science fiction series The Hitchhiker's Guide to the Galaxy for BBC Radio 4.

The first significant releases of sequels took place between The Lord of the Rings: The Two Towers, Harry Potter and the Chamber of Secrets, Star Wars Episode II: Attack of the Clones, Men in Black II, Analyze That, Spy Kids 2: The Island of Lost Dreams, Stuart Little 2, Blade II, the 3rd installment Austin Powers in Goldmember, the 10th installments Star Trek Nemesis and Jason X.

Two more sequels were produced: Paradise Lost 3: Purgatory, which was initially scheduled for a fall 2011 release, but was pushed back until January 2012 after the West Memphis Three were released from prison while the film was in post-production, requiring new material to be added, and West of Memphis, which was released at the Sundance Film Festival days after Paradise Lost 3 aired on HBO and, based on new evidence, implicates a new suspect in the murders at Robin Hood Hills.

Two sequels, Tekken 2 and Tekken 3, were released in the same fashion in 1996 and 1998.

Two sequels, Predator 2 ( 1990 ) and Predators ( 2010 ), as well as two crossover films with the Alien franchise, Alien vs.

Two sequels were later made without Newland's involvement: Son of Bambi Meets Godzilla and Bambi's Revenge, giving Godzilla a hot foot.

Two sequels of the book were published, The Haunted Mask II in October 1995 ( the thirty-sixth book in the Goosebumps series ) and The Scream of the Haunted Mask on August 1, 2008 ( the fourth book in the Goosebumps HorrorLand series ).

Two sequels, Halo 2 and Halo 3, a side game, Halo 3: ODST, and a prequel, Halo: Reach, were released in 2004, 2007, 2009, and 2010, respectively.

Two sequels were created, Master of Orion II: Battle at Antares in 1996 and Master of Orion III in 2003-as well as the free, open source FreeOrion which is loosely based on the series.

Two commercial sequels to Master of Orion have been released, Master of Orion II: Battle at Antares and Master of Orion III.

Two further sequels to the d ' Artagnan books, the novels The Son of Porthos and D ' Artagnan Kingmaker, were published respectively in 1883 and 1900.

Two sequels to the first two Fuzzy novels have been written by other authors: Fuzzy Bones ( 1981 ) by William Tuning ISBN 0-441-26181-7, and Golden Dream: A Fuzzy Odyssey ( 1982 ) by Ardath Mayhar ISBN 0-441-29726-9.

Two more sequels were made for SNK's console, the Neo-Geo:

Two years later, it climbed the ranks to number 70 in the updated list, with the games ' legacy again noted to have inspired multiple video game sequels, movies, television shows, and other merchandise, strongly rooting it in popular culture.