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Untreated PKU can lead to mental retardation, seizures, and other serious medical problems.
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Untreated and can
:; Cor pulmonale: Untreated cor pulmonale can cause right heart failure from chronic pulmonary hypertrophy.
Untreated, the cataract can cause phacomorphic glaucoma.
Untreated Cushing's syndrome can lead to heart disease and increased mortality.
Untreated syngas can be run in hybrid turbines that allow for greater efficiency because of their lower operating temperatures, and extended part lifetime.
Untreated, it can prove fatal within 24 hours.
Untreated, the infection may lead to rapid destruction of the periodontium and can spread, as necrotizing stomatitis or noma, into neighbouring tissues in the cheeks, lips or the bones of the jaw.
Untreated, the disease can kill within four or five years.
Untreated type 1 diabetes mellitus can produce weight loss.
Untreated pericoronitis can progress to a much more severe infection.
Untreated, polycythemia vera can be fatal.
* Untreated mental illness, and disability can cause individuals to become paranoid, anxious, or depressed, making it difficult or impossible to maintain employment, pay bills, or keep supportive social relationships.
Untreated organic materials that could decay should not be used as part of a structural wall mass, but can be used as infill.
Untreated babies can have deformities, delays in development, or seizures along with many other problems such as rash, fever, hepatosplenomegaly, anemia, and jaundice.
* Untreated infections: Systemic infections, particularly where caused by bacteria, can cause release of endotoxins into the blood stream.
Untreated organic matter that contains fecal coliform can be harmful to the environment.
Untreated cases can lead to death.
Untreated Douglas fir timber has featured in the leaky homes saga around New Zealand ; it is difficult to treat against decay and untreated timber is suitable for use only where it can be adequately protected from moisture.
Untreated, tyrosinemia can be fatal.
Untreated, the infection can spread to surrounding structures, including the brain, causing serious complications.
Untreated cases can result in serious growth abnormalities and permanent disability.
Untreated rooms have an uneven frequency response, which means that any mixing decisions being made are being based on a sound that is ‘ coloured ’, because sound mixers can ’ t accurately hear what ’ s being played.
Untreated and lead
Untreated myelitis may rapidly lead to a permanently damaged spinal cord.
Untreated, these diseases lead to alveolar bone loss and tooth loss and, to date, continue to be the leading cause of tooth loss in adults.
Untreated and mental
Untreated syphilis results in a syndrome known at the time as " general paresis of the insane " in which mental aberrations are a major symptom and was at the time a frequent cause of institutionalization in insane asylums.
Untreated and other
Untreated birds will begin to tear at the injury site, and other flockmates will begin to cannibalize the prolapse area, a behaviour commonly known as pickout.
Untreated and .
Untreated, septicemic plague is usually fatal.
Untreated children are normal at birth, but fail to attain early developmental milestones, develop microcephaly, and demonstrate progressive impairment of cerebral function.
Untreated scurvy is invariably fatal.
Untreated solid waste is present in the city and outskirts.
** U. S. President Bill Clinton issues a formal apology to the surviving victims of the Tuskegee Study of Untreated Syphilis in the Negro Male and their families.
* July 25 – U. S. health officials admit that African-Americans were used as guinea pigs in the Tuskegee Study of Untreated Syphilis in the Negro Male.
Untreated, cerebral ALD is characterized by progressive demyelination leading to a vegetative state and death.
Untreated sewage effluent and agricultural run-off carrying fertilizers are examples of human-caused eutrophication.
Untreated, mortality is high, mainly because of the risk of rupture leading to peritonitis and shock .< ref name =" hobbler "> Reginald Fitz first described acute and chronic appendicitis in 1886, and it has been recognized as one of the most common causes of severe acute abdominal pain worldwide.
Untreated pneumonic plague has a very high fatality rate.
Untreated, the appendix may rupture, leading to peritonitis, followed by shock, and, if still untreated, death.
Untreated, superficial tumors may gradually begin to infiltrate the muscular wall of the bladder.
Untreated aplastic anemia leads to rapid death, typically within six months.
* Jean Heller ( Associated Press ), " Syphilis Victims in the U. S. Study Went Untreated for 40 Years " New York Times, July 26, 1972: 1, 8.
PKU and can
Other non-PAH mutations can also cause PKU.
If PKU is diagnosed early enough, an affected newborn can grow up with normal brain development, but only by managing and controlling Phe levels through diet, or a combination of diet and medication.
Kuvan is the first drug that can help BH4-responsive PKU patients ( defined among clinicians as about 1 / 2 of the PKU population ) lower Phe levels to recommended ranges.
Working closely with a dietitian, some PKU patients who respond to Kuvan may also be able to increase the amount of natural protein they can eat.
Though the developing fetus may only be a carrier of the PKU gene, the intrauterine environment can have very high levels of phenylalanine, which can cross the placenta.
Testing can reveal conditions that are easily treatable as long as they are detected ( Phenylketonuria or PKU ).
Newborn screening has expanded since the introduction of PKU testing in the 1960s, but can vary greatly between countries.
Newborn screening originated with an amino acid disorder, phenylketonuria ( PKU ), which can be easily treated by dietary modifications, but causes severe mental retardation if not identified and treated early.
With a special diet low in phenylalanine, PKU newborns can grow and develop into normal children and adults.
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