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# Widukind-duke of Saxony and antagonist of Charlemagne during the Saxon Wars
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# and Saxony
# Johann ( b. Dresden, 24 August 1498 – d. Dresden, 11 January 1537 ), Hereditary Duke of Saxony ; married on 20 May 1516 to Elizabeth of Hesse.
# Frederick ( b. Dresden, 15 March 1504 – d. Dresden, 26 February 1539 ), Hereditary Duke of Saxony ; married on 27 January 1539 to Elisabeth of Mansfeld.
# The Quadruple Alliance of 1745 was formed between the United Kingdom, the Dutch Republic, Saxony and Austria in the later stages of the War of the Austrian Succession.
# Frederick Augustus I of Saxony ( 23 December 1750-5 May 1827 ) married Amalie of Zweibrücken-Birkenfeld had issue.
# Anton of Saxony ( 27 December 1755-6 June 1836 ) married Maria Carolina of Savoy no issue ; married Maria Theresa of Austria no surviving issue.
# Maria Amalia of Saxony ( 26 September 1757-20 April 1831 ) married Karl II August of Zweibrücken and had issue.
# Maximilian of Saxony ( 13 April 1759-3 January 1838 ) married Princess Caroline of Parma and had issue ; married secondly Maria Luisa of Bourbon-Parma without issue.
# Maria Carolina of Savoy ( 17 January 1764 – 28 December 1782 ) married Antony, Electoral Prince of Saxony in 1781, no issue.
# East Frisia or Eastern Friesland ( German Ostfriesland ; East Frisian Low Saxon: Oostfreesland ) in Lower Saxony
# and antagonist
* Eddie Martel # 7 ( Brett Cullen ) — Regular first-string quarterback for the Washington Sentinels, two-time Super Bowl winner, and primary antagonist.
Appearing for the first time in The Amazing Spider-Man # 129 ( Feb. 1974 ), the Punisher was initially an antagonist of the titular hero.
The character initially appears as an antagonist to the X-Men, although before long he becomes a member of the Avengers and appears as a regular character in that title beginning with Avengers # 16 in May 1965.
Broome and artist Irwin Hasen created the supervillian Per Degaton as a JSA antagonist in All-Star Comics # 35 ( July 1947 ).
The character initially appeared as an antagonist of the New Mutants and X-Men, but eventually joined the New Mutants in issue # 99 of that series, and the team became known as X-Force in the first issue of that series.
The game contains many features that would later become a staple of the Xiao Xiao series, including revamped animation and character design, most notable the introduction of the series ' main antagonist, " The Boss " ( although he is not referred to by name until Xiao Xiao # 3 ), a magenta-colored crime boss who acts as the final challenge of the game via a boss fight.
* " Muscles " McGinnis-The antagonist of a story included in Captain Marvel Adventures # 3 ( 1941 ), the toughest gangster of the city possessing enormous strength " Muscles " McGinnis promises to go straight after being defeated by Captain Marvel when he tries to take over Whiz Radio Station, as he feels the side opposing crime is much stronger.
An alternate version of Parasite appeared in DC Comics ' All-Star Superman # 5 as an antagonist in the main subplot.
# Competitive antagonist — a molecule that binds to the same site on the receptor protein as the agonist, preventing activation of the receptor
# Non-competitive antagonist — a molecule that binds to a receptor protein on a different site than that of the agonist, but causes a conformational change in the protein that does not allow activation.
Created by writer Roy Thomas and penciler Gil Kane, the character, a living human suffering from vampiric abilities resulting from scientific rather than supernatural means, first appeared as an antagonist in The Amazing Spider-Man # 101 ( Oct. 1971 ), and went on to become a heroic, tragically flawed protagonist in his own series and other titles.
A tragic and sympathetic antagonist in his initial two-issue arc, having acquired his vampiric addiction while researching a cure for his own rare, fatal blood disease, Morbius collided again with Spider-Man and others in Marvel Team-Up # 3-4 ( July & Sept. 1972 ).
During this period, Morbius again appeared as an antagonist in the Spider-Man one-shot, Giant-Size Super-Heroes # 1 ( June 1974 )
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