tolerance

When used appropriately, opioids and similar narcotic analgesics are otherwise safe and effective, however risks such as addiction and the body becoming used to the drug ( tolerance ) can occur.

The effect of tolerance means that frequent use of the drug may result in its diminished effect so, when safe to do so, the dosage may need to be increased to maintain effectiveness.

It is not addictive and tolerance usually does not develop.

However, tolerance may develop in single cases.

Dextromethorphan has been noted to slow the development of tolerance to opioids and exert additional analgesia by acting upon the NMDA receptors ; some analgesics such as methadone and ketobemidone and perhaps piritramide have intrinsic NMDA action.

Some natural tolerance to habitual use of ayahuasca ( roughly once weekly ) may develop through upregulation of the serotonergic system.

Nicotine is believed to act as an antidepressant, by it stimulating the release of dopamine and norepinephrine ; additionally, nicotine is believed to exert an antidepressant effect due to the desensitisation of nicotinic receptors which occurs as a result of tolerance.

In her speech at the 2000 Conservative conference, she called for a zero tolerance policy of prosecution, albeit with only £ 100 fines as the punishment, for users of cannabis.

He suggested that a combination of spiritual exercises ( for example, concentrating on an object such as a seed ), moral development ( control of thought, feelings and will combined with openness, tolerance and flexibility ) and familiarity with other spiritual researchers ' results would best further an individual's spiritual development.

As was common during the years of Islamic expansion from Arabia, religious tolerance was practiced.

Although people of all creeds enjoyed tolerance and freedom of religion under his rule, he repelled the Fatimids, partly by supporting their enemies in Ifriqiya, and partly by claiming the title Caliph ( ruler of the Islamic world ) for himself.

What most troubles me now is the instability of the balance, the extreme peril of the current situation, the appalling waste of the arms race ... Each of us has a responsibility to think about this in global terms, with tolerance, trust, and candor, free from ideological dogmatism, parochial interests, or national egotism.

There is a risk of a benzodiazepine withdrawal and rebound syndrome after continuous usage for longer than two weeks, and tolerance and dependence may occur if patients stay under this treatment for longer.

Long-term trials have shown continued effectiveness without the development of tolerance, and, in addition, unlike benzodiazepines, it does not disrupt sleep architecture and produces less severe cognitive and psychomotor impairment ; it also has a low potential for abuse and dependence and may be preferred over the benzodiazepines for these reasons.

Efficacy of antipsychotics may likewise be reduced over time, due to this development of drug tolerance.

Significant alcohol intake produces changes in the brain's structure and chemistry, though some alterations occur with minimal use of alcohol over a short term period, such as tolerance and physical dependence.

Alcoholism is characterised by an increased tolerance of and physical dependence on alcohol, affecting an individual's ability to control alcohol consumption safely.

With repeated heavy consumption of alcohol, these receptors are desensitized and reduced in number, resulting in tolerance and physical dependence.

With repeated heavy consumption of alcohol, these receptors are desensitized and reduced in number, resulting in tolerance and physical dependence.

Physiological changes are happening with the increase in tolerance, but this will not be noticeable to the drinker or others.

1956 saw the debut of the Bald Iggle, considered by some Abner enthusiasts to be the creative high point of the strip, as well as Mammy's revelatory encounter with the " Square Eyes " Family — Capp ’ s thinly-veiled appeal for racial tolerance.

Frederick William, known as the " Great Elector ", who had succeeded his father George William as ruler in 1640, initiated a policy of promoting immigration and religious tolerance.

The most successful was the American Association ( 1881 – 1891 ), sometimes called the " beer and whiskey league " for its tolerance of the sale of alcoholic beverages to spectators.

In 1250, with the coming to power of the Mamluks under Rukn al-Din Baibars, tolerance of Christianity declined ; the clergies left the city, and in 1263 the town walls were demolished.

Benefits may include antibiotic resistance, xenobiotic tolerance or the ability to use new metabolites.