Binding of molecules uniquely found in microbes — viral glycoproteins, viral RNA, bacterial endotoxin ( lipopolysaccharide ), bacterial flagella, CpG motifs -- by pattern recognition receptors, such as membrane bound Toll like receptors or the cytoplasmic receptors RIG-I or MDA5, can trigger release of IFNs.

It is believed that the mechanisms are multifaceted and include the following: 1 ) Potassium or glutamate leakage through the outer membrane of bacteria ; 2 ) Osmotic balance disturbances ; 3 ) Binding to proteins that do not require or utilize copper ; 4 ) Oxidative stress by hydrogen peroxide generation.

" The Binding of Fenrir " ( 1908 ) by George Hand Wright | George Wright

Fenrir has been depicted in the artwork " Odin and Fenris " ( 1909 ) and " The Binding of Fenris " ( around 1900 ) by Dorothy Hardy, " Odin und Fenriswolf " and " Fesselung des Fenriswolfe " ( 1901 ) by Emil Doepler, and is the subject of the metal sculpture " Fenrir " by A. V. Gunnerud located on the island of Askøy, Norway.

According to the traditional counting cited by Rashi, Isaac was 37 years old at the time of the Binding of Isaac, and news of Rebekah's birth reached Abraham immediately after that event.

Binding of Isaac | The Sacrifice of Isaac by Caravaggio, ( 1590 – 1610 ; Oil on canvas ; Uffizi ).

* Lectures on Government and Binding: The Pisa Lectures, a book by American linguist Noam Chomsky

Binding of these C-termini into these 20S pockets by themselves stimulates opening of the gate in the 20S in much the same way that a " key-in-a-lock " opens a door.

It was presented by Leslie Phillips and included new interviews with Betty Marsden and Barry Took, period interviews with Kenneth Horne, and rare excerpts from surviving wartime episodes of Much Binding in the Marsh.

* “ An Act of Love ” in Liavek: Spells of Binding ( 1988, with Gregory Frost and Megan Lindholm ; edited by Emma Bull and Will Shetterly )

The Iroquois Confederacy or League, combining five to six American Indian nations or tribes before the U. S. became a nation, operated by The Great Binding Law of Peace, a constitution by which women participated in the League's political decision-making, including deciding whether to proceed to war, through what may have been a matriarchy or "' gyneocracy '".

# Binding of the alcohol substrate by coordination to zinc ;

On that reading, in the original E version of the Binding Abraham disobeys God ’ s command, sacrificing the ram “ instead of his son ” ( v. 13 ) on his own responsibility and without being stopped by an angel: " And Abraham stretched forth his hand, and took the knife to slay his son ; but Abraham lifted up his eyes and looked and beheld, behind him was a ram, caught in a thicket by his horns ; and Abraham went, and took the ram, and offered it up as a burnt offering instead of his son " ( v. 10, 13 ).

* Curse tablets and Binding Spells from the Ancient World by John G. Gager ISBN 0-19-506226-4

* Binding of oxygen by hemoglobin

* Regemorter, Berthe van, Binding Structures in the Middle Ages, ( translated by J. Greenfield ), 1992, Bibliotheca Wittockiana, Brussels

Binding of SP to NK-1 results in internalization by the clathrin-dependent mechanism to the acidified endosomes where the complex disassociates.

In conjunction with the National Information Standards Organization, the Library Binding Institute has published standards of library binding that should be used by all binding companies.

In 1979, the brewery was taken over by Binding Bier Mainz, and then closed and torn down in 1987.

Binding between the target molecule to be separated and the binding molecule on the column beads can be modeled using a simple equilibrium reaction K < sub > eq </ sub > =

Papyrus is what he called ' Space Binding '.

The other is stone and ' Time Binding ', through the construction of temples and the pyramids can sustain their authority generation to generation, through this media they can change and shape communication in their society ( Wark, McKenzie 1997 ).

Binding of cardiac glycoside to Na-K ATPase is slow, and also, after binding, intracellular calcium increases gradually.

Binding is typically machine sewn to the front side of the edge of the quilt, folded over twice, and hand sewn to the back side of the quilt.

The operation of setting up a session between two processes is called " Binding ".

The distinction between lexical and functional categories plays a big role in Chomskyan grammars ( Transformational Grammar, Government and Binding Theory, Minimalist Program ), where the role of the functional categories is large.

Binding is what links the certificate to the identity.

He similarly designed the small " Scorpion " on the small end of the scale which is documented in John McPhee's The Curve of Binding Energy.

One must keep in mind, though, that PRO-theory is particular to one tradition in the study of syntax and grammar ( Government and Binding Theory, Minimalist Program ).

In the indie videogame The Binding of Isaac, the Book of Shadows is an obtainable item which can be activated to provide temporary invincibility.

Binding between monomers is relatively weak, and ODC interconverts rapidly between monomeric and dimeric forms in the cell.

Binding energy is the mechanical energy required to disassemble a whole into separate parts.

The oldest building in the five-building complex is the two-story brick Binding Building ( 1888 ).

The Binding of Isaac ( in Hebrew the ע ֲ ק ֵ יד ַ ת י ִ צ ְ ח ַ ק, Akedát Yitzḥák, also known simply as " The Binding " ה ָ) ע ֲ ק ֵ יד ָ ה ), the Akedah or Aqedah, or in Arabic as the Dhabih ( ذبيح ) or " Slaughter "), is a story from the Hebrew Bible in which God asks Abraham to sacrifice his son, Isaac, on Mount Moriah.

The Binding of Isaac is mentioned in the New Testament Epistle to the Hebrews among many acts of faith recorded in the Old Testament: By faith Abraham, when he was tested, offered up Isaac, and he who had received the promises offered up his only begotten son, of whom it was said, " In Isaac your seed shall be called ," concluding that God was able to raise him up, even from the dead, from which he also received him in a figurative sense.

This analysis of the story sheds light on the connection between the Binding and the story of Sodom (), in which Abraham protests against God's unethical plan to destroy the city, without distinguishing between the righteous and the wicked: " Far be it from you to do such a thing .. Shall not the judge of all the earth do what is just?

The character Sol Weintraub analyses the Binding often during the novel, coming to the conclusion that it is Abraham who is testing God, and God is serious about killing an innocent child for him, he would not be worthy to be followed or obeyed.

Binding of suxamethonium to the nicotinic acetylcholine receptor results in opening of the receptor's monovalent cation channel ; a disorganized depolarization of the motor end-plate occurs and calcium is released from the sarcoplasmic reticulum.

Binding energy values are normally reported as positive values with units of eV.

Maimonides deals with the problem of evil ( for which people are considered to be responsible because of free will ), trials and tests ( especially those of Job and the story of the Binding of Isaac ) as well as other aspects traditionally attached to God in theology, such as providence and omniscience: " Maimonides endeavors to show that evil has no positive existence, but is a privation of a certain capacity and does not proceed from God ; when, therefore, evils are mentioned in Scripture as sent by God, the Scriptural expressions must be explained allegorically.

Binding exposes its active site, allowing it to permanently ribosylate the Gs alpha subunit of the heterotrimeric G protein.

Binding to the active site on the receptor regulates receptor activation directly.

Binding of the SH3 domain results in misalignment of residues within the kinase domain's active site inactivating the enzyme.

Binding of GTP inherently changes the activity of the G proteins through some kind of conformational change in the G proteins which makes them more active, such as the loss of inhibitory subunits.