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** Increase platelet adhesiveness
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** and platelet
** platelet count < 80, 000 / mm < sup > 3 </ sup > or 50 % drop from maximum in chronically thrombocytopenic patients, OR
** HELLP is characterized by hemolysis on peripheral blood smear with serum lactate dehydrogenase > 600 IU / L ; serum aspartate aminotransferase > 70 IU / L ; and platelet count < 100, 000 / μL.
** " The diagnosis of HELLP syndrome required the presence of thrombocytopenia ( perinatal platelet nadir ≤ 150, 000 cells / μL ), evidence of hepatic dysfunction ( increased aspartate aminotransferase level of ≥ 40 IU / L, increased alanine aminotransferase level of ≥ 40 IU / L, or both, with increased lactate dehydrogenase level of ≥ 600 IU / L ), and evidence of hemolysis ( increased LDH level, progressive anemia )...."
** " Class 1 HELLP syndrome featured severe thrombocytopenia with a platelet nadir of ≤ 50, 000 cells / μL, class 2 HELLP syndrome featured moderate thrombocytopenia with a platelet nadir between > 50, 000 and ≤ 100, 000 cells / μL, and class 3 HELLP syndrome featured mild thrombocytopenia with a platelet nadir between > 100, 000 and ≤ 150, 000 cells / μL.
** Myelotoxicity or bone marrow suppression, potentially leading to thrombocytopenia or blood platelet deficiency and / or leukopenia or white blood cell ( WBC ) deficiency
Increase and platelet
platelet and adhesiveness
The antithrombotic effect of dextran is mediated through its binding of erythrocytes, platelets, and vascular endothelium, increasing their electronegativity and thus reducing erythrocyte aggregation and platelet adhesiveness.
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