* 1455 – John Cicero, Elector of Brandenburg ( d. 1499 )

* 1499 – First engagement of the Battle of Zonchio between Venetian and Ottoman fleets.

An extensive account of the teaching of the Catholic Church on Anointing of the Sick is given in Catechism of the Catholic Church, 1499 – 1532.

File: Leonardo da vinci, Study for the Burlington House Cartoon. jpg | Leonardo da Vinci-The Virgin and Child with Saint Anne and the Infant Saint John the Baptist (' The Burlington House Cartoon ') ( c. 1499 – 1500 )

On 10 May 1499, Cesare married Charlotte of Albret ( 1480 – 11 March 1514 ).

They were parents to a daughter, Louise Borgia, Duchess of Valentinois, ( 1500 – 1553 ) who first married Louis II de La Tremouille, Governor of Burgundy, and secondly Philippe de Bourbon ( 1499 – 1557 ), Seigneur de Busset.

# John Albert ( 20 September 1499, Ansbach – 17 May 1550, Halle ), Archbishop of Magdeburg from 1545 to 1550.

The Renaissance saw the continuation of interest in magic that had been found in the Mediaeval period, and in this period, there was an increased interest in Hermeticism amongst occultists and ceremonial magicians in Europe, largely fuelled by the 1471 translation of the ancient Corpus hermeticum into Latin by Marsilio Ficino ( 1433 – 1499 ).

# Wolfgang ( b. Dresden, 1499 – d. Dresden, 12 January 1500 ).

The first clear and credible reference to smallpox inoculation in China comes from Wan Quan's ( 1499 – 1582 ) Douzhen xinfa ( 痘疹心法 ) of 1549, which states that some women unexpectedly menstruate during the procedure, yet his text did not give details on techniques of inoculation.

* 1499 – Portuguese explorer Nicolau Coelho returns to Lisbon, after discovering the sea route to India as a companion of Vasco da Gama.

* 1499 – Louis XII of France marries Anne of Brittany.

* 1499 – Battle of Dornach – The Swiss decisively defeat the Imperial army of Emperor Maximilian I.

John II (; 2 August 1455 – 9 January 1499 ) was Elector of Brandenburg from 1486 until his death, the fourth of the House of Hohenzollern.

Joachim I Nestor ( 21 February 1484 – 11 July 1535 ) was a Prince-elector of the Margraviate of Brandenburg ( 1499 – 1535 ).

* 1499 – Pope Pius IV ( d. 1565 )

Michelangelo returned to Florence in 1499 – 1501.

* 1499 – Publication of the Catholicon in Tréguier ( Brittany ).

* 1499 – Pretender to the throne Perkin Warbeck is hanged for reportedly attempting to escape from the Tower of London.

Niccolò Fontana Tartaglia (; 1499 / 1500, Brescia – 13 December 1557, Venice ) was an Italian mathematician, engineer ( designing fortifications ), a surveyor ( of topography, seeking the best means of defense or offense ) and a bookkeeper from the then-Republic of Venice ( now part of Italy ).

* 1499 – Claude of France, wife of Francis I of France ( d. 1524 )

Colombia was discovered by Europeans when the first expedition of Alonso de Ojeda arrived at the Cabo de la Vela in 1499.

Spanish-sponsored explorers discovered both the leeward ( Alonso de Ojeda, 1499 ) and windward ( Christopher Columbus, 1493 ) island groups, but Spain founded settlements only in the leeward islands.

The recorded history of Guyana can be dated back to 1499, when Alonso de Ojeda ` s first expedition arrived from Spain at the Essequibo river.

In 1499 Alonso de Ojeda ` s first expedition arrived from Spain at the Essequibo river becoming the first Europeans to discover Guyana.

Spanish explorer Alonso de Ojeda is regarded as the first European to arrive in about 1499.

The first European to reach the region may have been the Spaniard Alonso de Ojeda in 1499.

From Europe's point of view, Zulia was first seen in 1499 during an expedition commanded by Alonso de Ojeda.

The first European to discover the bay was Alonso de Ojeda on August 24, 1499, on a voyage with Amerigo Vespucci ( the same one for which the American continents were named ).

Some think that the ABC islands were first discovered by one of Christopher Columbus ' captains, Alonso de Ojeda, who landed on Curaçao in May of 1499.

In 1499 Alonso de Ojeda explored the mouths of the Orinoco and allegedly was the first European to explore the Essequibo.

The first Spanish conquerors that sighted to the coastline of the present day Sucre Department were Alonso de Ojeda, Juan de la Cosa, Rodrigo de Bastidas and Francisco Cesar around 1499.

* Fray Alonso de Burgos ( 1485 – 1499 )

It was discovered by westerners in 1499 when an expedition commanded by Alonso de Ojeda in which he was accompanied by Amerigo Vespucci, explored the Venezuelan coasts compiling information and naming the new lands, said expedition arrived to the gulf after passing through the Netherlands Antilles and the Peninsula of Paraguaná.

* 1499 – Diane de Poitiers, French mistress of Henry II of France ( d. 1566 )

* January 26 – Pierre de Monte, 50th Grandmaster of the Knights Hospitaller ( b. 1499 )

* April 25 – Diane de Poitiers, mistress of King Henry II of France ( b. 1499 )

* Diane de Poitiers ( 1499 – 1566 ): official mistress of King Henry II of France

By 1499, however, Cardinal Francisco Jiménez de Cisneros grew frustrated with the slow pace of the efforts of Granada's first Archbishop, Fernando de Talavera, to convert non-Christians to Christianity and undertook a program of forced Christian baptisms, creating the Converso ( convert ) class for Moors and Jews.

* October 23 – Bernardino de Sahagún, Franciscan missionary ( b. 1499 )

de: 1499

After 1499, the de jure rights of Jerusalem and Cyprus were lost to the Savoy family.

In La Celestina by Fernando de Rojas ( 1499 ) Calisto talks briefly about the unfortunate Pyramus and Thisbe.

Diane de Poitiers ( 3 September 1499 – 25 April 1566 ) was a French noblewoman and a prominent courtier at the courts of kings Francis I and his son, Henry II of France.

Though they were technically part of the Holy Roman Empire, they had become de facto independent when the Swiss defeated Emperor Maximillian in 1499.

The use of Basque language ( Euskera ) terminology in the present territory of Colombia goes back to the early exploration occurred in 1499, during the third voyage of Columbus, it is said that from that time the territory experienced a strong presence of Basques including prominent figures such as the pilot and geographer Juan de la Cosa, nicknamed " El Vizcaino " ( although some sources claim that reputable and solvent was not a native of the Basque Country, but was born in Santona, Cantabria ).

Also, when the Old Swiss Confederacy gained its formal independence from the Empire in 1648 ( it had been de facto independent since 1499 ), the independence of the Imperial Cities of Basel, Bern, Lucerne, St. Gallen, Schaffhausen, Solothurn, and Zürich was formally recognized.

* February 28-Domingo de Santo Tomás, grammarian ( born 1499 )