* 1455 – John Cicero, Elector of Brandenburg ( d. 1499 )

* 1499 – First engagement of the Battle of Zonchio between Venetian and Ottoman fleets.

An extensive account of the teaching of the Catholic Church on Anointing of the Sick is given in Catechism of the Catholic Church, 1499 – 1532.

File: Leonardo da vinci, Study for the Burlington House Cartoon. jpg | Leonardo da Vinci-The Virgin and Child with Saint Anne and the Infant Saint John the Baptist (' The Burlington House Cartoon ') ( c. 1499 – 1500 )

On 10 May 1499, Cesare married Charlotte of Albret ( 1480 – 11 March 1514 ).

They were parents to a daughter, Louise Borgia, Duchess of Valentinois, ( 1500 – 1553 ) who first married Louis II de La Tremouille, Governor of Burgundy, and secondly Philippe de Bourbon ( 1499 – 1557 ), Seigneur de Busset.

# John Albert ( 20 September 1499, Ansbach – 17 May 1550, Halle ), Archbishop of Magdeburg from 1545 to 1550.

The Renaissance saw the continuation of interest in magic that had been found in the Mediaeval period, and in this period, there was an increased interest in Hermeticism amongst occultists and ceremonial magicians in Europe, largely fuelled by the 1471 translation of the ancient Corpus hermeticum into Latin by Marsilio Ficino ( 1433 – 1499 ).

# Wolfgang ( b. Dresden, 1499 – d. Dresden, 12 January 1500 ).

The first clear and credible reference to smallpox inoculation in China comes from Wan Quan's ( 1499 – 1582 ) Douzhen xinfa ( 痘疹心法 ) of 1549, which states that some women unexpectedly menstruate during the procedure, yet his text did not give details on techniques of inoculation.

* 1499 – Portuguese explorer Nicolau Coelho returns to Lisbon, after discovering the sea route to India as a companion of Vasco da Gama.

* 1499 – Battle of Dornach – The Swiss decisively defeat the Imperial army of Emperor Maximilian I.

John II (; 2 August 1455 – 9 January 1499 ) was Elector of Brandenburg from 1486 until his death, the fourth of the House of Hohenzollern.

Joachim I Nestor ( 21 February 1484 – 11 July 1535 ) was a Prince-elector of the Margraviate of Brandenburg ( 1499 – 1535 ).

* 1499 – Alonso de Ojeda sets sail from Cadiz on his voyage to what is now Venezuela.

* 1499 – Pope Pius IV ( d. 1565 )

Michelangelo returned to Florence in 1499 – 1501.

* 1499 – Publication of the Catholicon in Tréguier ( Brittany ).

* 1499 – Pretender to the throne Perkin Warbeck is hanged for reportedly attempting to escape from the Tower of London.

Niccolò Fontana Tartaglia (; 1499 / 1500, Brescia – 13 December 1557, Venice ) was an Italian mathematician, engineer ( designing fortifications ), a surveyor ( of topography, seeking the best means of defense or offense ) and a bookkeeper from the then-Republic of Venice ( now part of Italy ).

* 1499 – Claude of France, wife of Francis I of France ( d. 1524 )

Louis XII invaded Italy in 1499: after Gian Giacomo Trivulzio had ousted its duke Ludovico Sforza, Cesare accompanied the king in his entrance into Milan.

Between 1499 and 1512 he carried out several diplomatic missions: to the court of Louis XII in France ; to the court of Ferdinand II of Aragón, in Spain ; in Germany ; and to the Papacy in Rome, in the Italian states.

* July 20 – Claude of France, queen of Louis XII of France ( b. 1499 )

Louis married the equally reluctant queen dowager, Anne, in 1499.

Ludovico, having betrayed the French at Fornovo, retained his throne until 1499, when Charles's successor, Louis XII of France, invaded Lombardy and seized Milan, to which he had a claim in right of his paternal grandmother Valentina Visconti.

After Charles ' death, la Palice accompanied the new King, Louis XII, in the campaign for Milan, which the French captured in 1499.

In 1499 nearly one and a half centuries of Milanese rule ended with the invasion of Milan by Louis XII of France.

In 1499 nearly one and a half centuries of Milanese rule in Bellinzona ended with the invasion of Milan by Louis XII of France.

Ludovico, having betrayed the French at Fornovo, retained his throne until 1499, when Charles's successor, Louis XII of France, invaded Lombardy and seized Milan.

On March 9, 1503, Louis XII of France, who had invaded Lombardy in 1499, wrote to the commander of Milan requesting that he intervene on behalf of the artists.

In June 1499, then described as prothonotary, he went on an embassy to Louis XII of France, and on his return occupied the position of king's secretary.

* Cesare Borgia, in 1499 by Louis XII

Between 1496 and 1499 Giocondo was invited to France by Louis XII, and made royal adviser.

He accompanied Louis and entered with him into Milan 6 October 1499 ; he was charged with organizing that province under French control, then returned to France in November.

The Second Italian War ( 1499 – 1504 ), sometimes known as Louis XII's Italian War or the War over Naples, was the second of the Italian Wars ; it was fought primarily by Louis XII of France and Ferdinand II of Aragon, with the participation of several Italian powers.

In 1499 Louis XII invaded Lombardy and seized Milan, to which he had a claim in right of his paternal grandmother Valentina Visconti, Duchess of Orléans.

In 1499, Louis concluded an alliance with the Republic of Venice and Swiss mercenaries and invaded the Duchy of Milan.

* 1499 – Diane de Poitiers, French mistress of Henry II of France ( d. 1566 )

* April 25 – Diane de Poitiers, mistress of King Henry II of France ( b. 1499 )

* Diane de Poitiers ( 1499 – 1566 ): official mistress of King Henry II of France

* Mary Boleyn ( 1499 – 1543 ): mistress of King Henry VIII of England and ( allegedly ) lover of King Francis I of France

Diane de Poitiers ( 3 September 1499 – 25 April 1566 ) was a French noblewoman and a prominent courtier at the courts of kings Francis I and his son, Henry II of France.

Between 1499 and 1795 the town was controlled by the House of Nassau ( as did Breda in the Netherlands, Dillenburg in Germany and Orange in France ) which was also the family of the Princes of Orange who at the end of the Napoleonic Wars became in 1815 the kings and queens of the Netherlands after the termination of the Dutch republic at the hands of revolutionary forces in 1795.

Following the death of his major patron, Alfonso ( 1495 ), in 1499 he received his villa " Mergellina " near Naples from Frederick IV, but when Frederick capitulated to France and Aragon, he followed him into exile in France in 1501, whence he returned to Mergellina after Frederick's death at Tours ( 1504 ).

In 1499 he was recalled to court, and accompanied the King on a state visit to France in the following year.

* Jean de Baudricourt, Lord of Choiseul and Bailiff of Chaumont ( died 1499 ), Marshal of France in 1486

* Jacques de Trivulce, Marquis of Vigevano ( 1448 – 1518 ), Marshal of France in 1499

* Treaty of Blois ( 1499 ), an alliance between France and Venice against the Duchy of Milan.

Claude of France () ( 13 October 1499 – 20 July 1524 ) was a princess and queen consort of France and ruling Duchess of Brittany.

The name Reine Claude ( French for " Queen Claude "), by which they are known in France, is in honour of Claude ( 1499 – 1524 ), the Duchess of Brittany, who became the queen consort of King Francis I of France ( 1494 – 1547 ).