* 1521 – Tenochtitlan ( present day Mexico City ) falls to conquistador Hernán Cortés.

* 1521 – Martin Luther's first appearance before the Diet of Worms to be examined by the Holy Roman Emperor Charles V and the other estates of the empire.

Category: People of the Polish – Teutonic War 1519 – 1521 ( German side )

* 1521 – The Ottoman Turks occupy Belgrade.

* 1521 – The Ottoman Turks capture Nándorfehérvár, now known as Belgrade.

* 1521 – Battle of Villalar: King Charles I of Spain defeats the Comuneros.

* 1521 – Trial of Martin Luther over his teachings begins during the assembly of the Diet of Worms.

* 1521 – Zhengde Emperor of China ( b. 1491 )

* 1521 – Battle of Mactan: Explorer Ferdinand Magellan is killed by natives in the Philippines led by chief Lapu-Lapu.

* 1521 – Ferdinand Magellan, Portuguese explorer ( b. 1480 )

* 1521 – Pope Urban VII ( d. 1590 )

* 1521 – Ferdinand Magellan arrives at Cebu.

A fishing colony was established on the island about 1521 – 22 by the Portuguese under João Álvares Fagundes.

Cuauhtémoc ( also known as Cuauhtemotzin, Guatimozin or Guatemoc ; c. 1495 – 28 February 1525 ) was the Aztec ruler ( tlatoani ) of Tenochtitlan from 1520 to 1521.

* 1521 – Takeda Shingen, Japanese warlord ( d. 1573 )

* 1521 – Pope Leo X ( b. 1475 )

* 1475 – Pope Leo X ( d. 1521 )

* 1597 – Petrus Canisius, Dutch Jesuit ( b. 1521 )

* 1521 – Pope Sixtus V ( d. 1590 )

* 1521 – Manuel I of Portugal ( b. 1469 )

The only pre-Columbian North American rulers to be commonly called emperors were the Hueyi Tlatoani of the Aztec Empire ( 1375 – 1521 ).

* Sebastian Brant ( 1457 – 1521 )

* 1521 – Pope Leo X excommunicates Martin Luther in the papal bull Decet Romanum Pontificem.

Though he participated at the Diet of Worms, April 1521, he never saw or spoke with Martin Luther.

Martin Luther's powerful testimony of faith at the Diet of Worms in 1521 made an indelible impression upon his mind, and the vigorous sermons of evangelical preachers in the pulpits of St. Lawrence and St. Sebald in Nuremberg, during the diet there in 1522, deepened the impression.

* 1521 – The Diet of Worms ends when Charles V, Holy Roman Emperor, issues the Edict of Worms, declaring Martin Luther an outlaw.

* Diet of Worms ( 1521 ), where Martin Luther was declared a heretic.

Martin Luther's excommunication on January 3, 1521, from the Catholic Church, was a main cause for the Protestant Reformation.

* Luther, Martin ( 1521 ).

Fisher has also been named, though without any real proof, as the true author of the royal treatise against Martin Luther entitled " Assertio septem sacramentorum " ( The Defense of the Seven Sacraments ), published in 1521, which won for King Henry VIII the title " Fidei Defensor " ( Defender of the Faith ).

* Sermon ... agayn ye pernicyous doctrin of Martin Luther ( London, 1521 );

As Holy Roman Emperor, Charles called Martin Luther to the Diet of Worms in 1521, promising him safe conduct if he would appear.

* Luther, Martin ( 1521 ) Passional Christi und Antichristi.

In 1521, Martin Luther had published ' De votis monasticis ' (' On the monastic vows '), a treatise which declared that the monastic life had no scriptural basis, was pointless and also actively immoral in that it was not compatible with the true spirit of Christianity.

The Antichrist, by Lucas Cranach the Elder – 1521, commissioned by Martin Luther.

From May 1521 until March 1522, Martin Luther stayed at the castle, after he had been taken there for his safety at the request of Frederick the Wise following his excommunication by Pope Leo X and his refusal to recant at the Diet of Worms.

At their urging, while traveling in Germany in 1521, he made himself present at the Diet of Worms to hear Martin Luther speak.

The Diet of Worms 1521 (, ) was a diet ( a formal deliberative assembly, specifically an Imperial Diet ) that took place in Worms, Germany, and is most memorable for the Edict of Worms ( Wormser Edikt ), which addressed Martin Luther and the effects of the Protestant Reformation.

In 1521, Martin Luther was placed under the Ban of the Empire, and he retired to the Wartburg Castle.

The first meeting of Philip of Hesse with Martin Luther took place in 1521 at the Diet of Worms, where he was attracted by the Luther's personality, though he had at first little interest in the religious elements of the gathering.

Henry had been declared " Defender of the Faith " ( Fidei Defensor ) in 1521 by Pope Leo X for his pamphlet accusing Martin Luther of heresy.

The district is named after the Wartburg, a castle near Eisenach most famous as the place of residence of Ludwig, Landgrave of Thuringia and his wife, Saint Elizabeth of Hungary ; and, as Martin Luther's refuge in 1521.

They included the 1521 bull of excommunication of Martin Luther and a letter from Mary, Queen of Scots, written while awaiting her execution.

At the 1521 Diet of Worms Emperor Charles V had Martin Luther banned and the proliferation of his writings prohibited, which in 1529 provoked the Protestation at Speyer by several Lutheran estates.