Reverend Abraham Pierson ( 1646 – March 5, 1707 ) was the first rector, from 1701 to 1707, and one of the founders of the Collegiate School — which later became Yale University.

In 1646, Don Juan de Palafox y Mendoza, bishop of Puebla and Viceroy of New Spain, expelled the Jesuits from New Spain, and with the confiscated books founded the Biblioteca Palafoxiana — the first public library in New Spain.

However, as the war progressed and Royalist fortunes waned, Ashby — already the target of action in 1644 — was subject to a prolonged siege between September 1645 and its surrender in March 1646.

The Wewelsburg was destroyed several times during its history, during the Thirty Years ' War in 1646 by the occupation of Swedish troops — namely by the army under the Swedish general Carl Gustav Wrangel.

However, as the war progressed and Royalist fortunes waned, Ashby — already the target of action in 1644 — was subject to a prolonged siege between September 1645 and its surrender in March 1646.

The English physician and philosopher, Sir Thomas Browne, specifically employed the word encyclopaedia for the first time in English as early as 1646 in the preface to the reader to describe his Pseudodoxia Epidemica or Vulgar Errors, a series of refutations of common errors of his age.

Bacon's ideas were influential in the 1630s and 1650s among scholars, in particular Sir Thomas Browne, who in his encyclopaedia Pseudodoxia Epidemica ( 1646 – 1672 ) frequently adheres to a Baconian approach to his scientific enquiries.

On 21 March 1646, the Royalists, commanded by Sir Jacob Astley, were defeated at the Battle of Stow-on-the-Wold, with hundreds of prisoners being confined for some time in St. Edwards.

Such beliefs were examined wittily and at length in 1646 by Sir Thomas Browne in his Pseudodoxia Epidemica.

In 1645 Sir Thomas Fairfax led the New Model Army through the town on the way to capturing Bristol, and in 1646 the church organ was apparently destroyed by Cromwellian soldiers.

* Sir Godfrey Kneller, 1st Bt ( 1646 – 1723 ), artist

In 1646, Sir Thomas Browne wondered why the natives of North America had taken rattlesnakes with them, but not horses: " How America abounded with Beasts of prey and noxious Animals, yet contained not in that necessary Creature, a Horse, is very strange ".

In the Battle of Torrington ( 1646 ), the Parliamentarians, led by Sir Thomas Fairfax, swept into the town and defeated Lord Hopton's forces.

The English word electricity was first used in 1646 by Sir Thomas Browne, derived from Gilbert's 1600 New Latin electricus, meaning " like amber ".

* Sir Randolph Crewe ( 1559 – 1646 ), Lord Chief Justice, was born in Nantwich.

Sir Godfrey Kneller, 1st Baronet ( 8 August 1646 – 19 October 1723 ) was the leading portrait painter in England during the late 17th and early 18th centuries, and was court painter to English and British monarchs from Charles II to George I.

In 1646 he was given a regiment in the New Model, serving with Sir Thomas in the west of England, and he was a commissioner, with Cromwell and others, for the surrender of Oxford in the same year.

The collection grew larger over the years as individual Benchers such as Sir John Finch and Sir John Bankes left books or money to buy books in their wills, and the first Librarian was appointed in 1646 after members of the Inn had been found stealing books.

During the Civil War, Sir Arthur Basset, brother of Sir Francis, held the Mount against the parliament until July 1646.

Sir Francis Windebank ( 1582 – 1 September 1646 ) was an English politician who was Secretary of State under Charles I.

* 1633 – 1646: Sir Robert Spottiswood of New Abbey

In 1646 Sir William Brereton commanded the Parliamentarians in the second siege against the Royalists led by Colonel Leveson.

* Sir Walter Devereux, 2nd Baronet ( 1578 – 1658 ) ( succeeded as Viscount Hereford in 1646 )

* Thomas Thynne ( 1646 – 1682 ), nephew of Sir James Thynne, grandson of Sir Thomas Thynne.

* Sir Charles Shirley, 3rd Baronet ( 1623 – 1646 )

The son of the Lord Keeper of the Great Seal Sir Orlando Bridgeman, 1st Baronet, of Great Lever, and Judith Kynaston, and older brother of Sir Orlando Bridgeman, 1st Baronet, of Ridley, he was called to the Bar, Inner Temple in 1646, and succeeded in his father's baronetcy on 25 June 1674.

* Andronicus, or the Unfortunate Politician, a 1646 satire by Thomas Fuller

This association gave rise to the English words " electric " and " electricity ", which made their first appearance in print in Thomas Browne's Pseudodoxia Epidemica of 1646.

* 1586 – Thomas Howard, 21st Earl of Arundel, English statesman and art collector ( d. 1646 )

* 1622 – 1646 Thomas Bainbridge

Soldiers were billeted here during the English Civil War and Oliver Cromwell visited for discussions with the general and parliamentary commander-in-chief Thomas Fairfax, 3rd Lord Fairfax of Cameron in 1646.

* July 7 – Thomas Howard, 21st Earl of Arundel, English courtier ( d. 1646 )

In 1646, Thomas Francis was put in command of the French expedition sent south to take the Tuscan forts, after which he was to advance further south to Naples, drive out the Spanish and put himself on the throne of the kingdom ; but the expedition set off late, and when he besieged Orbetello, the supporting French fleet was defeated by the Spanish and he was forced to raise the siege and conduct a difficult retreat, which he performed so poorly that Cardinal Mazarin subsequently despised his command ability, viewed him as incompetent, and declined to appoint him to the expedition that France sent to support the Naples revolt late in 1647 ( this did not stop Mazarin from considering him as a potential candidate for a French-backed King of Naples, though Paris was so slow to move on this that Henry II, Duke of Guise was adopted by the Neapolitans instead ).

In 1646, Thomas was put in command of the French expedition sent south to take the Tuscan forts, after which he was to advance further south to Naples, drive out the Spanish and put himself on the throne of the kingdom ; but the expedition set off late, and when he besieged Orbetello, the supporting French fleet was defeated by the Spanish and he was forced to raise the siege and conduct a difficult retreat, which he performed so poorly that Cardinal Mazarin subsequently despised his command ability, viewed him as incompetent, and declined to appoint him to the expedition that France sent to support the Naples revolt late in 1647 ( this did not stop Mazarin from considering him as a potential candidate for a French-backed King of Naples, though Paris was so slow to move on this that Henry II, Duke of Guise was adopted by the Neapolitans instead ).

* Thomas Howard, 21st Earl of Arundel ( 1585 – 1646 ), prominent English courtier during the reigns of King James I and King Charles I

* Thomas Howard, Earl of Arundel and Surrey 1622 – 1646

He married again soon after, his second wife being Anne Ken ( 1646 – 1662 ); the pastoral Kenna of The Angler's Wish ; stepsister of Thomas Ken, afterwards bishop of Bath and Wells.

A long siege ensued from June 1646 until 15 March 1647, when the garrison of 44 men surrendered to Major-General Thomas Mytton.

The Archbishop defected to Parliament, the town of Conwy fell in August 1646 and in November General Thomas Mytton finally took the castle itself after a substantial siege.

" Veterinarian " was first used in print by Thomas Browne in 1646.

Hopton was defeated at Torrington on 16 February 1646 and surrendered to Thomas Fairfax.

* Thomas Howard, 1st Earl of Norfolk ( 1585 – 1646 )