Clonidine has found use as an analgesic for this same purpose and all of the mentioned drugs potentiate the effects of opioids overall.

Clonidine has been investigated and prescribed first as an antihypertensive drug in the 1950s.

Clonidine along with methylphenidate has been studied for treatment of ADHD.

Clonidine also has several off-label uses, and has been prescribed to treat psychiatric disorders including stress, sleep disorders, and hyperarousal caused by post-traumatic stress disorder, borderline personality disorder, and other anxiety disorders.

Clonidine has also been found to prolong the effects of analgesia when used together with a local anesthetic such as ropivacaine or levobupivacaine.

Clonidine also has peripheral alpha agonist activity which can lead to hypertension-especially when it is injected intravenously.

Clonidine and other imidazoline compounds have also been shown to reduce muscle spasms by their central nervous system activity.

Clonidine is a sympatholytic medication used to treat medical conditions, such as high blood pressure, some pain conditions, ADHD and anxiety / panic disorder.

Clonidine is used to treat anxiety and panic disorder.

Clonidine is increasingly used in conjunction with stimulants to treat attention-deficit hyperactivity disorder ( ADHD ), for which it is administered in late afternoon or evening for sleep, and because it sometimes helps moderate ADHD-associated impulsive and oppositional behavior, and may reduce tics, a problem in which a part of the body moves repeatedly and suddenly.

# Clonidine may reduce withdrawal symptoms and " approximately doubles abstinence rates when compared to a placebo ," but its side effects include dry mouth and sedation, and abruptly stopping the drug can cause high blood pressure and other side effects.

Clonidine may be used to ease withdrawal symptoms associated with the long-term use of narcotics, alcohol and nicotine ( smoking ).

Clonidine can be used for migraine headaches and hot flushes associated with menopause.

Clonidine is a centrally-acting α-adrenergic receptor agonist with more affinity for α < sub > 2 </ sub > than α < sub > 1 </ sub >.

Clonidine, 2 -( 2, 6-dichlorophenylamino ) imidazoline, is synthesized from 2, 6-dichloroaniline, the reaction of which with ammonium thiocyanate gives N -( 2, 6-dichlorophenyl ) thiourea.

: C02LC51 Clonidine and diuretics, combinations with other drugs

* Clonidine can work in patients with reduced sympathetic activity.

Clonidine mimics catecholamines in the brain, causing it to reduce the activity of the sympathetic nerves controlling the adrenal medulla.

* Clonidine: antihypertensive effects decreased and risk of ( massive ) rebound hypertension.

Clonidine is used for dystonic spasms and can be of help.

Clonidine premedication reduces the need for anaesthetic induction agents, as well as the need for volatile anaesthetic agents during maintenance of general anaesthesia, and the need for postoperative analgesics.

Clonidine premedication also reduces postoperative shivering, postoperative nausea and vomiting and emergence delirium.

Clonidine is also a mild sedative, and can be used as premedication before surgery or procedures.

Clonidine treats high blood pressure by stimulating α < sub > 2 </ sub > receptors in the brain, which decreases cardiac output and peripheral vascular resistance, lowering blood pressure.

Clonidine is typically available as tablets ( Catapres, Dixarit ), extended-release tablets ( Kapvay ), as a transdermal patch ( Catapres-TTS ), or as an injectable form to be given i. m., i. v.

Clonidine can be used in Restless Legs Syndrome.

Clonidine may also cause hypotension.

Besides I heard her old uncle that stays there has been doin' it ''.

Southern resentment has been over the method of its ending, the invasion, and Reconstruction ; ;

The situation of the South since 1865 has been unique in the western world.

The North should thank its stars that such has been the case ; ;

As it is, they consider that the North is now reaping the fruits of excess egalitarianism, that in spite of its high standard of living the `` American way '' has been proved inferior to the English and Scandinavian ways, although they disapprove of the socialistic features of the latter.

In what has aptly been called a `` constitutional revolution '', the basic nature of government was transformed from one essentially negative in nature ( the `` night-watchman state '' ) to one with affirmative duties to perform.

For lawyers, reflecting perhaps their parochial preferences, there has been a special fascination since then in the role played by the Supreme Court in that transformation -- the manner in which its decisions altered in `` the switch in time that saved nine '', President Roosevelt's ill-starred but in effect victorious `` Court-packing plan '', the imprimatur of judicial approval that was finally placed upon social legislation.

Labor relations have been transformed, income security has become a standardized feature of political platforms, and all the many facets of the American version of the welfare state have become part of the conventional wisdom.

Historically, however, the concept is one that has been of marked benefit to the people of the Western civilizational group.

In recent weeks, as a result of a sweeping defense policy reappraisal by the Kennedy Administration, basic United States strategy has been modified -- and large new sums allocated -- to meet the accidental-war danger and to reduce it as quickly as possible.

The malignancy of such a landscape has been beautifully described by the Australian Charles Bean.

There has probably always been a bridge of some sort at the southeastern corner of the city.

Even though in most cases the completion of the definitive editions of their writings is still years off, enough documentation has already been assembled to warrant drawing a new composite profile of the leadership which performed the heroic dual feats of winning American independence and founding a new nation.

Madison once remarked: `` My life has been so much a public one '', a comment which fits the careers of the other six.

Thus we are compelled to face the urbanization of the South -- an urbanization which, despite its dramatic and overwhelming effects upon the Southern culture, has been utterly ignored by the bulk of Southern writers.

But the South is, and has been for the past century, engaged in a wide-sweeping urbanization which, oddly enough, is not reflected in its literature.

An example of the changes which have crept over the Southern region may be seen in the Southern Negro's quest for a position in the white-dominated society, a problem that has been reflected in regional fiction especially since 1865.

In the meantime, while the South has been undergoing this phenomenal modernization that is so disappointing to the curious Yankee, Southern writers have certainly done little to reflect and promote their region's progress.

Faulkner culminates the Southern legend perhaps more masterfully than it has ever been, or could ever be, done.

The `` approximate '' is important, because even after the order of the work has been established by the chance method, the result is not inviolable.

But it has been during the last two centuries, during the scientific revolution, that our independence from the physical environment has made the most rapid strides.

In the life sciences, there has been an enormous increase in our understanding of disease, in the mechanisms of heredity, and in bio- and physiological chemistry.

Even in domains where detailed and predictive understanding is still lacking, but where some explanations are possible, as with lightning and weather and earthquakes, the appropriate kind of human action has been more adequately indicated.

The persistent horror of having a malformed child has, I believe, been reduced, not because we have gained any control over this misfortune, but precisely because we have learned that we have so little control over it.