In particular the so-called Plague of Justinian had ravaged the region and conflict remained endemic, with the Three-Chapter Controversy sparking religious opposition and administration at a standstill after the able governor of the peninsula, Narses, was recalled.

The Plague of Justinian in the 6th and 7th centuries is the first known attack on record, and marks the first firmly recorded pattern of bubonic plague.

However, the social fabric of Constantinople was also damaged by the onset of Plague of Justinian between 541 – 542 AD.

A devastating outbreak of bubonic plague ( see Plague of Justinian ) in the early 540s marked the end of an age of splendor.

Already weakened by the Slavic invasions at the end of the 6th century, which ruined the agrarian economy of Macedonia and probably also by the Plague of Justinian in 547, the city was almost totally destroyed by an earthquake around 619, from which it never recovered.

All three forms are widely believed to have been responsible for a number of high-mortality epidemics throughout human history, including the Plague of Justinian in 542 and the Black Death that accounted for the death of at least one-third of the European population between 1347 and 1353.

Biovar Antiqua is thought to correspond to the Plague of Justinian ; it is not known whether this biovar also corresponds to earlier or smaller epidemics of bubonic plague, or whether these were even truly bubonic plague.

* 541-542: First pandemic of bubonic plague ( Plague of Justinian ) hits Constantinople and the rest of Byzantine Empire.

* Plague of Justinian: Bubonic plague appears suddenly in the Egyptian port of Pelusium, spreading to Alexandria and, the following year, to Constantinople.

* Plague of Justinian: Bubonic plague, spread from Egypt, kills at least 230, 000 in Constantinople ( before counting stops ) and perhaps two million or more in the rest of the Empire.

* Plague of Justinian, a pandemic in 541 – 542 AD in the Byzantine Empire

Unsanitary conditions and overcrowding were widespread throughout Europe and Asia during the Middle Ages, resulting periodically in cataclysmic pandemics such as the Plague of Justinian ( 541-42 ) and the Black Death ( 1347 – 1351 ), which killed tens of millions of people and radically altered societies.

David Keys ' book speculates that the climate changes may have contributed to various developments, such as the emergence of the Plague of Justinian, the decline of the Avars, the migration of Mongolian tribes towards the West, the end of the Persian Empire, the rise of Islam, and the fall of Teotihuacán.

* Plague of Justinian

This is probably the Plague of Justinian, that began in Egypt in 541, reached Constantinople in 542 and went on to Italy in 543.

A characteristic of the Plague of Justinian was hand necrosis

The Plague of Justinian ( 541 – 542 AD ) was a pandemic that afflicted the Eastern Roman Empire ( Byzantine Empire ), including its capital Constantinople.

A genetic study of the bacterium causing bubonic plague, based on samples taken from skeletal remains of 14th-century plague victims in London and a survey of other samples, suggests that the Plague of Justinian ( and others from antiquity ) arose from either now-extinct strains of Yersinia pestis, genetically distinct from the strain that broke out in the 14th century pandemic, or from pathogens entirely unrelated to bubonic plague.

It is estimated that the Plague of Justinian killed as many as 25 million people across the world.

Cambridge: Loeb-Harvard UP, 1954 .— Chapters XXII and XXIII of Book II ( pages 451 – 473 ) are Procopius's famous description of the Plague of Justinian.

simple: Plague of Justinian

The first epidemic of bubonic plague dates back to the mid 500s, known as the Plague of Justinian.

# REDIRECT Plague of Justinian

Perhaps the greatest blow came in the wake of the Extreme weather events of 535 – 536 and subsequent Plague of Justinian, when the remaining trade networks ensured the Plague spread to the remaining commercial cities.

The Plague is in part a historical allegory, in which the plague signifies the German occupation of France from 1940 to 1944 during World War II.

Camus draws from his own experience of isolation during the war in writing The Plague.

A Plague Inflicted on Israel While Eating the Quail ( illustration from the 1728 Figures de la Bible )

There is some controversy over the identity of the disease, but in its virulent form, after the Great Plague of Marseille in 1720 – 1722, the Great Plague of 1738 ( which hit Eastern Europe ), and the Russian plague of 1770-1772, it seems to have gradually disappeared from Europe.

Scholars such as Frederick W. Mote argue that the wide drop in numbers reflects an administrative failure to record rather than an actual decrease ; others such as Timothy Brook argue that the Mongols created a system of enserfment among a huge portion of the Chinese populace, causing many to disappear from the census altogether ; other historians like William McNeill and David Morgan argue that the Bubonic Plague was the main factor behind the demographic decline during this period.

Shortly before his birth, his mother had to move from Milan to Pavia to escape the Plague ; her three other children died from the disease.

The regulation of labor by the State as one of its functions dates from the 15th century, when the Black Plague killed around half of the European population.

" () commands, in reference to God's sparing of the firstborn from the Tenth Plague: And this day shall be unto you for a memorial, and ye shall keep it a feast to the lord ; throughout your generations ye shall keep it a feast by an ordinance for ever.

Bubonic plague victims in a mass grave from Great Plague of Marseille | 1720 – 1721 in Martigues, France

< span style =" font-size: 90 %;"> ( Red Faction )</ span ></ ref > Parker learns from Gryphon about Dr. Capek, who created " The Plague ".

As he had done during the Fire and the Plague, Pepys again removed his wife and his gold from London.

He has won Shazam Awards for Best Inker ( Humor Division ) in 1972 for his work on Mad Magazine, and for Best Humor Story in 1972 for " The Poster Plague " from House of Mystery # 202 ( with Steve Skeates ).

Though uncredited, Vangelis also wrote the theme music for the 1992 French motion picture, " La Peste " ( The Plague ) from director Luis Puenzo.

It is possible that infected inhabitants may have fled to Italy, thus spreading the Black Death to Europe, though this is likely only one of a few routes that could have brought the Plague from the East.

* A pandemic known as the Antonine Plague breaks out in Rome after the Roman army returns from Parthia.

* September 15 – 17 – Plague Riot in Moscow resulting from an outbreak of bubonic plague which kills 57, 000.

* Plague kills almost all the monks in a Northumbrian monastery, aside from the abbot and one small boy – future scholar Bede.

* July – Dancing Plague of 1518, a case of dancing mania in Strasbourg in which many people died from constant dancing.

Plague broke out in the barbarian host and their food ran short, and at the same time troops arrived from the east, sent by Marcian to the aid of Italy.

This voyage – the first after his return from Padua – lasted three years, taking Harvey through the countries of France and Spain during the Mantuan War and Plague.