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* Selective dopamine reuptake inhibitors
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Selective and reuptake
Selective serotonin reuptake inhibitors ( SSRIs ) are the class of antidepressants commonly used as the first-line treatment for depression because they have a favorable side effect profile and low toxicity.
Selective serotonin reuptake inhibitors or serotonin-specific reuptake inhibitor ( SSRIs ) are a class of compounds typically used as antidepressants in the treatment of depression, anxiety disorders, and some personality disorders.
Selective serotonin reuptake inhibitors are likely to be the best choice of pharmacotherapy for many patients with panic disorder, but benzodiazepines are also often used, and some studies suggest that these medications are still used with greater frequency than the SSRIs.
Selective serotonin reuptake inhibitors ( SSRIs ) selectively block the reuptake of serotonin ( 5-HT ) through their inhibiting effects on the sodium / potassium ATP-dependent serotonin transporter in presynaptic neurons.
Selective serotonin reuptake inhibitor ( SSRI ) antidepressants might be indicated for use in men with small penis syndrome.
During investigation, it was revealed that Nishizawa had taken a large dose of SSRI medication ( SSRI ( Selective serotonin reuptake inhibitors ) are antidepressants used in the treatment of depression ) before the episode, and he said that he hijacked the plane because he wanted to fly it under the Rainbow Bridge in Tokyo.
* Selective serotonin reuptake inhibitor anti-depressants ( SSRIs ), because of their serotonergic effect, would seem to help IBS, especially patients who are constipation predominant.
Selective serotonin reuptake inhibitor ( SSRI ) antidepressants are believed to act in these nuclei, as well as at their targets.
Selective serotonin reuptake inhibitor ( SSRI ) antidepressants are believed to act at these nuclei.
Selective and inhibitors
Selective serotonin re-uptake inhibitors, SSRI's, frequently prescribed for panic and / or anxiety disorder and depression, affect serotonin in the gut as well as the brain.
dopamine and reuptake
Norepinephrine-dopamine reuptake inhibitors inhibit the neuronal reuptake of dopamine and norepinephrine.
Of the sites tested, it was found to significantly act only on the dopamine transporter ( DAT ), inhibiting the reuptake of dopamine with an IC < sub > 50 </ sub > value of 4 μM.
Accordingly, it produces locomotor activity and extracellular dopamine concentrations in a manner similar to the selective dopamine reuptake inhibitor ( DRI ) vanoxerine, and also blocks methamphetamine-induced dopamine release.
Cocaine, for example, blocks the reuptake of dopamine back into the presynaptic neuron, leaving the neurotransmitter molecules in the synaptic gap longer.
Most of the TCAs inhibit the reuptake of norepinephrine, though not dopamine, and as a result, they show some efficacy in remedying the disorder.
Notably, the TCAs have negligible affinity for the dopamine transporter ( DAT ), and therefore have no efficacy as dopamine reuptake inhibitors ( DRIs ).
In order to control the amount of dopamine in the synaptic cleft, and the amount of dopamine binding to post synaptic terminals, presynaptic dopaminergic neurons function to reuptake the excess dopamine.
Most of the behavioral and physiological actions of cocaine can be explained by its ability to block the reuptake of the two catecholamines, dopamine and norepinephrine, as well as serotonin.
This blockage of dopamine reuptake explains cocaine's addictive properties, as dopamine is the critical neurotransmitter for reward.
The inhibition of dopamine reuptake by cocaine also inhibits the firing of spontaneous action potentials by the pars compacta.
The mechanism by which cocaine inhibits dopamine reuptake involves its binding to the dopamine transporter protein, or DAT.
After dopamine has performed its synaptic duties, it is taken up via reuptake back into the presynaptic cell by either the high-affinity dopamine transporter ( DAT ) or the low-affinity plasma membrane monoamine transporter ( PMAT ).
In most areas of the brain, including the striatum and basal ganglia, dopamine is inactivated by reuptake via the DAT, then enzymatic breakdown by MAO into DOPAC.
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