The Sikeston Micropolitan Statistical Area consists of all of Scott County.

It is the principal city of the Sikeston Micropolitan Statistical Area, which consists of all of Scott County, and has a total population of 41, 143.

** Sikeston Kindergarten Center ( K )

** Sikeston 5th & 6th Grade Center ( 05-06 )

** Sikeston 7th & 8th Grade Center ( 07-08 )

Missouri Delta Medical Center was founded in Sikeston in 1948.

* The Sikeston Career & Technology Center

* Three Rivers Community College Center located at 103 Kathleen Street, Sikeston.

* The major city employers include Unilever, Missouri Delta Medical Center, the Sikeston Public Schools system, and Wal-Mart.

* Other Sikeston businesses include AgMart Sales, Clayton Fabrication and Metal Works, Collins Music, Construction Trailer Specialists, Days Inn, DeWitt Company, Duckett Truck Center, Ferguson Medical Group, First Midwest Bank, Focus Bank, Garage Door Company of Sikeston, J. C. Penney, J-J-N Enterprises, Lowe's, Meyers Supply Company, Slusher Farm and Home Center, Mitchell Insurance, NewWave Communications, Pyramid Roofing Company, Retco Trailer Manufacturing, Steward Steel, The UPS Store, and Walgreens with multiple locations for Dollar General, Raymond James Financial, State Farm Insurance, and U. S. Bancorp.

On November 3, 1861, from Cairo, Illinois, Brigadier General Ulysses S. Grant wrote a letter to Colonel Richard J. Oglesby, commander of the Union Headquarters District Southeast Missouri at Bird ’ s Point, ordering his troops to " strike for Sikeston " from the Mississippi River town of Commerce.

* On April 1, 1965, Ronald Reagan was the guest speaker for the Sikeston Chamber of Commerce ’ s annual banquet and was presented an “ Honorary Cotton Picker of Southeast Missouri ” plaque, perhaps as part of an April Fools ' Day joke.

The Depot Museum exhibits the intriguing history of Sikeston and Southeast Missouri through permanent and rotating displays.

* Veterans ' Park-A park dedicated to the hundreds of men and women from Sikeston and other communities in Southeast Missouri who have valiantly served their country in times of war, the park features a large, lighted granite monument and American flag display.

* Southeast, based in Sikeston

It goes from Sikeston, Missouri, at Interstate 55 to Chicago, Illinois, at Interstate 94.

Between the junction of I-55 and I-57 in Sikeston, Missouri and the junction of I-55 and I-90 / 94 in Chicago, I-55 travels for, while the combination of I-57 and I-94 is only long between the same two points.

Likewise, at its southern end, Chicago is the control city listed for I-57 on signs on northbound I-55 south of Sikeston, Missouri, even though I-55 also goes to Chicago.

In the state of Missouri, Interstate 57 runs northbound from Sikeston to the Cairo I-57 Bridge over the Mississippi River south of Cairo, Illinois.

From the December 1, 1938 edition of the Sikeston ( Missouri ) Herald:

( Sikeston ( Missouri ) Herald, December 1, 1938 )

( Sikeston ( Missouri ) Herald, December 1, 1938 )

On June 20, 1905, The Chaffee Real Estate Company of St. Louis, Missouri purchased of land from a local farmer, John Witt of Sikeston, Missouri, for $ 140, 000.

In February of 2012, a 4. 0-magnitude earthquake struck the area, not far from Sikeston, Missouri and Cairo, Illinois ; the impact was felt across multiple states.

Sikeston () is a city located both in southern Scott County and northern New Madrid County, in the U. S. state of Missouri.

It is geographically situated just north of the " Missouri Bootheel ", although many locals consider Sikeston a part of it.

By way of Interstate 55, Interstate 57, and U. S. Route 60, Sikeston is close to the halfway point between St. Louis, Missouri and Memphis, Tennessee and 4 hours away from Nashville, Tennessee.

* During World War II until 1944, the Sikeston Memorial Municipal Airport which was previously dedicated on July 3 – 4, 1934, was known as Harvey Parks Airport and included long, barrack-style buildings as a site of the Missouri Institute of Aeronautics, which was established after General Hap Arnold asked flight training operations to triple their enrollments.

* Sikeston is also home to the Missouri National Guard unit Company C 1140th Engineer Battalion which took part in Operation Iraqi Freedom from February 2004 until February 2005.

* In 1942, the last lynching in Missouri took place in Sikeston.

* Sikeston Bulls-A minor league baseball team and part of the collegiate wood bat KIT League, which consists of teams from Missouri, Kentucky, Tennessee, and Illinois.

In addition, the Sikeston Missouri Arts Council and the Sikeston Art League offer a number of community concerts, cultural performances and art shows throughout the year.

Sikeston ended its season, losing in the state semifinals to Jefferson City Helias, one step short of the Class 4 State Championship game.

* Brandon Barnes, a former Washington Redskins NFL player, former all-conference linebacker at the University of Missouri, and former all-state defensive back for the 1998 conference champion Sikeston High School football team.

* Historic maps of Sikeston in the Sanborn Maps of Missouri Collection at the University of Missouri

Hulshof was born in Sikeston, Missouri, and attended the University of Missouri.

Sikeston, the largest city in the county and the fourth settlement to be founded, was settled in 1800 and was laid out in 1860 by John Sikes on the Cairo & Fulton Railroad.

* Sikeston Career & Technology Center-Sikeston-A technical school based out of the Sikeston R-VI School District.

Parkes, who now resides in Spain, was born in Sikeston in 1944 and grew up in Canalou.

* Scott Crockett, born in Sikeston, attended school in Gideon.

The Morehouse Elementary School is part of the Sikeston school system.

The Morehouse Elementary School was closed by the Sikeston School Board.

On the same day, a tornado also struck the nearby city of Sikeston.

As of the 2000 U. S. Census, the city had a population of 16, 651 ; a 2008 estimate showed the population to be 17, 096, an increase of 2. 67 %, and is the third largest city in Missouri's 8th Congressional District after Cape Girardeau and Sikeston.

It borders the city of Sikeston to the east.

Although popular family restaurant Lambert's Cafe is generally referred to as being located in Sikeston, the restaurant is actually located just inside the Miner city limits.

Lambert's originated in Sikeston, but moved closer to I-55, which is located on the eastern side of Miner.