When the plague hits, the deprivation of this symbol of freedom becomes more pronounced, as the beaches are closed, as is the port.

* 541-542: First pandemic of bubonic plague ( Plague of Justinian ) hits Constantinople and the rest of Byzantine Empire.

* A brief outbreak of plague hits Britain.

* Another plague hits Rome.

* An outbreak of a plague hits Athens and the disease ravages the densely packed city ( modern DNA analyses of material from ancient cemeteries suggest the mortal disease may have been typhus ).

* 1630, A black plague spread from Milan hits the city

During the autumn of 169 AD when Roman troops were returning to Aquileia, the great plague broke out and the emperor summoned Galen back to Rome.

It is most likely that this was the same plague that struck Rome during Marcus Aurelius ’ reign.

The jubilee of 1400 drew to Rome great crowds of pilgrims, particularly from France, in spite of a disastrous plague.

* Hostilian, Roman emperor ( of plague in Rome )

Pelagius fell victim to the plague that devastated Rome at the end of 590.

* Rome suffers from the plague.

The worship of Aesculapius is introduced from Epidaurus to Rome in the hope of averting the plague.

Together with King Ecgberht of Kent, he sent the priest Wighard to Rome, to be consecrated there after the death of Archbishop Deusdedit of Canterbury in 664, but Wighard died at Rome of the plague.

Gallus secured the throne after the death of emperor Decius at the hands of Cniva in the battle of Abrittus ( 251 ), and later had to manage an outbreak of plague that devastated Rome.

With the news of the death of the emperors, the army proclaimed Trebonianus Gallus emperor, but in Rome they were succeeded by Hostilian, who would die shortly afterwards in an outbreak of plague.

Rome was wracked with bouts of plague, and Saracens operating freely out of Sardinia ravaged the Tyrrhenian coasts.

In this period, from 211 to the accession of Diocletian and the establishment of the Tetrarchy in 286, Rome saw 28 emperors of whom only two had a natural death ( from the plague ).

One year later, Rome was struck by fire and a plague.

* 348 BC: A plague strikes Rome after a brief skirmish with the Gauls and Greeks.

* 293 BC: After yet another plague, the books were consulted, with the prescription being ' that Aesculapius must be brought to Rome from Epidaurus '; however, the Senate, being preoccupied with the Samnite wars, took no steps beyond performing one day of public prayers to Aesculapius.

In 1591, a plague broke out in Rome.

It was due to the efforts of the Brothers and alleged supernatural healings by de Lellis that the people of Rome credited De Lellis with ridding the city of a great plague and the subsequent famine.

He recounts the story of how a popular and well loved monk went to Rome and became " smitten by the plague and died ".

After succumbing to the plague in Rome, his body was brought back and passed through Ackworth at which point " nothing could satisfy the ignorant but faithful love of the old hearers " and the coffin was opened.

In 1481 it housed Pope Sixtus IV, who had fled from the plague in Rome ; the Sala Papalina in one of the corner towers commemorates the event.

But at Rome and Genoa they experienced all the vexations and torments that hunger, plague, and poverty bring with them, and were forced to accept baptism in order to escape starvation.

In that same year there was an epidemic of plague in Rome but Frascati was unaffected.

If a nation wished to get a head start in physical fitness over all other nations, it would start its kindergarten students on a program of gymnastics the day they entered and thus eliminate a large number of the problems that plague American schools.

However, years of activism, and fighting for the Republican side of the Spanish Civil War have left him disillusioned .</ br > When the plague epidemic is virtually over, Tarrou becomes one of its last victims, but puts up a heroic struggle before dying.

Ovid, on the other hand, supposes that the island was not uninhabited at the time of the birth of Aeacus, and states that, in the reign of Aeacus, Hera, jealous of Aegina, ravaged the island bearing the name of the latter by sending a plague or a fearful dragon into it, by which nearly all its inhabitants were carried off, and that Zeus restored the population by changing the ants into men.

Pseudolus, an excellent liar, uses Philia's cheery disposition to convince Lycus that she has picked up a plague from Crete, which causes its victims to smile endlessly in its terminal stages.

Due to the use of these biological weapons, and the apparent lack of medical advancement necessary to defend surrounding regions from them, widespread epidemics such as the bubonic plague quickly moved across all of Europe, destroying a large portion of its population.

On its return in 1603, for example, the plague killed 38, 000 Londoners.

There is some controversy over the identity of the disease, but in its virulent form, after the Great Plague of Marseille in 1720 – 1722, the Great Plague of 1738 ( which hit Eastern Europe ), and the Russian plague of 1770-1772, it seems to have gradually disappeared from Europe.

Plague is often synonymous with " bubonic plague " but this describes just one of its manifestations.

The account indicates that the Philistine city and its political territory were stricken with a " ravaging of mice " and a plague, bringing death to a large segment of the population.

This humiliating treaty, the contemporary spread of plague with its devastating effects and the chaotic situation in the East with the Sassanian invasions left Gallus with a very bad reputation amongst the latter Roman historians.

During its initial, and most deadly waves, approximately 200, 000 people were killed by the plague, and, by the 15th century, Cairo's population had been reduced to between 150, 000 and 300, 000.

After a ten-year residency in Edessa, in his sixties, Ephrem succumbed to the plague as he ministered to its victims.

Spread of the plague was slowed in surrounding areas, but the cost to the village was the death of around 75 % of its inhabitants.

After little more than a year ( when he would have studied the regular trivium of grammar, rhetoric and logic, rather than the later quadrivium of geometry, arithmetic, music and astronomy / astrology ), he was forced to leave Avignon when the university closed its doors in the face of an outbreak of the plague.

Baltic Old Prussian probably ceased to be spoken around the beginning of the 18th century due to many of its remaining speakers dying in the famines and bubonic plague epidemics harrowing the East Prussian countryside and towns from 1709 until 1711.

The plague ravaged the densely packed city, and in the long run, was a significant cause of its final defeat.

During this pandemic, the United States saw its first outbreak: the San Francisco plague of 1900 – 1904.

The Venice convention of 30 January 1892 was on cholera by the Suez Canal route ; that of Dresden of 15 April 1893, on cholera within European countries ; that of Paris of 3 April 1894, on cholera by the pilgrim traffic ; and that of Venice, on 19 March 1897, was in connection with the outbreak of plague in the East, and the conference met to settle on an international basis the steps to be taken to prevent, if possible, its spread into Europe.

Each government had to notify to other governments on the existence of plague within their several jurisdictions, and at the same time state the measures of prevention which are being carried out to prevent its diffusion.

As regards the precautions to be taken on land frontiers, it was decided that during the prevalence of plague every country had the inherent right to close its land frontiers against traffic.

It is believed by the faithful that on its way from the island the plague scratched one of the fortification stones of the old citadel to indicate its fury at being expelled ; St. Spyridon is also attributed the role of saving the island at the second great siege of Corfu of 1716.

Film critics noted that the British film 28 Days Later ( 2002 ) and its sequel 28 Weeks Later both feature a rabies-type plague ravaging Great Britain, analogous to I Am Legend.