In 1999 a further setback occurred when 18-year-old Jesse Gelsinger died in a gene therapy trial.

According to Bernard Lewis, " The Arab historians, if they mention this engagement Battle of Tours at all, present it as a minor skirmish ," and Gustave von Grunebaum writes: " This setback may have been important from the European point of view, but for Muslims at the time, who saw no master plan imperilled thereby, it had no further significance.

Unfortunately for Lean, the project suffered a further setback when Bolt suffered a massive stroke and was unable to continue writing ; the director felt that Bolt's involvement would be crucial to the film's success.

A further setback occurred in April 1658 when, in the midst of the Dano-Swedish war, Denmark ceded Bornholm to Sweden under the terms of the Treaty of Roskilde.

By 1845, the work was largely complete, though Madden was to suffer one more setback when a fire broke out in the Museum bindery, destroying completely some further works from the collection.

In August 1840 the New Zealand Company suffered a further setback when the Legislative Council in New South Wales decreed that payment for land in New Zealand must go directly to the original inhabitants, and that no individual sale could exceed " four square miles ".

A further ( and apparently unrelated ) setback occurred on July 4, when Gagné awoke with intense pain in his back.

This congestion is having a detrimental effect on the city, and residents have repeatedly called for a bypass to take this North / South road and its traffic away from the city, but the National Assembly for Wales rejected these calls in 2004, presenting a further setback for residents campaigning on the issue.

The elimination of Oster's group in April 1943 ( his deputy Hans von Dohnanyi and Lutheran theologian Dietrich Bonhoeffer were arrested, and Oster was placed under house arrest ) was a further setback that demoralized the conspirators and disrupted their efforts.

Talmadge had been increasingly bored with filmmaking before the talkie challenge came along, and this setback seems to have discouraged her from further attempts.

Dryburgh being one of many establishments who sought the generosity of the Galloway lords got a further setback in 1234 when Alan, the last of the line of Galloway lords, died.

After there was optimism he was close to returning to the lineup in December, he suffered a setback with his left knee and underwent further surgery in February 2012.

Whitbread was expected to return to training near the time of the international break in September, however a further setback kept him out until the new Year.

The afformentioned land development company received a further setback in 2006 when the then Minister for Transport wrote advising them that the airport was to be operated in its current location and in accordance with their lease from the Federal Government.

Port Essington suffered a further setback when the settlement was demolished by a cyclone on 25 November 1839.

Wonder's career suffered a setback when Tubby was killed in 1988, and he recorded for several other record producers at Sonic Sound, enjoying a further hit with the Lloyd Dennis-produced " It's Over Now ", leading to the release of his first album, No More Chance, although his success in this era was limited.

A second family setback scared him even further.

During his time in Merton he was appointed a Magistrate, and in 1770 the High Sheriff of Surrey but suffered a further setback in 1777 when Barbara died, leaving him a widower for the second time at the age of only 55.

They failed to secure a record deal in London, and suffered a further setback when guitarist Ronnie Matthews and drummer Marshall were jailed for a week after their Clapham squat was raided, and they returned to Belfast.

He received further setback in the 2006 – 07 season when he had stomach injuries which kept him sidelined for half a year.

The first wave of English-speaking settlers arrived in North America during the 17th century, followed by further migrations in the 18th and 19th centuries.

The large and diverse population of antibodies is generated by random combinations of a set of gene segments that encode different antigen binding sites ( or paratopes ), followed by random mutations in this area of the antibody gene, which create further diversity.

In Aristotle, substances are to be clarified by stating their definition: a note expressing a larger class ( the genus ) followed by further notes expressing specific differences ( differentiae ) within the class.

They are followed by a further wicked king, or " little horn ", who subdues three of the ten ( 7: 24 ), speaks against the Most High, wages war against the saints, and attempts to change the set times and laws ( 7: 25 ); after ' a time and times and half a time ', this king is judged and stripped of his kingdom by an " Ancient of Days " and his heavenly court ( 7: 26 ); next, " one like a son of man " approaches the Ancient of Days and is invested with worldwide dominion ; moreover, his everlasting reign over all kings and kingdoms is shared with " the people of the Most High " ( 7: 27 )

A further distinction is sometimes made in the ordering of the letters, to represent the order of the episodes, where the patient's normal state is euthymic, interrupted by episodes of mania followed by depression ( MD ) or vice versa ( DM ).

This WE. 177 laydown weapon supplemented the remaining modified Blue Steel missiles using a low-level penetration followed by a pop-up manoeuvre to release the weapon at Forty-eight live operational rounds were deployed on 48 Vulcan and Victor bombers plus a further five live rounds as operational spares.

The oldest Protestant groups separated from the Catholic Church in the 16th century Protestant Reformation, followed in many cases by further divisions.

However, further sieges followed in the course of attacks from the Arabs, a first from 674 to 678, and a second from 717 to 718.

As a result, these first releases were followed by further distributions across much of the region, although their effectiveness on other crops, such as cabbages, has been questioned ; when the toads were released at Wau, the cabbages provided insufficient shelter and the toads rapidly left the immediate area for the superior shelter offered by the forest.

After independence the first one was carried out in 1991, further rounds followed in 2001 and 2011.

On June 19, 1999, the first public beta of Counter-Strike was released, followed by numerous further " beta " releases.

Geographical numbers are often further expanded decimally to represent more specific areas, sometimes followed by a capital letter indicating a particular city.

" Poe followed with further Auguste Dupin tales: " The Mystery of Marie Rogêt " in 1843 and " The Purloined Letter " in 1845.

Although further persecutionary edicts followed, compelling the arrest of the Christian clergy and universal acts of sacrifice, the persecutionary edicts were ultimately unsuccessful ; most Christians escaped punishment, and pagans too were generally unsympathetic to the persecution.

The Strata Diocletiana, which ran from the Euphrates to Palmyra and northeast Arabia, is the classic Diocletianic frontier system, consisting of an outer road followed by tightly spaced forts followed by further fortifications in the rear.

A further improvement on the Nova design followed the next year, the SuperNOVA.

Severe fires can lead to significant further erosion if followed by heavy rainfall.

White's rework of the book was extremely well received, and further editions of the work followed in 1972, 1979, and 1999 ; an illustrated edition followed in 2005.

This was followed by further studies with Pierre François Wartel, Delle Sedie and Mathilde Marchesi in Paris.

When the church moved further North the Smith and Armstrong families followed it.

This is often followed by a connecting passage, or episode, developed from previously heard material ; further " entries " of the subject then are heard in related keys.

Addresses are assigned according to the street or avenue number, followed by a dash and the number of meters it is away from the intersection further simplifying address location.

In 1938, Edward Kasner's nine-year-old nephew, Milton Sirotta, coined the term googol which is, then proposed the further term googolplex to be " one, followed by writing zeroes until you get tired ".