Safety profiles of newer drugs are often not as well established as for those that have a long history of use.

Not long after, Bosschaert had married and established himself as a leading figure in the fashionable floral painting genre.

The other long established club in the city ' Os Galitos ' was founded in 1904 and water related sports such as swimming, sailing and rowing are some of its longest traditional strongest specialities, other sections in the club include chess, basketball, snooker, pool and billiards among others, but rowing is the modality in which the club has a maintained a long and proud tradition going back more than one hundred years, reaching the highest possible excellence as a club with several of its individual and team of rowers having represented Portugal Internationally and at the Olympic games with good classifications on more than a just few occasions.

The Therapeutae, pagan ascetic hermits and loosely organized cenobitic communities described by the Hellenized Jewish philosopher Philo of Alexandria in the first century, were long established in the harsh environments by Lake Mareotis close to Alexandria, and in other less-accessible regions.

It enlarged a network of monitoring sites to determine how acidic the precipitation actually was, and to determine long term trends, and established a network for dry deposition.

In addition to the towns and monuments noted below, the Black Forest is crossed by numerous long distance footpaths, including some of the first to be established.

Charles II of England was concerned by the unregulated copying of books and passed the Licensing of the Press Act 1662 by Act of Parliament, which established a register of licensed books and required a copy to be deposited with the Stationers ' Company, essentially continuing the licensing of material that had long been in effect.

Spiritual and philosophical institutions have been allowed to be established or re-established, as long they are not perceived to be a threat to the power of the CPC.

The actual origin of this anomaly is clearly established in a long line of disputes and temporary agreements which was finally concluded in 1804, when southern Southwick, ( whose residents sought to leave Massachusetts ), was split in half.

Much of the Mediterranean coastal terrain was suitable for mounted action and there was a long established culture of horsemanship amongst the Arab and Berber inhabitants.

Pope Cyril IV established very friendly relations with other denominations, to the extent that when the Greek Patriarch in Egypt had to absent himself for a long period of time outside the country, he left his Church under the guidance of the Coptic Patriarch.

But then it was already a long established practice that Rome itself was only a ceremonial capital, as the actual seat of the Imperial administration was determined by the needs of defense.

Dartford Priory was established long after the primary period of monastic foundation in England had ended.

The town is first mentioned in 742 under the name of " Erphesfurt ": in that year, Saint Boniface writes Pope Zachary to tell him that he had established three dioceses in Thuringia, one of which " in a place called Erphesfurt, which for a long time has been inhabited by pagan natives.

The constitutionality of our income tax system — including the role played within that system by the Internal Revenue Service and the Tax Court — has long been established.

Italian film production held up during the war, with long features already established as the main form.

The hunting of foxes with packs of hounds, long an established pursuit in Europe, especially the British Isles, was exported by European settlers to various parts of the New World.

He did not need to prove the common parentage of Sanskrit with Persian, Greek, Latin and German, for previous scholars had long established that ; but he aimed to trace the common origin of those languages ' grammatical forms, of their inflections from composition – a task which no predecessor had attempted.

Florida has grown as well, driven to a great extent by its long established tourism industry but also by its position as a gateway to the Caribbean and Latin America.

" This was not respected for long and Gibraltar has had for many years an established Jewish community, along with Muslims from North Africa.

Documentary and archeological evidence indicate that Arab or Indian traders introduced gunpowder, gonnes, muskets, blunderbusses, and cannon to the Javanese, Acehnese, and Batak via long established commercial trade routes around the early to mid 14th century CE.

In some jurisdictions, when an unmarried man and women live together long enough, there are deemed to have established a common-law marriage.

The separation of charge establishes an electric field that opposes the migration of further charge, so a steady electrical potential is established for as long as the charge is flowing.

Many pubs use the name " inn ", either because they are long established and may have been formerly coaching inns, or to summon up a particular kind of image.

The wear and tear of life have taught me that very few friends of mutual friends long to see foreign strangers, but I planned on being the soul of tact, of giving them plenty of outs was there the tiniest implication that their cups were already running over without us.

But one cannot escape the suspicion that all this non-stop harping on the misdeeds of the long liquidated `` anti-party '' group would be totally unnecessary if there were not, inside the party, some secret but genuine opposition to Khrushchev on vital doctrinal grounds, on the actual methods to be employed in the `` transition to communism '' and, last but not least, on foreign policy.

All week long the President clearly was playing a larger personal role in foreign affairs ; ;

Rome, for so long victorious against its enemies, was now at the mercy of its foreign conquerors.

The Brazilian foreign policy under the Lula da Silva administration had been focused on the following directives: to contribute toward the search for greater equilibrium and attenuate unilateralism ; to strengthen bilateral and multilateral relations in order to increase the country's weight in political and economic negotiations on an international level ; to deepen relations so as to benefit from greater economical, financial, technological and cultural interchange ; to avoid agreements that could jeopardize development in the long term.

He had not resided there long when an edict appeared ( August 8, 1564 ) banishing all foreign dissidents.

Thanks to the consistent position of Austria during the meeting of EU foreign ministers, a long period of instability and the questioning of the determination of the Croatian government to surrender war criminals has ended successfully.

Meanwhile, a human spaceship that was sent out to space long ago when the planetary winter began crashes in some foreign planet and the local civilization buries all evidence of the accident.

After the revolution Egypt ’ s foreign exchange reserves fell from $ 36 billion in December 2010 to only $ 16. 3 billion in January 2012, also in February 2012 Standard & Poor ’ s rating agency lowered the Egypt ’ s credit rating from B + to B in the long term.

The 14th century saw the start of what would prove to be a long era of foreign encroachment in the Faroese economy.

The political states of Iraq and Syria were formed by the United Kingdom and France following the defeat of the Ottoman Empire in World War I. Iraq and Syria are united by historical, social, political, cultural and economic relations, but share a long foreign drawn border.

Monroe had long been concerned about foreign influence on the presidency.

A long bill was introduced, with 150 headings, in which were stated the grievances caused by the aggressions of the Curia ; all reservations and commissions were to be done away, the exportation of money was forbidden, and the foreign collectors were to be removed.

Moi's government in 1993 agreed to economic reforms long urged by the World Bank and the International Monetary Fund, which restored enough aid for Kenya to service its $ 7. 5 billion foreign debt.

According to Serge Klarsfeld, since the now complete and constant publicity which the artworks got in 1996, the majority of the French Jewish community is nevertheless in favour of the return to the normal French civil rule of prescription acquisitive of any unclaimed good after another long period of time and consequently to their ultimate integration into the common French heritage instead of their transfer to foreign institutions like during World War II.

The Moldovan government does not maintain many formal barriers to foreign investment, and the Moldovan embassy reports that foreign investors are free to " place their investments throughout the Republic of Moldova, in any area of business activity, as long as it does not go against the interests of the national security, anti-monopoly legislation, environment protection norms, public health and public order.

Not only his social and economic views guided the country's socio-economic course for a long time, his use of the imagery, ' a yam between two boulders ' in Nepal's geopolitical context, formed the principal guideline of the country's foreign policy for future centuries.

Traffic in benefices, the sale of dispensations, and the like, did not cover the loss of local sources of revenue in the long absence of the papacy from Rome, foreign revenue diminished by the schism, expenses for the pacification and fortification of Rome, the constant wars made necessary by French ambition and the piecemeal reconquest of the Papal States.

In 1891, after a long spell in foreign waters, he applied for the two-year torpedo training course on, an important career step.

In 1811, prompted by discussions with a Chinese student about Chinese script, Silvestre de Sacy considered a suggestion made by Georg Zoëga in 1797 that the foreign names in Egyptian hieroglyphic inscriptions might be written phonetically ; he also recalled that as long ago as 1761, Jean-Jacques Barthélemy had suggested that the characters enclosed in cartouches in hieroglyphic inscriptions were proper names.

New generations of potential viewers were not raised watching soap operas with their mothers, leaving the long and complex story lines foreign to younger audiences.

The political states of Iraq and Syria were formed by the United Kingdom and France following the defeat of the Ottoman Empire in World War I. Iraq and Syria are united by historical, social, political, cultural and economic relations, but share a long foreign drawn border.

The Civil Rights Act of 1866 had already granted U. S. citizenship to all persons born in the United States, as long as those persons were not subject to a foreign power ; the framers of the Fourteenth Amendment added this principle into the Constitution to prevent the Supreme Court from ruling the Civil Rights Act of 1866 to be unconstitutional for lack of congressional authority to enact such a law and to prevent a future Congress from altering it by a mere majority vote.

:“ This gentleman has for several years stood at the head of our commercial community and he carries with him the esteem and kind wishes of the whole foreign society, honourably acquired by a long career of private charity and public spirit .”