The major drawback to this is the wide variation in quality of users ' audio cards.

A major drawback of current gesture interaction solutions is the lack of support for two necessary user interface design principles, feedback and visibility ( or affordance ).

A major drawback is that unlike OxyContin ( oxycodone continuous release ), methadone is not technologically engineered for sustained release of the drug so blood concentrations will fluctuate greatly between dosing.

One major drawback of this technique is wafer damage.

Being plugged into the wall is obviously a major drawback, but had one advantage: the timebase for the clock was driven off of a rectified version of 60 cycle AC current.

The major drawback of these drugs is that they have properties that can lead to many side-effects ; for example, amitriptyline and doxepin both have antihistaminergic, anticholinergic, and antiadrenergic properties, which contribute to their side-effect profile, while mirtazapines side-effects are primarily antihistaminergic, and trazadones side-effects are primarily antiadrenergic.

A major drawback of the Computing Surface architecture was poor I / O bandwidth for general data shuffling.

The other major drawback of MRP is that takes no account of capacity in its calculations.

The major drawback of this is that new gaps can be introduced or old gaps can be lost due to external influences.

A major practical drawback to this band is that because of the length of the waves, full size resonant antennas ( half wave dipole or quarter wave monopole antennas ) cannot be built because of their physical height.

The major drawback, apart from the short duration of a 16 mm film magazine, was that a large opaque frame had to be placed in front of the TV set in order to block out any stray reflections, making it impossible to watch the set normally while filming.

The major drawback is that the stands are necessarily set back a good distance from the pitch, especially at the ends of the pitch.

However, its major drawback is that detailed structural knowledge of a protein is often unavailable, and even when it is available, it can be extremely difficult to predict the effects of various mutations.

This is a potential problem — not a major drawback.

Another major drawback is that performance is relatively low when compared to other virtual file systems.

Some developers view this as a major drawback of this technique.

The major drawback to the E55 is the cooling system ( mainly the stock Bosch intercooler pump does not have sufficient flow rate ) which is highly prone to heat soaking after a series of high speed pulls.

The major drawback is the uncertainty of work and thus income, and in lack of company benefits such as a pension, health insurance in nations without socialized medicine, paid holidays and bonuses.

Prataprao Gujar's major drawback was his impulsive emotional nature.

One major drawback within the initial version of H. 323 was the lengthy, four-way H. 245 protocol handshake required during the opening up the logical channels of a telephony session.

The major drawback of germanium detectors is that they must be cooled to liquid nitrogen temperatures to produce spectroscopic data.

A major drawback is that the exponential horn allows for a narrowing of the radiation pattern as frequency increases, making for high frequency ' beaming ' on axis and dull sound off axis.

* The major drawback to this technique is that the cost of producing such a large number of sterile insects is often prohibitive in poorer countries.

The major drawback of solid-anode microfocus X-ray tubes is the very low power they operate at.

In 2008, effective January 1, 2009, the ADAAA broadened the interpretations and added to the ADA examples of " major life activities " including, but not limited to, " caring for oneself, performing manual tasks, seeing, hearing, eating, sleeping, walking, standing, lifting, bending, speaking, breathing, learning, reading, concentrating, thinking, communicating, and working " as well as the operation of several specified " major bodily functions ".

The second Abbasid caliph, Al Mansur ( 754 – 775 ) founded the city of Baghdad to act as a centre of learning, and included in its design a library-translation centre known as Bayt al-Hikma ‘ Storehouse of Wisdom ’, which continued to receive development from his heirs and was to provide a major impetus for Arabic-Persian translations of Hellenistic astrological texts.

Through the reputation of its venerable founder and its position as a major European centre of learning, Columba's Iona became a place of pilgrimage.

His last major publication before his death in 1995 was about learning.

* Axis I: Clinical disorders, including major mental disorders, learning disorders and substance use disorders

Local empire-builders such as the Ghaznavids, Ghurids and Timurids made Afghanistan a major medieval power as well as a learning center that produced the likes of Avicenna, Al-Biruni, and Rumi, among many other academic or iconic figures.

English as an international language ( EIL ) is EAL with emphasis on learning different major dialect forms ; in particular, it aims to equip students with the linguistic tools to communicate internationally.

In the context of e-learning, a major discussion in instructional theory is the potential of learning objects to structure and deliver content.

At one time, Leipzig was one of the major European centres of learning and culture in fields such as music and publishing.

The major difference between gestaltists and behaviorists is the focus of control over the learning activity: the individual learner is more key to gestaltists than the environment that behaviorists emphasize.

* Theory Into Practice ( TIP ) database brief summaries of 50 major theories of learning and instruction

Major universities include Cairo University ( 100, 000 students ), Alexandria University, and the 1, 000-year-old Al-Azhar University, one of the world's major centers of Islamic learning.

His son Idris II erected a splendid new capital at Fes and launched Morocco as a centre of learning and a major power.

There are four major issues to consider in supervised learning:

There are three major learning paradigms, each corresponding to a particular abstract learning task.

He left Seichō-ji shortly thereafter to study in Kamakura and several years later traveled to western Japan for more in-depth study in the Kyoto – Nara area, where Japan's major centers of Buddhist learning were located.

Hyperactivity, EEG abnormalities and seizures, and severe learning disabilities are major clinical problems later in life.

The major theories include dispositional ( trait ) perspective, psychodynamic, humanistic, biological, behaviorist and social learning perspective.

A major question of debate is the question of whether human psychological faculties are mostly universal and innate or whether they are mostly a result of learning, and hence subject to cultural and social processes that vary between places and times.

The Al-Azhar University in Cairo, Egypt, is a major centre of Sunni Islamic learning in the world.

He visit the major seats of Buddhist learning ( Udyana, Peshawar, and Taxila ).

:"... 27 January 2005, the sixtieth anniversary of the liberation of Nazi Germany's death camp at Auschwitz-Birkenau, where a combined total of up to 1. 5 million Jews, Roma, Poles, Russians and prisoners of various other nationalities, and homosexuals, were murdered, is not only a major occasion for European citizens to remember and condemn the enormous horror and tragedy of the Holocaust, but also for addressing the disturbing rise in anti-Semitism, and especially anti-Semitic incidents, in Europe, and for learning anew the wider lessons about the dangers of victimising people on the basis of race, ethnic origin, religion, social classification, politics or sexual orientation ...."

Dopamine plays a major role in the brain system that is responsible for reward-driven learning.