The major drawback to this is the wide variation in quality of users ' audio cards.

A major drawback of current gesture interaction solutions is the lack of support for two necessary user interface design principles, feedback and visibility ( or affordance ).

A major drawback is that unlike OxyContin ( oxycodone continuous release ), methadone is not technologically engineered for sustained release of the drug so blood concentrations will fluctuate greatly between dosing.

One major drawback of this technique is wafer damage.

Being plugged into the wall is obviously a major drawback, but had one advantage: the timebase for the clock was driven off of a rectified version of 60 cycle AC current.

The major drawback of these drugs is that they have properties that can lead to many side-effects ; for example, amitriptyline and doxepin both have antihistaminergic, anticholinergic, and antiadrenergic properties, which contribute to their side-effect profile, while mirtazapines side-effects are primarily antihistaminergic, and trazadones side-effects are primarily antiadrenergic.

A major drawback to learning Wubi is its learning curve.

A major drawback of the Computing Surface architecture was poor I / O bandwidth for general data shuffling.

The other major drawback of MRP is that takes no account of capacity in its calculations.

The major drawback of this is that new gaps can be introduced or old gaps can be lost due to external influences.

A major practical drawback to this band is that because of the length of the waves, full size resonant antennas ( half wave dipole or quarter wave monopole antennas ) cannot be built because of their physical height.

The major drawback is that the stands are necessarily set back a good distance from the pitch, especially at the ends of the pitch.

However, its major drawback is that detailed structural knowledge of a protein is often unavailable, and even when it is available, it can be extremely difficult to predict the effects of various mutations.

This is a potential problem — not a major drawback.

Another major drawback is that performance is relatively low when compared to other virtual file systems.

Some developers view this as a major drawback of this technique.

The major drawback to the E55 is the cooling system ( mainly the stock Bosch intercooler pump does not have sufficient flow rate ) which is highly prone to heat soaking after a series of high speed pulls.

The major drawback is the uncertainty of work and thus income, and in lack of company benefits such as a pension, health insurance in nations without socialized medicine, paid holidays and bonuses.

Prataprao Gujar's major drawback was his impulsive emotional nature.

One major drawback within the initial version of H. 323 was the lengthy, four-way H. 245 protocol handshake required during the opening up the logical channels of a telephony session.

The major drawback of germanium detectors is that they must be cooled to liquid nitrogen temperatures to produce spectroscopic data.

A major drawback is that the exponential horn allows for a narrowing of the radiation pattern as frequency increases, making for high frequency ' beaming ' on axis and dull sound off axis.

* The major drawback to this technique is that the cost of producing such a large number of sterile insects is often prohibitive in poorer countries.

The major drawback of solid-anode microfocus X-ray tubes is the very low power they operate at.

In a study of the use of econometrics in major economics journals, McCloskey concluded that economists report p values ( following the Fisherian tradition of tests of significance of point null-hypotheses ), neglecting concerns of type II errors ; economists fail to report estimates of the size of effects ( apart from statistical significance ) and to discuss their economic importance.

Despite his own great reputation as a military administrator, Hadrian's reign was marked by a general lack of major military conflicts, apart from the Second Roman-Jewish War.

* 1995 – 51 Pegasi is discovered to be the first major star apart from the Sun to have a planet ( and extrasolar planet ) orbiting around it.

People tend to drift apart, there are internal conflicts, egos going wild, and bad management was probably the major factor that contributed to the Stems breakup.

During the 1990s, several major corporations entered the Tri-Cities, which helped to begin diversifying the economy apart from the Hanford sector.

The major African American bands of the 1930s included, apart from the bands led by Ellington, Hines and Calloway, were those of Count Basie, Jimmie Lunceford, and Chick Webb.

In recorded history, major eruptions have been about 50 years apart, in 1895, 1945 and 1995 – 1996.

All the variations are in G major, apart from variations 15, 21, and 25, which are in G minor.

After he assumed the crown of Navarre in October 1349, Charles II visited his kingdom to be anointed in summer 1350 but otherwise apart from short visits spent the first 12 years of his reign almost entirely in France ; he regarded Navarre principally as a source of manpower with which to advance his designs to become a major power in France.

Nevertheless the damage incurred — including the death of Admiral Edward Montagu, 1st Earl of Sandwich — was so extensive that the Allies would be prevented from executing major naval actions for the rest of the season, apart from a failed attempt to intercept the Dutch East India Company ( VOC ) Return Fleet from the Dutch East Indies.

The major landmark in Folkestone, apart from the Harbour, is the Leas, the cliffs above the beach.

Most major streets adhere to a north-south / east-west orientation, forming a grid of major streets spaced one mile ( 1. 6 km ) apart from each other.

These forts were built at regular intervals, roughly ten to fifteen miles ( 24 km ) apart, and in any major gaps along the mountains.

Diaz's army suffered several major defeats, and his administration started to fall apart ..

It underwent major refurbishment in the mid 1990s, but the main part of the house is unchanged apart from the two chimney pots being reversed at some point in its history according to a local painting in the Bay Horse Inn at Kirk Deighton.

Furthermore, to increase the isolation, the area had no canals and had few roads, apart from a few turnpike roads, including the major ones from Leeds to Huddersfield and Bradford to Halifax.

The filibuster is a powerful parliamentary device in the United States Senate, which in recent years has meant that most major legislation ( apart from budgets and confirmations ) requires a 60 % majority to head off a filibuster.

The fugue of Variation 32 is set apart by its foreign key, E-flat major.

The Netherlands later joined France, and the British were outnumbered on land and sea in a world war, as they had no major allies apart from Indian tribes.

The Sauerland is a rural, hilly area spreading across most of the south-eastern part of North Rhine-Westphalia, in parts heavily forested and, apart from the major valleys, sparsely inhabited.

In each passage a different interval separates the pair — bassoons are a minor sixth apart, oboes are in minor thirds, clarinets in minor sevenths, flutes in fifths and muted trumpets in major seconds.

The first three notes of ( any ) major scale – fa, sol, la – are each a tone apart.

The 19th and 20th centuries saw few major changes, apart from the introduction of plane trees into the Walks.